Search Results within category "Women's Health"
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The Sexual Relationships Study
The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following:
Aim 1. Examine the heterogeneity in relationship quality among female college students.
Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence?
Aim 2. Examine the association between relationship characteristics and latent class membership.
Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality?
Aim 3. Examine the association between latent classes of relationship quality and condom use.
Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex?
Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Jessica Salas-Brooks at jis5940@psu.edu or 704-249-4252
Female
18 year(s) or older
N/A
Women's Health
Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis
Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women.
Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
N/A
Heart & Vascular, Pregnancy & Infertility, Women's Health
Site For COMET-PCOS
Site For COMET-PCOS
Patsy Rawa at prawa@pennstatehealth.psu.edu or 717-531-3692
Female
18 year(s) or older
NCT03229057
Women's Health
Efficacy of Virtual Reality Exposure Therapy Scripts for Social Phobia
This research is conducted to test if virtual reality technology is effective to help people face their social fears and promote the use of adaptive social skills in various settings. You will be immersed in a range of virtual reality environments and work with a research therapist to learn certain skills, such as managing fears of negative evaluation during job interviews, and interacting with peers in common social settings (e.g., classrooms, cafeterias).
Hani Zainal at nvz5057@psu.edu or 814-863-0115
All
18 year(s) or older
N/A
Men's Health, Mental & Behavioral Health, Women's Health
Understanding the Relationship between Education and Well-being among College Students with Disabilities
The purpose of the study is to gain an understanding of students’ experiences in college and their engagement help-seeking and healthy behaviors. Participation in the study involves completing a brief online-survey on Qualtrics, which we anticipate will take approximately 20 minutes to complete.
Amber O'Shea at amo5208@psu.edu or 814-867-5721
All
18 year(s) or older
N/A
Education, Mental & Behavioral Health, Women's Health
Coparenting, Infant Sleep, and Infant Development: An Intervention Study
This application proposes a randomized clinical trial (RCT) to evaluate the effects of a sleep-enhanced adaptation of an evidence-based transition-to-parenting coparenting intervention program [Family Foundations - FF). The study has three arms. In one arm, families will experience FF as originally formulated; in the second, families will receive an adapted FF that emphasizes coparenting in infant sleep contexts; the third arm will serve as controls. Assessments of coparenting and parenting in infant sleep contexts, parental adjustment to infant sleep behavior, choices about sleep arrangements, infant and parent sleep quality, and infant socio-emotional functioning, will serve as outcomes.
Morgan Loeffler at FF@psu.edu or 717-695-7050
All
18 year(s) or older
NCT03187561
Pregnancy & Infertility, Sleep Management, Women's Health
The Daily Reflections Study
This 14-day daily diary study is being conducted to better understand how young adults' thoughts and feelings about their bodies influence their health behaviors, and how their daily experiences and characteristics contribute to their health behaviors. Participants will be asked to complete a 10-20 minute baseline survey and a brief (5-8 minutes) daily survey each day for 14 consecutive days. Surveys will include questions about participants' mental and physical health, emotions, relationships, health behaviors, thoughts, and experiences.
Anna Hochgraf at akh7@psu.edu
All
18 year(s) or older
N/A
Smoking, Vaping, Nicotine and Tobacco, Mental & Behavioral Health, Women's Health
Behavior, Voice, and Sex Hormones Study
Hormones are molecules that deliver signals throughout the body. They influence behavior, sleep, hunger, stress, and virtually all other aspects of life. This study seeks to better understand several of these functions, specifically how hormones affect specific aspects of human behavior and psychology, as well as speech production. Following an initial lab visit, subjects will participate in the remainder of the study (~5 weeks) at home via the internet. On a daily basis, they will collect urine samples for hormone analysis, saliva samples for analysis of oral micro-organisms, and will submit voice samples for analysis of speech (e.g. measuring voice pitch and loudness). They will then complete an online survey designed to collect information about their behavior, and attitudes over the previous 24 hours. Subjects receive compensation for their participation.
Kevin Rosenfield at kar61@psu.edu
Female
18 year(s) or older
N/A
Language & Linguistics, Diabetes & Hormones, Women's Health
AWS-PSU: Active Women's Study at Penn State University
AWS-PSU: Active Women's Study at Penn State University
This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
N/A
Food & Nutrition, Muscle & Bone, Women's Health
Inositol Supplementation to Treat Polycystic Ovary Syndrome: A Double Blind Dose Ranging RCT (INSUPP-PCOS)
Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women in the U.S. and is characterized by both reproductive (anovulation and androgen excess) and metabolic dysfunction (insulin resistance). PCOS lacks a simple, safe and effective treatment for women of all ages and all weights. Recently
a dietary supplement, inositol, has been used widely to treat women with PCOS. However there are no well designed trials to address the risk/benefit ratio and identify the mechanism of action. In this study we propose a 3 month double blind (of both patients and investigators) randomized controlled trial of inositol supplementation compared to placebo. We hypothesis that women with PCOS who receive inositol supplementation will have a significantly greater reduction in serum total testosterone than women on placebo as well has improvement in glucose tolerance and decrease in fasting insulin.
Amyee McMonagle at amcmonagle@pennstatehealth.psu.edu
Female
18 year(s) or older
N/A
Women's Health
Management Of Pain After Cesarean Trial
This is a double blinded, placebo-controlled randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen and placebo on the patient's reported pain score on the second post-operative day after Cesarean delivery. We will also record opiate consumption and pain scores throughout the hospitalization of participants, and will survey patients at one and two weeks after surgery regarding opiate consumption and quality of life.
Avi Hameroff at ahameroff@pennstatehealth.psu.edu or 717-531-8142, ext=5
Female
All
NCT03929640
Pregnancy & Infertility, Women's Health
Functional and Mechanical Changes Following Total Ankle Arthroplasty
Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle.
The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
N/A
Men's Health, Muscle & Bone, Women's Health
Site for Strong Foundations: Intervening to Promote Co-Parenting in Expectant Parents and Healthy Child Development.
Our goal is to examine the efficacy of Strong Family Foundations parenting classes in reducing couple conflict, promoting co-parenting quality, parental sensitivity, and child development outcomes within families. We hope to enroll 220 couples in our parenting program. Participants will participate in parenting classes before and after the birth of their child, and research assessments 6 and 12 months postpartum.
Jenna Sassaman at jnk5173@psu.edu or 814-865-6902
All
18 year(s) or older
N/A
Children's Health, Pregnancy & Infertility, Women's Health
Precision AIM: Adaptive Text Message Intervention
This research is being done to determine if receiving interventional text messages can encourage physical activity levels. The type of message to be sent, along with the timing of the messages and consideration of weather will be explored for each person. The “mathematical formula” for each participant will be modified on a monthly basis throughout the six-month study to give participants the right message at the right time and weather conditions to encourage increased physical activity levels.
Deborah Reese at dlb43@psu.edu or 814-865-7935
All
18 year(s) or older
N/A
Men's Health, Mental & Behavioral Health, Women's Health
Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women
This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
NCT02822378
Food & Nutrition, Muscle & Bone, Women's Health
Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes
The goal of this study is to learn more about how people who smoke
cigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 814-867-2333
All
18 year(s) or older
N/A
Men's Health, Addiction & Substance Abuse, Women's Health
Exploring Facilitators and Barriers to Self-Initiated Sexually Transmitted Infection Testing among College Student
The purpose of this study is to identify modifiable facilitators and barriers to self-initiated sexually transmitted infection (STI) testing among college students aged 18 – 24 years. This study will entail filling out a demographic and sexual history questionnaire, and a private face-to-face interview.
Oluwamuyiwa Adebayo at DAresearch@psu.edu or 814-867-4656
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Men's Health, Women's Health
Examining Maternal Reward Responsiveness and the Intergenerational Risk for Depression
Children of depressed mothers are at high risk for developing depression, particularly as youth age into adolescence, yet relatively little is known about the mechanism underlying risk for depression in youth with depressed mothers. The present study examines maternal reward responsiveness, measured across neurophysiological, behavioral, and self-report measures as a marker of depression in mothers of adolescents. Associations between maternal reward responsiveness and parenting difficulties often associated with maternal depression, as well as adolescent functioning will be examined, to explore the clinical impact of maternal reward responsiveness on the intergenerational transmission of depression.
Sarah Shahriar at sshahriar1@pennstatehealth.psu.edu or 717-531-0003, ext=285189
All
All
N/A
Children's Health, Mental & Behavioral Health, Women's Health
Postmenopausal women and their endothelium: Is acute dietary nitrate supplementation protective?
Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development.
The purpose of this study is to test the effects of a one time dose of beetroot juice on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice and blood pressure and blood vessel function will be measured.
Jocelyn Delgado at jmd956@psu.edu or 408-679-8390
Female
18 year(s) or older
NCT03644472
Food & Nutrition, Heart & Vascular, Women's Health
A randomized, double-blind, placebo-controlled, phase 2 trial assessing the efficacy, safety and dose-response of quinagolide extended-release vaginal rings administered sequentially for 4 menstrual cycles in women with moderate to severe endometriosis-related pain
This study is looking to see if a new self-insertable vaginal ring has potential to replace oral hormone suppressing pills for treating endometriosis pain.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
NCT03692403
Women's Health
Centre County COVID-19 Data 4 Action Study
The purpose of this research is to evaluate the extent of COVID-19 risk and perceived risk among Centre County residents and students, and how those risks evolve from the time isolation guidelines were implemented through a return to normal functioning.
Participants in this research will complete an electronic survey with questions about their demographic, about their exposure to COVID-19, and about how COVID-19 has affected their health and work/education.
Data from this research will be used to inform Centre County planning authorities and the Pennsylvania State University about the needs of communities, including needs for information dissemination and for potentially actionable, local interventions in response to the COVID-19 pandemic.
Susan McHale at src-ssri@psu.edu
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Men's Health, Women's Health
Using Social Media to Perform Parasocial Relationships with Celebrities
This research is being conducted to create a better understanding of how parasocial relationships are developed by young adults with actors, artists/musicians, and fictional characters. This research aims to understand the extent of how Tumblr users interact and follow celebrities or fictional characters and the attachment they form to them. The participants will fill out an online survey asking questions about their emotional intensity and dedication to a celebrity or fictional character as well as whether you share about them and what technology they use. Participants may skip any questions that she/he would prefer not to answer.
Courtney Smith at ces92@psu.edu
All
18 year(s) or older
N/A
Men's Health, Education, Women's Health
A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain
We are looking to conduct a study looking at the effects of cannabidiol (CBD) in patients with endometriosis. We believe that CBD will improve both pain and quality of life.
The study will last a total of 12 weeks and involve several onsite visits in addition to daily pain assessments.
Amanda Chu at achu@pennstatehealth.psu.edu
Female
18 year(s) or older
NCT04527003
Pain Management, Women's Health
Site for EMPOWER: Endometriosis diagnosis using MicroRNA: PrOspective study in Women to allow Early disease Recognition
This is a multi-center, observational study, the results of which will be used to support marketing for the intended use of the DotEndo investigational diagnostic. DotEndo is a non-invasive in vitro diagnostic test that measures levels of circulating miRNA biomarkers in whole blood. The DotEndo blood test will use a distinct classifier algorithm, based on levels of disease-specific miRNAs, to aid in the diagnosis of active endometriosis disease.
The study will enroll women 18 to 49 years old who have been referred to surgery for suspected endometriosis and other benign gynecological indications. Subjects will answer questionnaires and whole blood and saliva samples will be collected prior to and after surgery. Participation is expected to be approximately 3 months with some subjects continuing with annual follow-up post-surgery for 2 years.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
NCT04598698
Women's Health
Voice Perception Study
This is a voice perception study that asks participants to listen to voices and rate on various attributes such as attractiveness, social status, health, and others.
Toe Aung at txa96@psu.edu or 775-225-1747
All
18 year(s) or older
N/A
Men's Health, Women's Health
Site for Tomosynthesis Mammographic Imaging Screening Trial (TMIST)_EA1151_PSCI 19-080
This study is being done to answer the following question:
Can tomosynthesis mammography, three-dimensional x-ray imaging of the breast, lower your chance of developing life-threatening breast cancer through routine screening compared with digital mammography, two-dimensional x-ray imaging of the breast?
We are doing this study because we want to find out which of the two usual approaches to breast cancer screening are better in the early detection of life-threatening breast cancers.
Swati Shah at sshah@pennstatehealth.psu.edu
Female
18 year(s) or older
NCT03233191
Prevention, Cancer, Women's Health
Respect and Satisfaction in Same-Sex Romantic Relationships
The purpose of this study is to expand on previous research looking at respect and relationship satisfaction among heterosexual relationships and compare it to that of same-sex relationships to find where they are similar or different. Participants will complete self-report measures regarding their romantic relationships, including respect toward partner, satisfaction, and attitudes toward love. 30 minutes will be required for the study.
Michelle Yarwood at mxg925@psu.edu or 814-867-4851
All
18 year(s) or older
N/A
Men's Health, Mental & Behavioral Health, Women's Health
COVID-19 in Pregnancy Study
We are interested in learning more about how COVID-19 impacts the health of moms and their babies from pregnancy to the first month of life. This study will help us gather more evidence that could guide the clinical care provided to moms and their babies.
Kristin Sznajder at ksznajder@phs.psu.edu
Female
18 year(s) or older
N/A
Children's Health, Pregnancy & Infertility, Women's Health
Site For ENDOmarker
Site For ENDOmarker
Patsy Rawa at prawa@pennstatehealth.psu.edu or 717-531-3692
Female
18 year(s) or older
NCT03161704
Women's Health
A randomized double-blind placebo controlled trial to assess the effectiveness of low-dose naltrexone in combination with standard treatment in women with chronic pelvic pain secondary to endometriosis.
Pelvic pain associated with endometriosis is in part due to inflammation of a layer of tissue in the abdomen (stomach area). This leads to the great potential of relieving endometriosis related pelvic pain in a non-narcotic medication by decreasing the inflammation. The purpose of this study is to evaluate how a low dose of naltrexone compared to placebo (inactive substance) impacts your daily pain and the quality of your life with endometriosis. Naltrexone is approved by the U.S. Food and Drug Adminstration (FDA) for the treatment of opioid overdose and addiction. At much lower doses, naltrexone has been shown to be beneficial in pain relief of inflammatory disorders with promising results, but the use of the low dose in this study to treat endometriosis pain is investigational and has not been approved by the FDA.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
NCT03970330
Pain Management, Women's Health