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Suggestions within category "Women's Health"


38 Study Matches

The Sexual Relationships Study

The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following: Aim 1. Examine the heterogeneity in relationship quality among female college students. Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence? Aim 2. Examine the association between relationship characteristics and latent class membership. Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality? Aim 3. Examine the association between latent classes of relationship quality and condom use. Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex? Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Jessica Salas-Brooks at jis5940@psu.edu or 704-249-4252
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Be enrolled at Pennsylvania State University (University Park Campus)
Be between the ages of 18-22 years
Be a female college student
Be sexually active with male partners in the previous 3 months
Exclusion Criteria:
Are not enrolled at Pennsylvania State University (University Park Campus)
Are under the age of 18 or over the age of 22.
Are not a female college student
Are not sexually active with male partners in the previous 3 months
Women's Health
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

This study is for patients who have been diagnosed with moderate to severe ulcerative colitis (UC) who are experiencing bloody diarrhea, abdominal pain, and a sudden and constant feeling of needing to move their bowels. Additionally, patients have been unable to tolerate or have had an insufficient response to treatment with medications that help reduce inflammation associated with UC. This research is being done to evaluate the safety of different doses of ABT-494 (study medication) and determine how well it works, as well as how the study medication is absorbed, distributed and eliminated in the body over time.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02819635
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Inclusion Criteria:
Diagnosis of ulcerative colitis for at least 90 days
Demonstrated an inadequate response to, loss of response to, or intolerance to steroids, immunosuppressants and/or biologic therapies
Exclusion Criteria:
Have a current diagnosis of Crohn's disease, fulminant colitis and/or toxic megacolon
History of total colectomy or ileostomy
Taking a probiotic and has not been on a stable dose for at least 10 days
Men's Health, Digestive Systems & Liver Disease, Women's Health
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Location
State College, PA

Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis

Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women. Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Women, Ages 18-45
Do or do not have endometriosis
Have normal blood pressure
Exclusion Criteria:
Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
High Blood Pressure
Abnormal liver function
Known allergy statins (Lipitor)
Pregnant or Breastfeeding
Heart & Vascular, Pregnancy & Infertility, Women's Health
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Location
State College, PA

Site For COMET-PCOS

Site For COMET-PCOS
Patsy Rawa at prawa@pennstatehealth.psu.edu or 717-531-3692
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03229057
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Inclusion Criteria:
Polycystic ovary syndrome (PCOS)
BMI >=25 to <=45
In good general health
Willing to avoid pregnancy for duration of study
Exclusion Criteria:
Currently pregnant or desire of pregnancy
Currently breastfeeding
Untreated thyroid disease
Untreated hyperprolactinemia
Type 1 or Type 2 diabetes
Women's Health
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Study Locations

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Location
Hershey, PA

Efficacy of Virtual Reality Exposure Therapy Scripts for Social Phobia

This research is conducted to test if virtual reality technology is effective to help people face their social fears and promote the use of adaptive social skills in various settings. You will be immersed in a range of virtual reality environments and work with a research therapist to learn certain skills, such as managing fears of negative evaluation during job interviews, and interacting with peers in common social settings (e.g., classrooms, cafeterias).
Hani Zainal at nvz5057@psu.edu or 814-863-0115
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Be at least 18 years old
Experiencing significant social anxiety
Able to read, write, and understand English
Not struggling with ongoing ongoing alcohol or substance use
Not actively suicidal
Exclusion Criteria:
Not interested in engaging in mental health treatment
Not socially anxious
Men's Health, Mental & Behavioral Health, Women's Health
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Study Locations

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Location
State College, PA

Understanding the Relationship between Education and Well-being among College Students with Disabilities

The purpose of the study is to gain an understanding of students’ experiences in college and their engagement help-seeking and healthy behaviors. Participation in the study involves completing a brief online-survey on Qualtrics, which we anticipate will take approximately 20 minutes to complete.
Amber O'Shea at amo5208@psu.edu or 814-867-5721
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Currently enrolled as a college student
18 years of age or older
Capable of providing informed consent
Diagnosis of a disability
Able to understand written English
Exclusion Criteria:
Adults unable to provide legal consent
Individuals who are not yet legal adults
Pregnant women
Prisoners
Education, Mental & Behavioral Health, Women's Health
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Coparenting, Infant Sleep, and Infant Development: An Intervention Study

This application proposes a randomized clinical trial (RCT) to evaluate the effects of a sleep-enhanced adaptation of an evidence-based transition-to-parenting coparenting intervention program [Family Foundations - FF). The study has three arms. In one arm, families will experience FF as originally formulated; in the second, families will receive an adapted FF that emphasizes coparenting in infant sleep contexts; the third arm will serve as controls. Assessments of coparenting and parenting in infant sleep contexts, parental adjustment to infant sleep behavior, choices about sleep arrangements, infant and parent sleep quality, and infant socio-emotional functioning, will serve as outcomes.
Morgan Loeffler at FF@psu.edu or 717-695-7050
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03187561
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Inclusion Criteria:
Parents must live together
Parents must be expecting their first baby together
We must start working with the couple before the baby is born
Parents must be 18 years or older
Families who can speak and understand English
Exclusion Criteria:
Single-parent families
Families with more than one-child
Familes who cannot speak or understand English
Families in which one parent is under the age of 18
Pregnancy & Infertility, Sleep Management, Women's Health
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Location
Carlisle, PA
Harrisburg, PA
Hershey, PA

The Daily Reflections Study

This 14-day daily diary study is being conducted to better understand how young adults' thoughts and feelings about their bodies influence their health behaviors, and how their daily experiences and characteristics contribute to their health behaviors. Participants will be asked to complete a 10-20 minute baseline survey and a brief (5-8 minutes) daily survey each day for 14 consecutive days. Surveys will include questions about participants' mental and physical health, emotions, relationships, health behaviors, thoughts, and experiences.
Anna Hochgraf at akh7@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Age 18-25 years
Enrolled in undergraduate degree program at Penn State
Access to internet between 8:00 AM and 12:00 PM
Proficient in English language
Exclusion Criteria:
Not between ages 18-25 years
Not enrolled in undergraduate degree program at Penn State
No access to internet between 8:00 AM and 12:00 PM
Not proficient in English language
Mental & Behavioral Health, Women's Health
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Zip-Stitch for Vaginal Cuff Closure in Laparoscopic Hysterectomy Safety &amp; Efficacy Study

This study will assess the safety and efficacy of the Zip-stitch System in maintaining vaginal cuff closure following laparoscopic hysterectomy. Participating subjects will be randomized and evaluated for implant passing, successful cuff closure, healing, adverse events and pain. Follow-up will involve in-person visits at approximately one week, six weeks, and six months. There will be an additional unblinded follow-up by telephone at 12 months post-operatively.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04081727
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Inclusion Criteria:
Women 18 years or older
Having a laparoscopic hysterectomy
Exclusion Criteria:
History of HIV, Hepatitis C, diabetes or known clotting defects or bleeding disorders
Active gynecological infection, sexually transmitted infection or pelvic inflamatory disease
Anemia
•Hemoglobin < 8g/dL
Pregnancy
Abnormal PAP results that have not been fully evaluated
Women's Health
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Location
Hershey, PA

The Influence of Estrogen-Status and Cardiorespiratory Fitness on Endothelial Signaling Pathways

Cardiovascular disease is the leading cause of death in women. Aerobic fitness is generally considered protective of vascular (blood vessel) health, but it is unclear whether this is true in postmenopausal women. The goal of this study is to understand whether aerobic fitness is beneficial for vascular health after menopause by evaluating signaling pathways that may be influenced by both menopause and fitness. Participants in this study will be healthy postmenopausal women who are either non-exercisers or regular exercisers. For the study, we will ask participants to complete 4 study visits at Penn State University. This will include health screenings, an exercise test, as well as measures of vascular health before and after 1 week of estrogen treatment.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Postmenopausal women (1-5 years postmenopausal)
50-60 years old
Regular Exerciser
Non-Exerciser
Healthy
Exclusion Criteria:
Cardiovascular Disease
Hormone Therapy Use or Long-term Menstrual Irregularities
High Blood Pressure or High Cholesterol
Smoker
Cardiovascular-related medications (blood pressure, cholesterol)
Heart & Vascular, Women's Health
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Study Locations

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Location
State College, PA

AWS-PSU: Active Women's Study at Penn State University

AWS-PSU: Active Women's Study at Penn State University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 16-29.9
No hormonal contraception for 6 months
Exclusion Criteria:
Smoking
Currently using medication impacting bone
Food & Nutrition, Muscle & Bone, Women's Health
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Study Locations

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Location
State College, PA

Inositol Supplementation to Treat Polycystic Ovary Syndrome: A Double Blind Dose Ranging RCT (INSUPP-PCOS)

Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women in the U.S. and is characterized by both reproductive (anovulation and androgen excess) and metabolic dysfunction (insulin resistance). PCOS lacks a simple, safe and effective treatment for women of all ages and all weights. Recently a dietary supplement, inositol, has been used widely to treat women with PCOS. However there are no well designed trials to address the risk/benefit ratio and identify the mechanism of action. In this study we propose a 3 month double blind (of both patients and investigators) randomized controlled trial of inositol supplementation compared to placebo. We hypothesis that women with PCOS who receive inositol supplementation will have a significantly greater reduction in serum total testosterone than women on placebo as well has improvement in glucose tolerance and decrease in fasting insulin.
Amyee McMonagle at amcmonagle@pennstatehealth.psu.edu
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Women 18-45 years old
Diagonosed with Polycystic Ovary Sydrome
Periods that last greater than or equal to 45 days OR a total of 8 or less per year
Exclusion Criteria:
High protactin levels
Uncorrected thyroid disease
Suspected adrenal or ovarian tumor screting androgens
Suspected Cushing's syndrome
Contraindications to the study drug or placebo
Women's Health
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Location
Hershey, PA

Management Of Pain After Cesarean Trial

This is a double blinded, placebo-controlled randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen and placebo on the patient's reported pain score on the second post-operative day after Cesarean delivery. We will also record opiate consumption and pain scores throughout the hospitalization of participants, and will survey patients at one and two weeks after surgery regarding opiate consumption and quality of life.
Female
All
This study is also accepting healthy volunteers
NCT03929640
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Inclusion Criteria:
Pregnant woman
Planned delivery via C-section
Pfannenstiel ("bikini line") skin incision
Able to read and speak English fluently
Exclusion Criteria:
Major intra-operative or post-operative complication such that clinical recommends patient should not receive non-steroidal anti-inflammatory drugs
Unplanned surgery (hysterectomy, bowel/bladder repair, cystoscopy)
Allergy or contraindication to study medication
History of opioid or other substance use disorder either before or during pregnancy
History of kidney or liver disease
Pregnancy & Infertility, Women's Health
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Location
Hershey, PA

Functional and Mechanical Changes Following Total Ankle Arthroplasty

Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle. The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
No recent history (< 1 year) of injuries to Achilles tendon
No history of lower limb reconstruction or surgery
age 70 year or older
Exclusion Criteria:
History of any previous surgery to lower limb
History of rheumatoid arthritis or other degenerative joint disease
Non English speaking
Inability to provide consent
Men's Health, Muscle & Bone, Women's Health
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Study Locations

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Location
State College, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT02822378
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Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
Food & Nutrition, Muscle & Bone, Women's Health
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Location
State College, PA

Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In total, participants are required to visit the research lab on the University Park campus a total of five times. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 814-867-2333
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18-55 years of age
Right Handed
Smokes cigarettes
Exclusion Criteria:
under 18 years of age or over 55 years of age
Left Handed
non-smokers
Men's Health, Addiction & Substance Abuse, Women's Health
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Study Locations

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Location
Altoona, PA
State College, PA

SPIRIT 1: An International Phase 3 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study to Evaluate Relugolix Administered with and without Low-Dose Estradiol and Norethindrone Acetate in Women with Endometriosis-Associated Pain

Endometriosis is a common chronic condition that can cause pain in the lower part of the stomach (pelvis) during the menstrual period and at other times and pain during sexual intercourse. The purpose of this study is to test how effective and safe the investigational study drug, relugolix (rel-U-GO-lix), given with or without low-dose estradiol and norethindrone is in treating endometriosis-associated pain. Estradiol is a form of estrogen and norethindrone is form of progesterone. Both estrogen and progesterone are hormones normally made by women’s bodies. These hormones help control the menstrual cycle and menstrual periods and also support bone health. The study wants to know if endometriosis pain affects how women function, how they feel and if the study drug is effective and safe at treating the pain from endometriosis.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03204318
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Inclusion Criteria:
Premenopausal female aged 18 to 50 years old
Has a diagnosis of endometriosis verified by surgery in the last 10 years
Has regular menstrual cycles (21 to 35 days long)
Has moderate, severe, or very severe pain during menstrual cycles
Is not expected to undergo gynecological surgery (or other surgical procedures for treatment of endometriosis) during the study
Exclusion Criteria:
Has a history of chronic pelvic pain that is not caused by endometriosis
Has had 4 or more prior laparoscopic, surgical, or other invasive procedure for endometriosis
Has had gynecological surgery or other surgical procedures for treatment of endometriosis within the 3 months prior to the Screening visit
Has unexplained vaginal bleeding outside of the patient’s regular menstrual period or pregnancy
Has a gastrointestinal disorder affecting absorption or gastrointestinal motility, history of or currently has osteoporosis or a systemic autoimmune disease
Pain Management, Women's Health
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Location
Hershey, PA

Feasibility Study Phase C: Expansion in Multiple Institutions for Training in the Use of the LUM Imaging System for Intraoperative Detection of Residual Cancer in the Tumor Bed of Female Subjects with Breast Cancer

The main goal of standardizing the training for surgeons and clinical staff that will be participating in the anticipated pivotal study of the Lumicell Imaging System. Identify and address any site-specific or user-specific issues for using the LUM Imaging System in breast cancer patients and to collect safety and efficacy data.
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02438358
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Inclusion Criteria:
Female, age of 18 years or older
Cytology confirmed primary invasive breast cancer, ductal carcinoma in situ or a combination of both
Scheduled for lumpectomy for a breast malignancy
No uncontrolled serious medical problems
Exclusion Criteria:
Subjects who are pregnant at the time of breast cancer diagnosis
Uncontrolled hypertension or other uncontrolled medical problems
Patient who is sexually active and not willing to use contraception-hormonal or barrier method, or abstinence for 60 days after injection
Individuals undergoing a second lumpectomy because of previous positive margins
Subjects who have taken an investigational drug in the 30 days prior to enrollement
Cancer, Women's Health
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Location
Hershey, PA

Long-Term Nicotine Treatment of Mild Cognitive Impairment

The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in people experiencing mild memory problems (referred to in this study as “mild cognitive impairment” or MCI). Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain. This chemical substance, acetylcholine, is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our attention. In people with MCI (and Alzheimer’s disease), the level of acetylcholine may be changed, and this may impair brain functioning. Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimer’s disease (AD). It has been known for many years that nicotine imitates many of the actions of acetylcholine. By administering nicotine over a longer period of time to participants with MCI, we hope to better understand whether nicotine may act to improve memory loss symptoms over the longer term and whether it may help to delay the progression of memory loss symptoms. The amount of nicotine in each patch used in this study is the same as patches that are FDA approved for use in people who are trying to quit smoking.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02720445
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Inclusion Criteria:
Patient must have a subjective memory concern as reported by patient, study partner, or clinician
Age 55-90 (inclusive)
Study Partner is available who has frequent contact with the patient (e.g. an average of 10 hours per week or more), and can accompany the patient to most visits to answer questions about the patient
Must speak English fluently
Good general health with no additional diseases/disorders expected to interfere with the study
Exclusion Criteria:
Any use of tobacco or nicotine products within the past year
Any significant neurologic disease such as Alzheimer’s disease dementia, Parkinson’s disease, multi-infarct dementia, brain tumor, seizure disorder, etc.
History of alcohol or substance abuse or dependence within the past 2 years
Men's Health, Neurology, Women's Health
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Location
Hershey, PA

Exploring Facilitators and Barriers to Self-Initiated Sexually Transmitted Infection Testing among College Student

The purpose of this study is to identify modifiable facilitators and barriers to self-initiated sexually transmitted infection (STI) testing among college students aged 18 – 24 years. This study will entail filling out a demographic and sexual history questionnaire, and a private face-to-face interview.
Oluwamuyiwa Adebayo at DAresearch@psu.edu or 814-867-4656
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
aged 18 – 24
able to speak and understand English language fluently
able to provide written informed consent
engaged in sexual activity in the past 6 months
fit into either study Group I (self-initiated STI testing) or Group II (never tested for STI) or Group III (Clinician-initiated)
Exclusion Criteria:
Not meeting all the inclusion criteria
Infectious Diseases & Immune System, Men's Health, Women's Health
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Location
Altoona, PA
Harrisburg, PA
Hershey, PA
State College, PA
Williamsport, PA

Examining Maternal Reward Responsiveness and the Intergenerational Risk for Depression

Children of depressed mothers are at high risk for developing depression, particularly as youth age into adolescence, yet relatively little is known about the mechanism underlying risk for depression in youth with depressed mothers. The present study examines maternal reward responsiveness, measured across neurophysiological, behavioral, and self-report measures as a marker of depression in mothers of adolescents. Associations between maternal reward responsiveness and parenting difficulties often associated with maternal depression, as well as adolescent functioning will be examined, to explore the clinical impact of maternal reward responsiveness on the intergenerational transmission of depression.
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Female adults 18 years and above with an adolescent child aged 13-16 years
Capacity for informed consent
Fluent in verbal and written English
Adolescent between the ages of 13 and 16 years (inclusive)
Exclusion Criteria:
Diagnosis of autism spectrum disorder, substance use disorders, schizophrenia or other psychotic disorder
Any hearing or visual impairments
Investigator discretion regarding ability to participate in the study
Children's Health, Mental & Behavioral Health, Women's Health
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Location
Hershey, PA

Postmenopausal women and their endothelium: Is acute dietary nitrate supplementation protective?

Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development. The purpose of this study is to test the effects of a one time dose of beetroot juice on blood vessel function and resting blood pressure in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.
Yasina Somani at yfs5057@psu.edu or 814-954-2930
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03644472
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Inclusion Criteria:
Women within 1-5 years following menopause
Exclusion Criteria:
Individuals taking hormone therapy
Individuals with resting blood pressure > or = 130/80 mmHg
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
Food & Nutrition, Heart & Vascular, Women's Health
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State College, PA

Neurocomputational Mechanisms of Affiliation and Personality (NeuroMAP)

This study seeks to learn how brain changes in young adults may be related to the development of interpersonal and emotional functioning, as well as risky behavior. This research is being done to find out the differences in the ways that emerging adults regulate their emotions and behavior and how this is reflected in computer-based tasks and fMRI.
Begonia Herbert-Ramirez at bbh5255@psu.edu or 814-863-7624
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-25 years old
Weigh less than 250 lbs.
Fluent English speaker
Exclusion Criteria:
Metal in body
Neurological disorder (autism, developmental disorder)
Current pregnancy
Less than 20/40 far acuity (corrected or uncorrected)
Men's Health, Mental & Behavioral Health, Women's Health
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State College, PA

A randomized, double-blind, placebo-controlled, phase 2 trial assessing the efficacy, safety and dose-response of quinagolide extended-release vaginal rings administered sequentially for 8 menstrual cycles in women with moderate to severe endometriosis-related pain

To evaluate the efficacy of three doses of quinagolide administered as an extended-release vaginal ring compared to placebo on reduction of moderate to severe endometriosis-related pain
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03692403
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Inclusion Criteria:
Diagnosis of endometriosis
pre-menopausal females age 18 and over
history of regular menstrual cycles
moderate to severe endometriosis related pain
Exclusion Criteria:
pregnant or breastfeeding
chronic pelvic or abdominal, or lower back pain not related to endometriosis
history of recurrent bacterial or fungal vaginal infection
current use of hormonal medication will require a washout period
Women's Health
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Hershey, PA

Comparing barriers to cancer screening across PSCI catchment area county types: Implications for a self-sampling intervention – Patient surveys

In this study, we will conduct surveys with women, ages 45-65 years, who are patients in the Penn State Cancer Institute (PSCI) catchment area which includes rural/urban and segregated/not segregated counties in Pennsylvania to learn more about their barriers to cancer screening.
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Female residing within the PSCI catchment area
45-65 years of age
Able to speak, read, and communicate well in English
Exclusion Criteria:
Children
Cognitively impaired
Cancer, Women's Health
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A Phase 3 multicenter, randomized, double-blind, placebo-controlled, clinical study to assess the efficacy and safety of linzagolix in subjects with moderate to severe endometriosis-associated pain.

The purpose of this study is to look at the safety and efficacy of different doses of linzagolix alone and together with so-called ‘add-back therapy’ (hormones) compared to placebo (an inactive sugar pill) in women with moderate to severe pain associated with endometriosis. Endometriosis is when tissue that normally grows inside the uterus grows outside the uterus. It is one of the most common gynecological diseases. The condition is mainly found in women in their reproductive years and disappears spontaneously after menopause. Symptoms can include painful periods, chronic pelvic pain, pain with bowel movement, pain during intercourse and urination problems. Linzagolix is an experimental drug which is not approved for the treatment of moderate to severe pain associated with endometriosis. Linzagolix has been shown to significantly reduce pain associated with endometriosis in women with endometriosis at once daily doses between 50 and 200 mg with a good safety and tolerability profile. About 450 women will take part in this study at a number of different locations in the US and Canada. This study will have up to 16 study visits over a period of approximately 15 months.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03986944
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Inclusion Criteria:
Women aged 18
•49 years old
Has had surgery to diagnose endometriosis up to 10 years before screening
Has moderate to severe endometriosis associated pain
Must agree to take only those pain medications permitted by the study during participation
Exclusion Criteria:
Pregnant, planning to become pregnant or breastfeeding. If recently pregnant, must be at least 6 months post-partum or 3 months post-abortion/miscarriage
Surgical history of hysterectomy, Essure device, endometrial ablation resulting in amenorrhea, both ovaries removed, bowel resection or gastric bypass
Has had surgery for endometriosis in the last 6 months or planning surgery for endometriosis during study participation
Chronic narcotic use, alcohol or illicit drug abuse or prescribed medical marijuana
Pain Management, Women's Health
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Hershey, PA

M16-824 A phase 3 Study to Evaluate the Safety and Efficacy of Elagolix for the Management of Heavy Menstrual Bleeding Associated with Uterine Fibroids in Premenopausal Women.

The purpose of this study is to determine the safety and effectiveness of elagolix 150 mg once daily and how this dosage of elagolix works when compared to placebo in reducing heavy menstrual bleeding, the major symptom of uterine fibroids. Elagolix is an investigational drug which suppresses the production of estrogen depending on the dose. Because Elagolix can reduce the estrogen below the normal level, it is being tested for the treatment of symptoms of endometriosis and uterine fibroids, two conditions are that hormone-dependent. Participation in this study will last approximately up to 22 months and include approximately 10-12 study visits to the research center and approximately 4 visits that will be conducted over the phone.
Erin Hammett at ehammett@pennstatehealth.psu.edu or 717-531-1510
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03886220
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Inclusion Criteria:
Premenopausal women, 18
•51 years old
Diagnosis of uterine fibroids with heavy menstrual bleeding
Regular menstrual cycles between 24
•38 days in length
Must agree to use at least 2 forms of non-hormonal contraception throughout the study period.
Exclusion Criteria:
No osteoporosis or other metabolic bone disease
No history of suicide ideation or attempts
Not currently pregnant, breastfeeding or planning to become pregnant until study completion
Women's Health
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Hershey, PA

Centre County COVID-19 Data 4 Action Study

The purpose of this research is to evaluate the extent of COVID-19 risk and perceived risk among Centre County residents and students, and how those risks evolve from the time isolation guidelines were implemented through a return to normal functioning. Participants in this research will complete an electronic survey with questions about their demographic, about their exposure to COVID-19, and about how COVID-19 has affected their health and work/education. Data from this research will be used to inform Centre County planning authorities and the Pennsylvania State University about the needs of communities, including needs for information dissemination and for potentially actionable, local interventions in response to the COVID-19 pandemic.
Susan McHale at src-ssri@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years of age.
Currently living in Centre County, PA.
Expect to continue living in Centre County, PA (through at least Sept 2020)
Capable of providing your own informed consent.
Exclusion Criteria:
No additional exclusion criteria beyond those required for inclusion.
Infectious Diseases & Immune System, Men's Health, Women's Health
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The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.

The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program. The aims of the PRIDE Program are to: 1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure. 2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants. 3. Establish a mechanism for approving use of the banked biospecimens for future research.
Syndi Reed at creed@pennstatehealth.psu.edu or 855-369-3540
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Any age
Ability of patient, child and/or parent to understand or complete the consent process
Exclusion Criteria:
Unable to understand or complete the consent process
Opted out of research studies
Men's Health, Children's Health, Women's Health
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Hershey, PA

Comparing barriers to cancer screening across PSCI catchment area county types: Implications for a self-sampling intervention – Patient Focus Groups

In this study, we will conduct focus groups with women, ages 45-65 years, who are patients in the Penn State Cancer Institute (PSCI) catchment area which includes rural/urban and segregated/not segregated counties in Pennsylvania to learn more about their barriers to cancer screening
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Female residing within the PSCI catchment area
45-65 years of age
Able to speak, read, and communicate well in English
May also participate in the "Comparing barriers to cancer screening across PSCI catchment area county types: Implications for a self-sampling intervention – Patient surveys" study
Exclusion Criteria:
Children
Cognitively impaired
Imprisoned
Complete hysterectomy
History of cervical or colorectal cancer
Cancer, Women's Health
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Hershey, PA
York, PA