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Study matches: 20

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


The Sexual Relationships Study

The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following: Aim 1. Examine the heterogeneity in relationship quality among female college students. Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence? Aim 2. Examine the association between relationship characteristics and latent class membership. Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality? Aim 3. Examine the association between latent classes of relationship quality and condom use. Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex? Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Jessica Salas-Brooks at jis5940@psu.edu or 7042494252
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Be enrolled at Pennsylvania State University (University Park Campus)
Be between the ages of 18-22 years
Be a female college student
Be sexually active with male partners in the previous 3 months
Exclusion Criteria:
Are not enrolled at Pennsylvania State University (University Park Campus)
Are under the age of 18 or over the age of 22.
Are not a female college student
Are not sexually active with male partners in the previous 3 months
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N/A
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

This study is for patients who have been diagnosed with moderate to severe ulcerative colitis (UC) who are experiencing bloody diarrhea, abdominal pain, and a sudden and constant feeling of needing to move their bowels. Additionally, patients have been unable to tolerate or have had an insufficient response to treatment with medications that help reduce inflammation associated with UC. This research is being done to evaluate the safety of different doses of ABT-494 (study medication) and determine how well it works, as well as how the study medication is absorbed, distributed and eliminated in the body over time.
Amy Behe at abehe@pennstatehealth.psu.edu or 814-689-0014
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of ulcerative colitis for at least 90 days
Demonstrated an inadequate response to, loss of response to, or intolerance to steroids, immunosuppressants and/or biologic therapies
Exclusion Criteria:
Have a current diagnosis of Crohn's disease, fulminant colitis and/or toxic megacolon
History of total colectomy or ileostomy
Taking a probiotic and has not been on a stable dose for at least 10 days
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NCT02819635
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State College, PA

Role of angiotensin II and inflammation in persistent vessel dysfunction following preeclampsia

The purpose of this study is to determine what contributes to blood vessel damage during and immediately following a preeclamptic pregnancy. To do this, we examine blood vessel function in the small vessels in the skin. Understanding what contributes to these impairments may lead to better treatments and/or prevention strategies for vessel dysfunction in women who have or had preeclampsia. Two groups of subjects will be enrolled in this study: women who have delivered within 1 year and who have had a preeclamptic pregnancy diagnosed by their obstetrician, and women who have delivered within 1 year and did not have preeclampsia.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
had a baby in the last 12 months
had preeclampsia or did not have preeclampsia
Exclusion Criteria:
had gestational diabetes
history of hypertension prior to pregnancy
current tobacco use
currently pregnant
currently taking medication to lower cholesterol
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N/A
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State College, PA

Cyclic Variation in Micronutrient Concentrations and Plasma Volume in Reproductive-Age Women

In this study, we will examine how the menstrual cycle influences micronutrient concentrations in women of reproductive age. We will also examine how the menstrual cycle affects plasma volume in these women. Finally, we will assess the relationship between plasma volume and micronutrient concentrations among study participants. This study involves three visits to the Clinical Research Center (CRC) located in Noll lab, University Park. To participate, interested women will contact the study coordinator via phone or email and provide their name and phone number. A member from the PI lab will contact the interested participant to screen her for eligibility. If a participant is eligible, she will be scheduled to visit the CRC, where eligibility will be confirmed. To confirm eligibility, we will measure her weight, height, blood pressure and conduct a pregnancy test. If eligible, we will conduct hydration test, and measure body composition, then she will complete a short questionnaire about her pregnancy histories and health. She will then rest on bed for 15 to 20 minutes and the nurse will insert an IV to draw some blood ~15mL. Then the nurse will inject her with a small amount of a green dye followed by a series of blood draws (total ~15mL) within the next 5 minutes. She will relax on the bed or sit on a chair for 15 minutes to be monitored by the nurse, to be sure that she is okay. Then we will provide her with a home-based fertility monitor to be used to track her menstrual cycle. We will instruct her on how to use her urine sample to track daily changes in some targeted reproductive hormones during the cycle. The results are displayed in a simple to read format from the monitor. We will use the readings from this monitor to schedule visit 2 (~ day 12 of her cycle). After visit 2, the participant will conduct a few more urine test at home and the results of those tests will be used to schedule her final last visit (~ day 21 of her cycle). On the 2nd and 3rd visits, we will again measure her weight, height, blood pressure and conduct pregnancy to confirm that the participant is still eligible. If we confirm she is still eligible, we will complete the rest of the measurements as in visit one. Blood samples at each visit will be processed and stored at -80C until the data collection is completed. Plasma samples will be processed same day to determine the subject’s plasma volume.
Sixtus Aguree at sua204@psu.edu or 814-867-5938
Female
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Female
18 to 44 years of age
General good health (does not have a known, ongoing health condition/medical issue that requires regular monitoring by a doctor or regular visits to the hospital)
BMI 18.5-24.9 kg/m2
Regular menstrual cycle (26-35 days) & currently non-pregnant
Exclusion Criteria:
Known allergy to shellfish or iodine
Currently using hormonal birth control or used within last 3 months
Blood pressure on the day of measurements is low or high (SBP <100 or >140 mmHg and/or DBP <60 or >90 mmHg)
Current hypertension or previous hypertensive disorder in pregnancy (gestational hypertension or preeclampsia)
Currently trying to conceive
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Location
State College, PA

A Phase 3, Multicentre, randomized, double-blind, placebo-controlled study investigating the efficacy and safety of daily oral administration of OBE2109 alone and in combination with add-back therapy for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.

To evaluate the safety and efficacy of OBE2109 alone and in combination with add-back therapy versus placebo on reduction of heavy menstrual bleeding, hemoglobin levels, pain, fibroid symptom severity, and health related quality of life in pre-menopausal women with uterine fibroids.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
premenopausal woman aged 18 years or above
presence of uterine fibroid/s
experiences abnormal heavy menstrual bleeding
menstrual cycles ≥ 21 days and ≤ 40 days
not seeking pregnancy within the next year
Exclusion Criteria:
Partial or total hysterectomy
history of deep vein thrombosis, pulmonary embolism, arterial thromboembolic disease
history of or current uterine, cervical, ovarian, breast cancer
pregnant or breastfeeding or planning pregnancy in the next 1.5 years
positive screening test for HIV or hepatitis
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NCT03070899
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Hershey, PA

Gestational transmission of HPV from mother to fetus

HPV infections induce changes in the female genital tract, apoptosis in embryonic cells, and miscarriages or premature rupture of the membranes. Importantly, pregnant women are more susceptible to HPV infections due to the relative immunosuppression experienced during pregnancy. HPV-induced Recurrent Respiratory Papillomatosis (RRP) is believed to result from HPV transmission from mothers to newborns as a result of passage through the birth canal. RRP is a highly morbid pathological condition among children. It is characterized by the recurrent appearance of wart-like lesions in the respiratory tract, particularly at the larynx and vocal cords. These patients must undergo repeated surgery or other invasive treatment to manage the disease. Whether HPV infections play a role in infertility and childhood RRP in the Central Pennsylvania is unknown.
Heidi Reinhard at hreinhard@pennstatehealth.psu.edu or 717-531-5166
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Pregnant
Exclusion Criteria:
Not pregnant
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N/A
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AWS-PSU: Active Women's Study at Penn State University and AWS-Lincoln: Active Women’s Study Lincoln University

AWS-PSU: Active Women's Study at Penn State University and Lincoln University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Emily Southmayd at eas5377@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 18 and 30
No hormonal contraception for 6 months
Exclusion Criteria:
Smoking
Currently using medication impacting bone
Current diagnosis of an eating disorder
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N/A
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State College, PA

E-cigarette Use among College-Age Individuals in Association with Biomarkers of Bone Health

Vitamin D and cigarette use are well-known to influence bone health. However, we know little about whether e-cigarettes may also play a role. We invite you to help us learn more about whether e-cigarette use may influence vitamin D levels and/or bone health. Participation requires one in-person visit (approximately 20 minutes in length) and questionnaire completion (approximately 40 minutes in length).
Cyndi Flanagan at chf117@psu.edu or 814-863-7126
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age 18 to 35
Female
e-Cigarette User
Exclusion Criteria:
Cancer
Liver Disease
Kidney Disease
Taking Drugs that Interfere with Vitamin D Metabolism
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N/A
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Location
State College, PA

A Phase 3b Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Combination with Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated with Uterine Fibroids in Premenopausal Women

The objectives of this study are to assess the long term efficacy and safety of elagolix alone and elagolix in combination with add back therapy to reduce heavy menstrual bleeding associated with uterine fibroids and characterize the impact on bone density after up to 2 years of treatment.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
premenopausal female
age 18-48
uterine fibroids or suspected uterine fibroids
heavy menstrual bleeding
regular monthly menstrual periods
Exclusion Criteria:
menstrual periods greater than 38 days apart
history of major depression or PTSD in the past 2 years
history of osteoporosis or other metabolic bone disease
planning pregnancy within the next 2 years
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NCT03271489
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Location
Hershey, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
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NCT02822378
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State College, PA

Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In total, participants are required to visit the research lab on the University Park campus a total of five times. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 8148672333
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
18-55 years of age
Right Handed
Smokes cigarettes
Exclusion Criteria:
under 18 years of age or over 55 years of age
Left Handed
non-smokers
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N/A
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Location
Altoona, PA
State College, PA

Evaluation of Vitamin D With And Without Hormonal Contraception on Sexual Function in Women With Polycystic Ovary Syndrome

To evaluate the prevalence of sexual dysfunction (SDy) in women with Polycystic Ovarian Syndrome (PCOS) and to determine the effects of Vitamin D therapy, with and without hormonal contraceptives, on SDy in women with PCOS in the absence of depression.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
women aged 18-40 years
Diagnosed with polycystic ovarian syndrome (PCOS)
Exclusion Criteria:
Chronic illness such as diabetes or hypertension
Severe depression
Thyroid dysfunction
Elevated prolactin levels
history of venous embolism
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NCT02865187
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Hershey, PA

SPIRIT 1: An International Phase 3 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study to Evaluate Relugolix Administered with and without Low-Dose Estradiol and Norethindrone Acetate in Women with Endometriosis-Associated Pain

Endometriosis is a common chronic condition that can cause pain in the lower part of the stomach (pelvis) during the menstrual period and at other times and pain during sexual intercourse. The purpose of this study is to test how effective and safe the investigational study drug, relugolix (rel-U-GO-lix), given with or without low-dose estradiol and norethindrone is in treating endometriosis-associated pain. Estradiol is a form of estrogen and norethindrone is form of progesterone. Both estrogen and progesterone are hormones normally made by women’s bodies. These hormones help control the menstrual cycle and menstrual periods and also support bone health. The study wants to know if endometriosis pain affects how women function, how they feel and if the study drug is effective and safe at treating the pain from endometriosis.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 7175316272
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Premenopausal female aged 18 to 50 years old
Has a diagnosis of endometriosis verified by surgery in the last 10 years
Has regular menstrual cycles (21 to 35 days long)
Has moderate, severe, or very severe pain during menstrual cycles
Is not expected to undergo gynecological surgery (or other surgical procedures for treatment of endometriosis) during the study
Exclusion Criteria:
Has a history of chronic pelvic pain that is not caused by endometriosis
Has had 4 or more prior laparoscopic, surgical, or other invasive procedure for endometriosis
Has had gynecological surgery or other surgical procedures for treatment of endometriosis within the 3 months prior to the Screening visit
Has unexplained vaginal bleeding outside of the patient’s regular menstrual period or pregnancy
Has a gastrointestinal disorder affecting absorption or gastrointestinal motility, history of or currently has osteoporosis or a systemic autoimmune disease
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NCT03204318
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Hershey, PA

Feasibility Study Phase C: Expansion in Multiple Institutions for Training in the Use of the LUM Imaging System for Intraoperative Detection of Residual Cancer in the Tumor Bed of Female Subjects with Breast Cancer

The main goal of standardizing the training for surgeons and clinical staff that will be participating in the anticipated pivotal study of the Lumicell Imaging System. Identify and address any site-specific or user-specific issues for using the LUM Imaging System in breast cancer patients and to collect safety and efficacy data.
Stephanie Gorrell at sgorrell@pennstatehealth.psu.edu or 717-531-0003, x286789
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Female, age of 18 years or older
Cytology confirmed primary invasive breast cancer, ductal carcinoma in situ or a combination of both
Scheduled for lumpectomy for a breast malignancy
No uncontrolled serious medical problems
Exclusion Criteria:
Subjects who are pregnant at the time of breast cancer diagnosis
Uncontrolled hypertension or other uncontrolled medical problems
Patient who is sexually active and not willing to use contraception-hormonal or barrier method, or abstinence for 60 days after injection
Individuals undergoing a second lumpectomy because of previous positive margins
Subjects who have taken an investigational drug in the 30 days prior to enrollement
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NCT02438358
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Hershey, PA

Reward function as a mechanism linking personality and intermittent smoking

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. The study requires one visit to the lab that lasts approximately three hours. In order to be eligible for the study, individuals must be between 18 and 25 years and must smoke on some (but not all) days.
Melinda Ashe at mla233@psu.edu or (814) 867-2333
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
18-25 years of age
Right handed
Native English speaker
Smoke cigarettes on some (but not all) days
Exclusion Criteria:
Attempting to quit smoking
Serious cardiovascular or respiratory disease
MRI conraindications
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N/A
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Altoona, PA
State College, PA

The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.

The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program. The aims of the PRIDE Program are to: 1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure. 2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants. 3. Establish a mechanism for approving use of the banked biospecimens for future research.
Syndi Reed at creed@pennstatehealth.psu.edu or 855-369-3540
All
Not specified
This study is also accepting healthy volunteers
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Inclusion Criteria:
Any age
Ability of patient, child and/or parent to understand or complete the consent process
Exclusion Criteria:
Unable to understand or complete the consent process
Opted out of research studies
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N/A
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Location
Hershey, PA

The Effect of a Mixed-Composition Meal on Thermic Effect of Food, Fuel Utilization, Subjective Appetite, and Appetite Hormone Responses in Young Exercising Women across the Body Mass Index Spectrum

The Women’s Health and Exercise Laboratory is seeking research participants for a study investigating the metabolic, hormonal, and psychological effects of a meal in women. In addition to being monetarily compensated, participants will receive an analysis of their diet, hormone levels, metabolism, and body composition. Participants should be: Female, healthy 18-35 year old, non-smoking, with a BMI between 16-35 kg/m2, have not had a menstrual period in the last 3 months, and not taking hormonal contraceptives. OR Female, healthy, 18-35 year old, moderately overweight (BMI 25-35 kg/m2), non-smoking, regular menstrual cycles for the past 6 months and are not taking hormonal contraceptives. This study is under the direction of Drs. Nancy Williams and Mary Jane De Souza (Department of Kinesiology) and requires regular visits (4-5 visits) to Noll Laboratory on the University Park campus over approximately 2 months. For more information please call (814) 863-4488, or email WHEL@psu.edu
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age 18-35
Exercising at least 1 hr/wk
Overweight (BMI 25-35 kg/m2)
If normal weight: no menstrual cycle for at least 3 months
Exclusion Criteria:
Hormonal contraception use in past 6 months
Smoking
If normal weight: regular menstrual cycle
If overweight: menstrual irregularity
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N/A
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State College, PA

Young Adults Dating Online with a Disability

The purpose of this qualitative study is to learn about the online dating experiences of 25 young adults (ages 18-30) in the US using surveys.
Elizabeth Mazur at emazur@psu.edu or 4126759186
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Between ages 18-30
Have a physical, sensory, emotional, and/or cognitive disability or impairment
) Have tried an online dating app or website at least once (such as, but not limited to, Tinder, Bumble, Zoosk, Grindr, Glimmer, Match.com, Dating4disabled, etc.).
Exclusion Criteria:
Younger than 18 or older than 30
Lack of a physical, sensory, emotional, and/or cognitive disability or impairment
Have never tried online dating
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Standardization and normative data of the symbol digit modalities test (SDMT) - oral version

The symbol digit modalities test (SDMT) is a paper test given to people to see how quickly they process information. The purpose of this research study is establish updated accurate data on healthy individuals to use as a comparison for cognitive (thinking) impairment associated with Multiple Sclerosis (MS). Study is currently looking for individuals age 25-74 with less than four years of college education.
Erin Guty at exg5204@psu.edu or 814-865-5578
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Between ages of 25-74
Less than 4 years of college education
Less than Bachelor's Degree
Medically Healthy
Exclusion Criteria:
Significant mental health disorder (e.g. bipolar, psychosis)
Diagnosed learning disability or ADHD
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N/A
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Location
Altoona, PA
State College, PA

A Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Combination with E2/NETA in Subjects with Moderate to Severe Endometriosis Related Pain

A Phase 3 24 month study to evaluate the safety and efficacy of elagolix in combination with add back therapy in the management of of endometriosis associated pain in premenopausal women
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Premenopausal women age 18-49
documented diagnosis of endometriosis within the past 10 years
regular menstrual cycles (every 21-38 days)
endometriosis related pain
Exclusion Criteria:
pregnant or breastfeeding, or planning a pregnancy within the next two years
hysterecctomy or oophorectomy
History of major depression or post traumatic stress disorder
any form of chronic pain syndrome requiring chronic analgesic therapy
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NCT03213457
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Location
Hershey, PA