Search Results within category "Women's Health"
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The Sexual Relationships Study
The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following:
Aim 1. Examine the heterogeneity in relationship quality among female college students.
Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence?
Aim 2. Examine the association between relationship characteristics and latent class membership.
Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality?
Aim 3. Examine the association between latent classes of relationship quality and condom use.
Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex?
Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Jessica Salas-Brooks at jis5940@psu.edu or 704-249-4252
Female
18 year(s) or older
N/A
Women's Health
Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis
Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women.
Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
N/A
Heart & Vascular, Pregnancy & Infertility, Women's Health
Site For COMET-PCOS
Site For COMET-PCOS
Patsy Rawa at prawa@pennstatehealth.psu.edu or 717-531-3692
Female
18 year(s) or older
NCT03229057
Women's Health
Efficacy of Virtual Reality Exposure Therapy Scripts for Social Phobia
This research is conducted to test if virtual reality technology is effective to help people face their social fears and promote the use of adaptive social skills in various settings. You will be immersed in a range of virtual reality environments and work with a research therapist to learn certain skills, such as managing fears of negative evaluation during job interviews, and interacting with peers in common social settings (e.g., classrooms, cafeterias).
Hani Zainal at nvz5057@psu.edu or 814-863-0115
All
18 year(s) or older
NCT04850989
Men's Health, Mental & Behavioral Health, Women's Health
Understanding the Relationship between Education and Well-being among College Students with Disabilities
The purpose of the study is to gain an understanding of students’ experiences in college and their engagement help-seeking and healthy behaviors. Participation in the study involves completing a brief online-survey on Qualtrics, which we anticipate will take approximately 20 minutes to complete.
Amber O'Shea at amo5208@psu.edu or 814-867-5721
All
18 year(s) or older
N/A
Education, Mental & Behavioral Health, Women's Health
Coparenting, Infant Sleep, and Infant Development: An Intervention Study
This application proposes a randomized clinical trial (RCT) to evaluate the effects of a sleep-enhanced adaptation of an evidence-based transition-to-parenting coparenting intervention program [Family Foundations - FF). The study has three arms. In one arm, families will experience FF as originally formulated; in the second, families will receive an adapted FF that emphasizes coparenting in infant sleep contexts; the third arm will serve as controls. Assessments of coparenting and parenting in infant sleep contexts, parental adjustment to infant sleep behavior, choices about sleep arrangements, infant and parent sleep quality, and infant socio-emotional functioning, will serve as outcomes.
Morgan Loeffler at FF@psu.edu or 717-695-7050
All
18 year(s) or older
NCT03187561
Pregnancy & Infertility, Sleep Management, Women's Health
Behavior, Voice, and Sex Hormones Study
Hormones are molecules that deliver signals throughout the body. They influence behavior, sleep, hunger, stress, and virtually all other aspects of life. This study seeks to better understand several of these functions, specifically how hormones affect specific aspects of human behavior and psychology, as well as speech production. Following an initial lab visit, subjects will participate in the remainder of the study (~5 weeks) at home via the internet. On a daily basis, they will collect urine samples for hormone analysis, saliva samples for analysis of oral micro-organisms, and will submit voice samples for analysis of speech (e.g. measuring voice pitch and loudness). They will then complete an online survey designed to collect information about their behavior, and attitudes over the previous 24 hours. Subjects receive compensation for their participation.
Kevin Rosenfield at kar61@psu.edu
Female
18 year(s) or older
N/A
Language & Linguistics, Diabetes & Hormones, Women's Health
Endometriosis and microvascular dysfunction 3
Endometriosis, is a disorder that occurs in women, is when tissue that should be normally found inside the womb is also found in sites outside of the womb. Endometriosis is a disorder that is associated with systemic inflammation. This disorder impairs the function of the endothelium, the cells that line the body’s blood vessels (endothelium). The endothelium helps to control blood flow in healthy vessels. Women with endometriosis not only have an increased risk for high blood pressure and high cholesterol, they also have an increased risk for cardiovascular disease. With this study, we will learn how systemic inflammation in endometriosis impairs the lining of blood vessels and increases the risk for cardiovascular disease.
We will use a short term intervention with a non-steroidal anti-inflammatory to examine how inflammation impact endothelial function in women with endometriosis
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
N/A
Heart & Vascular, Pregnancy & Infertility, Women's Health
Mindful Moms study
The primary aim of this randomized pilot study (Mindful Moms) is to examine the effects of an 8-week mindfulness meditation intervention delivered via a commercially available mobile app (Calm) on maternal breastfeeding duration and well-being.
Amy Moore at amm9107@psu.edu or 814-865-6714
Female
18 year(s) or older
N/A
Food & Nutrition, Pregnancy & Infertility, Women's Health
Perspectives on Contraception Requirements and Pregnancy Exclusions in Clinical Trials
This is a survey study that will examine the perspectives of reproductive aged men and women on contraception requirements and pregnancy exclusions in clinical trials.
Sarah Hershberger at shershberger@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Men's Health, Pregnancy & Infertility, Women's Health
AWS-PSU: Active Women's Study at Penn State University
AWS-PSU: Active Women's Study at Penn State University
This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
N/A
Food & Nutrition, Muscle & Bone, Women's Health
Inositol Supplementation to Treat Polycystic Ovary Syndrome: A Double Blind Dose Ranging RCT (INSUPP-PCOS)
Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women in the U.S. and is characterized by both reproductive (anovulation and androgen excess) and metabolic dysfunction (insulin resistance). PCOS lacks a simple, safe and effective treatment for women of all ages and all weights. Recently
a dietary supplement, inositol, has been used widely to treat women with PCOS. However there are no well designed trials to address the risk/benefit ratio and identify the mechanism of action. In this study we propose a 3 month double blind (of both patients and investigators) randomized controlled trial of inositol supplementation compared to placebo. We hypothesis that women with PCOS who receive inositol supplementation will have a significantly greater reduction in serum total testosterone than women on placebo as well has improvement in glucose tolerance and decrease in fasting insulin.
Amyee McMonagle at amcmonagle@pennstatehealth.psu.edu or 717-531-4484
Female
18 year(s) or older
N/A
Women's Health
Management Of Pain After Cesarean Trial
This is a double blinded, placebo-controlled randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen and placebo on the patient's reported pain score on the second post-operative day after Cesarean delivery. We will also record opiate consumption and pain scores throughout the hospitalization of participants, and will survey patients at one and two weeks after surgery regarding opiate consumption and quality of life.
Avi Hameroff at ahameroff@pennstatehealth.psu.edu or 717-531-8142, ext=5
Female
All
NCT03929640
Pregnancy & Infertility, Women's Health
Site for Strong Foundations: Intervening to Promote Co-Parenting in Expectant Parents and Healthy Child Development.
Our goal is to examine the efficacy of Strong Family Foundations parenting classes in reducing couple conflict, promoting co-parenting quality, parental sensitivity, and child development outcomes within families. We hope to enroll 220 couples in our parenting program. Participants will participate in parenting classes before and after the birth of their child, and research assessments 6 and 12 months postpartum.
Jenna Sassaman at jnk5173@psu.edu or 814-865-6902
All
18 year(s) or older
NCT04441307
Children's Health, Pregnancy & Infertility, Women's Health
Precision AIM: Adaptive Text Message Intervention
This research is being done to determine if receiving interventional text messages can encourage physical activity levels. The type of message to be sent, along with the timing of the messages and consideration of weather will be explored for each person. The “mathematical formula” for each participant will be modified on a monthly basis throughout the six-month study to give participants the right message at the right time and weather conditions to encourage increased physical activity levels.
Deborah Reese at dlb43@psu.edu or 814-865-7935
All
18 year(s) or older
NCT04972279
Men's Health, Mental & Behavioral Health, Women's Health
Harnessing Artificial Intelligence to Improve Psychiatry
This study intends to improve detection of depression and anxiety by examining speech features recorded by a voice app and analyzing the voice data using cutting-edge artificial intelligence approaches. Eligible participants who are interested in this study will choose a few mentally stimulating topics to speak about to the voice app briefly, fill in some questionnaires, and complete a brief clinical interview. All of the procedures for this one-session study will last up to 90 minutes.
If you are interested in participating, please take a few minutes to complete the screening survey: https://pennstate.qualtrics.com/jfe/form/SV_8CHWpLRGUrvy49D
Irene Baik at sbb5887@psu.edu or 814-863-0115
All
18 year(s) or older
N/A
Men's Health, Mental & Behavioral Health, Women's Health
The effect of positive and negative self-talk on postural control and balance among college-aged adults
The project will aim to examine the role of self-talk or positive self-motivation on controlling body balance while performing specific balance tasks. Previous research has examined how self-talk can impact performance on sport-related movements (i.e. golf or tennis swings), but only a small portion of studies have examined how this strategy can improve balance. These studies have looked at specific populations, such as individuals with learning disabilities and individuals with limb amputations, so the question remains if the self-talk strategy can impact how generally healthy individuals control balance. Participants will test the self-talk strategies while performing tasks in natural environments. These tasks will be specifically designed to elicit postural responses. Therefore, the purpose of this study will be to examine the effects of positive and negative self-talk on balance performance in college-aged adults.
Fabricio Saucedo at Fns5045@psu.edu or 814-949-5703
All
18 year(s) or older
N/A
Men's Health, Sports Medicine, Women's Health
Heart Rate Variability in Orthostatic Hypertension
The study will examine a condition known as orthostatic hypertension, which is a sudden increase in blood pressure when a person stands up. Orthostatic hypertension is a recognized risk factor for cardiovascular diseases.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
N/A
Men's Health, Heart & Vascular, Women's Health
Women and Infants' Stress and Health
The goal of this study is to understand how babies and their mothers learn to respond to stress during the early years of the baby's life. Participating women complete questionnaires and do a mildly stressful task alone (during pregnancy) or with their babies (at four different times over the first two years of the baby's life) and collect saliva samples that tell us about stress responses, either at home or at one of our lab sites. We aim to use what we learn to better support expecting parents who may be at risk for stress-related health problems and improve their children's resilience to stress throughout life.
Sandra Rosario at PRISMlab@psu.edu or 814-867-6482
All
All
N/A
Pregnancy & Infertility, Mental & Behavioral Health, Women's Health
Randomized clinical trial of digital physical activity promotion interventions for young adults
The purpose of this voluntary research study is to determine the effects of different methods of promoting physical activity with wearable devices and technology.
Deborah Reese at dlb43@psu.edu or 814-865-7935
All
18 year(s) or older
NCT04972279
Men's Health, Mental & Behavioral Health, Women's Health
Penn State Exercising Women's Study
This study aims to assess energy status in young sedentary and exercising women as it is related to menstrual status, bone health, psychological health, sleep variables, and cardiovascular function.
Ana Carla Chierighini Salamunes at akc6247@psu.edu or 814-863-4488
Female
18 year(s) or older
N/A
Food & Nutrition, Muscle & Bone, Women's Health
Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes
The goal of this study is to learn more about how people who smoke
cigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 814-867-2333
All
18 year(s) or older
N/A
Men's Health, Addiction & Substance Abuse, Women's Health
Examining Maternal Reward Responsiveness and the Intergenerational Risk for Depression
Children of depressed mothers are at high risk for developing depression, particularly as youth age into adolescence, yet relatively little is known about the mechanism underlying risk for depression in youth with depressed mothers. The present study examines maternal reward responsiveness, measured across neurophysiological, behavioral, and self-report measures as a marker of depression in mothers of adolescents. Associations between maternal reward responsiveness and parenting difficulties often associated with maternal depression, as well as adolescent functioning will be examined, to explore the clinical impact of maternal reward responsiveness on the intergenerational transmission of depression.
Sarah Shahriar at sshahriar1@pennstatehealth.psu.edu or 717-531-0003, ext=285189
All
All
N/A
Children's Health, Mental & Behavioral Health, Women's Health
Postmenopausal women and their endothelium: Is dietary nitrate supplementation protective?
Heart disease is the leading cause of death in the United States. The loss of estrogen from menopause puts women at a greater risk of developing heart disease.
The purpose of this study is to determine the effects of drinking beetroot juice on measures of blood vessel health and blood pressure. Participants will drink beetroot juice and placebo juice each for one week followed by blood pressure measurements and ultrasound imaging of an artery in the upper arm.
A sub-aim of this study is to investigate the effects of estrogen status on blood vessel function between pre- and post-menopausal women.
Jocelyn Delgado at jmd956@psu.edu or 408-679-8390
Female
18 year(s) or older
NCT03644472
Food & Nutrition, Heart & Vascular, Women's Health
Centre County COVID-19 Data 4 Action Study
The purpose of this research is to evaluate the extent of COVID-19 risk and perceived risk among Centre County residents and students, and how those risks evolve from the time isolation guidelines were implemented through a return to normal functioning.
Participants in this research will complete an electronic survey with questions about their demographic, about their exposure to COVID-19, and about how COVID-19 has affected their health and work/education.
Data from this research will be used to inform Centre County planning authorities and the Pennsylvania State University about the needs of communities, including needs for information dissemination and for potentially actionable, local interventions in response to the COVID-19 pandemic.
Susan McHale at src-ssri@psu.edu
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Men's Health, Women's Health
Using Social Media to Perform Parasocial Relationships with Celebrities
This research is being conducted to create a better understanding of how parasocial relationships are developed by young adults with actors, artists/musicians, and fictional characters. This research aims to understand the extent of how Tumblr users interact and follow celebrities or fictional characters and the attachment they form to them. The participants will fill out an online survey asking questions about their emotional intensity and dedication to a celebrity or fictional character as well as whether you share about them and what technology they use. Participants may skip any questions that she/he would prefer not to answer.
Courtney Smith at ces92@psu.edu
All
18 year(s) or older
N/A
Men's Health, Education, Women's Health
A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain
We are looking to conduct a study looking at the effects of cannabidiol (CBD) in patients with endometriosis. We believe that CBD will improve both pain and quality of life.
The study will last a total of 12 weeks and involve several onsite visits in addition to daily pain assessments.
Barb Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
NCT04527003
Pain Management, Women's Health
Site for EMPOWER: Endometriosis diagnosis using MicroRNA: PrOspective study in Women to allow Early disease Recognition
This is a multi-center, observational study, the results of which will be used to support marketing for the intended use of the DotEndo investigational diagnostic. DotEndo is a non-invasive in vitro diagnostic test that measures levels of circulating miRNA biomarkers in whole blood. The DotEndo blood test will use a distinct classifier algorithm, based on levels of disease-specific miRNAs, to aid in the diagnosis of active endometriosis disease.
The study will enroll women 18 to 49 years old who have been referred to surgery for suspected endometriosis and other benign gynecological indications. Subjects will answer questionnaires and whole blood and saliva samples will be collected prior to and after surgery. Participation is expected to be approximately 3 months with some subjects continuing with annual follow-up post-surgery for 2 years.
Kaedryn DiGuglielmo at kdiguglielmo1@pennstatehealth.psu.edu or 717-531-1510
Female
18 year(s) or older
NCT04598698
Women's Health
Voice Perception Study
This is a voice perception study that asks participants to listen to voices and rate on various attributes such as attractiveness, social status, health, and others.
Toe Aung at txa96@psu.edu or 775-225-1747
All
18 year(s) or older
N/A
Men's Health, Women's Health
Optimizing Maternal Nutrition: Adaptive trials and molecular methods to improve maternal and newborn health
Poor maternal nutrition is linked to poor birth outcomes. Current vitamin and mineral recommendations in pregnancy are based on limited data mostly from animal models and non-pregnant people. This study seeks to improve our understanding of the amounts of vitamins and minerals that are needed during pregnancy, to improve the health of women and newborns, especially in low-and middle-income countries. Nutrients travel around the body in blood, therefore part of the research is to understand how much blood and the watery component of blood (plasma) increases in pregnancy. This is a collaborative study with George Washington University (lead PI is there). The Penn State team will conduct pilot work to establish a method for measuring plasma volume in 2 phases. In phase 1, nonpregnant will be asked to attend one visit and plasma volume will be measured by injecting indocyanine-green (ICG, a green dye) and hydroxyethyl starch (HES, a form of starch) through an IV in the arm. In phase 2, pregnant women will be asked to attend 2 visits that are 4 weeks apart, but only HES (the starch) will be injected. For both phases (1 and 2), blood draws will occur at each visit and other non-invasive measurements will also be taken (e.g. weight, height, blood pressure). Each visit should take less than 2 hours and will be conducted at the Clinical Research Center in Noll Laboratory on the Penn State campus.
Leigh Taylor at lam5935@psu.edu or 814-867-5938
Female
18 year(s) or older
N/A
Food & Nutrition, Pregnancy & Infertility, Women's Health