Search Results within category "Women's Health"
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Study matches:
28
The Sexual Relationships Study
The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following:
Aim 1. Examine the heterogeneity in relationship quality among female college students.
Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence?
Aim 2. Examine the association between relationship characteristics and latent class membership.
Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality?
Aim 3. Examine the association between latent classes of relationship quality and condom use.
Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex?
Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Jessica Salas-Brooks at jis5940@psu.edu or 7042494252
Female
18 year(s) or older
Show full eligibility criteria
N/A
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis
This study is for patients who have been diagnosed with moderate to severe ulcerative colitis (UC) who are experiencing bloody diarrhea, abdominal pain, and a sudden and constant feeling of needing to move their bowels. Additionally, patients have been unable to tolerate or have had an insufficient response to treatment with medications that help reduce inflammation associated with UC. This research is being done to evaluate the safety of different doses of ABT-494 (study medication) and determine how well it works, as well as how the study medication is absorbed, distributed and eliminated in the body over time.
Amy Behe at abehe@pennstatehealth.psu.edu or 814-689-0014
All
18 year(s) or older
Show full eligibility criteria
NCT02819635
Role of angiotensin II and inflammation in persistent vessel dysfunction following preeclampsia
The purpose of this study is to determine what contributes to blood vessel damage during and immediately following a preeclamptic pregnancy. To do this, we examine blood vessel function in the small vessels in the skin. Understanding what contributes to these impairments may lead to better treatments and/or prevention strategies for vessel dysfunction in women who have or had preeclampsia.
Two groups of subjects will be enrolled in this study: women who have delivered within 1 year and who have had a preeclamptic pregnancy diagnosed by their obstetrician, and women who have delivered within 1 year and did not have preeclampsia.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
Show full eligibility criteria
NCT03482440
Cyclic Variation in Micronutrient Concentrations and Plasma Volume in Reproductive-Age Women
In this study, we will examine how the menstrual cycle influences micronutrient concentrations in women of reproductive age. We will also examine how the menstrual cycle affects plasma volume in these women. Finally, we will assess the relationship between plasma volume and micronutrient concentrations among study participants. This study involves three visits to the Clinical Research Center (CRC) located in Noll lab, University Park. To participate, interested women will contact the study coordinator via phone or email and provide their name and phone number.
A member from the PI lab will contact the interested participant to screen her for eligibility. If a participant is eligible, she will be scheduled to visit the CRC, where eligibility will be confirmed. To confirm eligibility, we will measure her weight, height, blood pressure and conduct a pregnancy test. If eligible, we will conduct hydration test, and measure body composition, then she will complete a short questionnaire about her pregnancy histories and health. She will then rest on bed for 15 to 20 minutes and the nurse will insert an IV to draw some blood ~15mL. Then the nurse will inject her with a small amount of a green dye followed by a series of blood draws (total ~15mL) within the next 5 minutes.
She will relax on the bed or sit on a chair for 15 minutes to be monitored by the nurse, to be sure that she is okay. Then we will provide her with a home-based fertility monitor to be used to track her menstrual cycle. We will instruct her on how to use her urine sample to track daily changes in some targeted reproductive hormones during the cycle. The results are displayed in a simple to read format from the monitor. We will use the readings from this monitor to schedule visit 2 (~ day 12 of her cycle). After visit 2, the participant will conduct a few more urine test at home and the results of those tests will be used to schedule her final last visit (~ day 21 of her cycle). On the 2nd and 3rd visits, we will again measure her weight, height, blood pressure and conduct pregnancy to confirm that the participant is still eligible. If we confirm she is still eligible, we will complete the rest of the measurements as in visit one. Blood samples at each visit will be processed and stored at -80C until the data collection is completed. Plasma samples will be processed same day to determine the subject’s plasma volume.
Sixtus Aguree at sua204@psu.edu or 814-867-5938
Female
18 year(s) or older
Show full eligibility criteria
NCT03422809
A Phase 3, Multicentre, randomized, double-blind, placebo-controlled study investigating the efficacy and safety of daily oral administration of OBE2109 alone and in combination with add-back therapy for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.
To evaluate the safety and efficacy of OBE2109 alone and in combination with add-back therapy versus placebo on reduction of heavy menstrual bleeding, hemoglobin levels, pain, fibroid symptom severity, and health related quality of life in pre-menopausal women with uterine fibroids.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
Show full eligibility criteria
NCT03070899
Gestational transmission of HPV from mother to fetus
HPV infections induce changes in the female genital tract, apoptosis in embryonic cells, and miscarriages or premature rupture of the membranes. Importantly, pregnant women are more susceptible to HPV infections due to the relative immunosuppression experienced during pregnancy. HPV-induced Recurrent Respiratory Papillomatosis (RRP) is believed to result from HPV transmission from mothers to newborns as a result of passage through the birth canal. RRP is a highly morbid pathological condition among children. It is characterized by the recurrent appearance of wart-like lesions in the respiratory tract, particularly at the larynx and vocal cords. These patients must undergo repeated surgery or other invasive treatment to manage the disease. Whether HPV infections play a role in infertility and childhood RRP in the Central Pennsylvania is unknown.
Heidi Reinhard at hreinhard@pennstatehealth.psu.edu or 717-531-5166
Female
18 year(s) or older
Show full eligibility criteria
N/A
Lunch Feeding Study for Men and Women
Investigating the relationship between portion size and satiety.
Alyssa Spaw at ads27@psu.edu or 814-863-8482
All
18 year(s) or older
Show full eligibility criteria
NCT03409601
Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis
Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women.
Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
Show full eligibility criteria
N/A
AWS-PSU: Active Women's Study at Penn State University and AWS-Lincoln: Active Women’s Study Lincoln University
AWS-PSU: Active Women's Study at Penn State University and Lincoln University
This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Emily Southmayd at eas5377@psu.edu or 814-863-4488
Female
18 year(s) or older
Show full eligibility criteria
N/A
Improving Reproductive Fitness with Pretreatment with Lifestyle Modification in Obese Women with Unexplained Infertility: FIT-PLESE
This research is being done to find out the effects of lifestyle modification in obese women with unexplained infertility. Phase 1 of the study is 16 weeks and includes two types of lifestyle modifications: 1) increased physical activity by increasing steps per day OR 2) a calorie restricted diet using meal replacements and a weight loss medication called Orlistat (Alli) with increased physical activity. After completion of Phase 1 lifestyle modification, the subject will move to Phase 2 which involves 3 cycles of infertility treatment involving ovarian stimulation with an oral medication (Clomiphene Citrate) followed by triggered ovulation using hCG injections and single intrauterine insemination.
Patsy Rawa at prawa@pennstatehealth.psu.edu or 7175313692
Female
18 year(s) or older
Show full eligibility criteria
N/A
E-cigarette Use among College-Age Individuals in Association with Biomarkers of Bone Health
Vitamin D and cigarette use are well-known to influence bone health. However, we know little about whether e-cigarettes may also play a role. We invite you to help us learn more about whether e-cigarette use may influence vitamin D levels and/or bone health. Participation requires one in-person visit (approximately 20 minutes in length) and questionnaire completion (approximately 40 minutes in length).
Cyndi Flanagan at chf117@psu.edu or 814-863-7126
Female
18 year(s) or older
Show full eligibility criteria
N/A
A Phase 3b Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Combination with Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated with Uterine Fibroids in Premenopausal Women
The objectives of this study are to assess the long term efficacy and safety of elagolix alone and elagolix in combination with add back therapy to reduce heavy menstrual bleeding associated with uterine fibroids and characterize the impact on bone density after up to 2 years of treatment.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
Show full eligibility criteria
NCT03271489
Randomized Feasibility Study of Patient Navigation for Women Identified with Dense Breast Tissue on a Breast Cancer Screening Mammogram - AWARE
This research is being done to find whether a telephone-based navigation improves knowledge, attitude, and behaviors related to dense breast tissue, and if the navigation changes the rate at which the women receive supplemental breast cancer screening, compared to usual care. Approximately 60 women between 40 and 74 years of age with dense breasts will take part in this research study across central Pennsylvania. Participants will be completing surveys by phone up to four times over the 12-week study.
Sol Rodriguez-Colon at srodriguez@psu.edu or 717-531-5190
Female
18 year(s) or older
Show full eligibility criteria
N/A
Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women
This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
Show full eligibility criteria
NCT02822378
Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes
The goal of this study is to learn more about how people who smoke
cigarettes respond to rewards, such as winning money, under different
conditions. The study uses a method called functional magnetic
resonance imaging, or fMRI, which is a research method for measuring
activity in the brain. In this study, we are using fMRI to measure how
brain activity changes in people who smoke when they receive rewards.
The fMRI measures are collected during two separate visits.
Participants are also asked to fill out questionnaires and complete
computer tasks while in the lab. In total, participants are required
to visit the research lab on the University Park campus a total of
five times. In addition, the study involves measuring thoughts and
behaviors in people who smoke in real life by asking them to fill out
surveys on a smartphone. Participants are asked to carry a smartphone
for a total of 10 days and answer several surveys throughout each day.
In order to be eligible for the study, individuals must be between 18
and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 8148672333
All
18 year(s) or older
Show full eligibility criteria
N/A
Evaluation of Vitamin D With And Without Hormonal Contraception on Sexual Function in Women With Polycystic Ovary Syndrome
To evaluate the prevalence of sexual dysfunction (SDy) in women with Polycystic Ovarian Syndrome (PCOS) and to determine the effects of Vitamin D therapy, with and without hormonal contraceptives, on SDy in women with PCOS in the absence of depression.
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
Show full eligibility criteria
NCT02865187
Evaluation, Validation and Refinement of Noninvasive Diagnostic Biomarkers for Endometriosis
The lining of the uterus is called the endometrium. This is the tissue in which a fertilized egg implants to grow into a baby; it is also shed each month during a woman’s period. Endometriosis is a disease in which this tissue grows in other places in the body, most often in the lining of the abdomen or pelvis, or on the ovaries. This abnormal tissue growth can cause pelvic pain and infertility. The only way that doctors can tell for sure if a woman has endometriosis is to perform surgery and look for this abnormal tissue.
The purpose of this study is to see if substances found in blood or the lining of the uterus can predict whether women do or do not have endometriosis, and how severe their condition is. To do this, doctors need to study both women who have endometriosis and those who do not. About half of the women in this study will be having surgery for suspected endometriosis. The rest will be having surgery for other reasons, such as having their tubes tied, or to remove benign growths from the uterus.
These scheduled surgeries will allow the physicians to see whether or not endometriosis is present, and if so, how severe it is. We will collect a sample of the uterine lining, and blood and urine samples, and will study these samples to see if they can give us information about whether or not women have endometriosis, with the hope that this information could be used in the future to diagnose this condition instead of requiring surgery.
Patsy Rawa at prawa@pennstatehealth.psu.edu or 7175313692
Female
18 year(s) or older
Show full eligibility criteria
N/A
SPIRIT 1: An International Phase 3 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study to Evaluate Relugolix Administered with and without Low-Dose Estradiol and Norethindrone Acetate in Women with Endometriosis-Associated Pain
Endometriosis is a common chronic condition that can cause pain in the lower part of the stomach (pelvis) during the menstrual period and at other times and pain during sexual intercourse.
The purpose of this study is to test how effective and safe the investigational study drug, relugolix (rel-U-GO-lix), given with or without low-dose estradiol and norethindrone is in treating endometriosis-associated pain. Estradiol is a form of estrogen and norethindrone is form of progesterone. Both estrogen and progesterone are hormones normally made by women’s bodies. These hormones help control the menstrual cycle and menstrual periods and also support bone health. The study wants to know if endometriosis pain affects how women function, how they feel and if the study drug is effective and safe at treating the pain from endometriosis.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
Show full eligibility criteria
NCT03204318
Feasibility Study Phase C: Expansion in Multiple Institutions for Training in the Use of the LUM Imaging System for Intraoperative Detection of Residual Cancer in the Tumor Bed of Female Subjects with Breast Cancer
The main goal of standardizing the training for surgeons and clinical staff that will be participating in the anticipated pivotal study of the Lumicell Imaging System.
Identify and address any site-specific or user-specific issues for using the LUM Imaging System in breast cancer patients and to collect safety and efficacy data.
Stephanie Gorrell at sgorrell@pennstatehealth.psu.edu or 717-531-0003, x286789
Female
18 year(s) or older
Show full eligibility criteria
NCT02438358
Long-Term Nicotine Treatment of Mild Cognitive Impairment
The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in people experiencing mild memory problems (referred to in this study as “mild cognitive impairment” or MCI).
Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain. This chemical substance, acetylcholine, is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our In people with MCI (and Alzheimer’s disease), the level of acetylcholine may be changed, and this may impair brain functioning. Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimer’s disease (AD). It has been known for many years that nicotine imitates many of the actions of acetylcholine.
By administering nicotine over a longer period of time to participants with MCI, we hope to better understand whether nicotine may act to improve memory loss symptoms over the longer term and whether it may help to delay the progression of memory loss symptoms.
The amount of nicotine in each patch used in this study is the same as patches that are used in people who are trying to quit smoking.
All
18 year(s) or older
Show full eligibility criteria
NCT02720445
Non-pharmacological improvement of sleep structure in older people
Wrist actigraphy has emerged as a popular alternative to polysomnography because of its low level of invasiveness, its manageable cost, and its ease of monitoring sleep-wake cycles. Unfortunately, actigraphy is not useful for measuring sleep quality in aging populations with fragmented and abnormal sleep patterns because of the very low specificity of actigraphy to detect quiet wake. This application proposes to develop and test a new algorithm that will use actigraphy, photoplethysmography and sensory stimulation during sleep to improve detection of sleep stage in midlife and older adults. The main goals of this project are to conduct a proof-of-principal study in a group of midlife volunteers to demonstrate the superiority of the new method to other non-polysomnography based methods of determining sleep stages, and to attempt to improve the sleep quality of mid-life and older adults by systematically playing sounds during sleep.
Margeaux Gray at deepsleep@psu.edu
All
18 year(s) or older
Show full eligibility criteria
N/A
Reward function as a mechanism linking personality and intermittent smoking
The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. The study requires one visit to the lab that lasts approximately three hours. In order to be eligible for the study, individuals must be between 18 and 25 years and must smoke on some (but not all) days.
Melinda Ashe at mla233@psu.edu or (814) 867-2333
All
18 year(s) or older
Show full eligibility criteria
N/A
The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.
The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.
The aims of the PRIDE Program are to:
1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure.
2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants.
3. Establish a mechanism for approving use of the banked biospecimens for future research.
Syndi Reed at creed@pennstatehealth.psu.edu or 855-369-3540
All
All
Show full eligibility criteria
N/A
The Effect of a Mixed-Composition Meal on Thermic Effect of Food, Fuel Utilization, Subjective Appetite, and Appetite Hormone Responses in Young Exercising Women across the Body Mass Index Spectrum
The Women’s Health and Exercise Laboratory is seeking research participants for a study investigating the metabolic, hormonal, and psychological effects of a meal in women. In addition to being monetarily compensated, participants will receive an analysis of their diet, hormone levels, metabolism, and body composition.
Participants should be:
Female, healthy 18-35 year old, non-smoking, with a BMI between 16-35 kg/m2, have not had a menstrual period in the last 3 months, and not taking hormonal contraceptives.
OR
Female, healthy, 18-35 year old, moderately overweight (BMI 25-35 kg/m2), non-smoking, regular menstrual cycles for the past 6 months and are not taking hormonal contraceptives.
This study is under the direction of Drs. Nancy Williams and Mary Jane De Souza (Department of Kinesiology) and requires regular visits (4-5 visits) to Noll Laboratory on the University Park campus over approximately 2 months. For more information please call (814) 863-4488, or email WHEL@psu.edu
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
Show full eligibility criteria
N/A
Young Adults Dating Online with a Disability
The purpose of this qualitative study is to learn about the online dating experiences of 25 young adults (ages 18-30) in the US using surveys.
Elizabeth Mazur at emazur@psu.edu or 4126759186
All
18 year(s) or older
Show full eligibility criteria
N/A
The COMET-PCOS trial- Comparing the effects of Oral Contraceptive Pills versus Metformin in the medical management of overweight/obese women with Polycystic Ovary Syndrome
To determine the effect of Oral Contraceptive Pills (OCP) verses Metformin verses OCP and Metformin on the prevalence of Metabolic Syndrome (MetS) and its components in overweight/obese women with Polycystic Ovary Syndrome (PCOS).
Patsy Rawa at prawa@pennstatehealth.psu.edu or 7175313692
Female
18 year(s) or older
Show full eligibility criteria
NCT03229057
Standardization and normative data of the symbol digit modalities test (SDMT) - oral version
The symbol digit modalities test (SDMT) is a paper test given to people to see how quickly they process information. The purpose of this research study is establish updated accurate data on healthy individuals to use as a comparison for cognitive (thinking) impairment associated with Multiple Sclerosis (MS). Study is currently looking for individuals age 25-74 with less than four years of college education.
Erin Guty at exg5204@psu.edu or 814-865-5578
All
18 year(s) or older
Show full eligibility criteria
N/A
A Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Combination with E2/NETA in Subjects with Moderate to Severe Endometriosis Related Pain
A Phase 3 24 month study to evaluate the safety and efficacy of elagolix in combination with add back therapy in the management of of endometriosis associated pain in premenopausal women
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
Show full eligibility criteria
NCT03213457