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Suggestions within category "Lung Disease & Asthma"


Study matches: 11

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


A Phase I/II, Multi-Center, Randomized, Placebo-Controlled, Study Designed to Assess the Safety, Tolerability, and Pharmacokinetics of PTI-428 in Subjects with Cystic Fibrosis

This is an investigational drug study that will examine the safety, tolerability and PK in multiply cohorts within subjects with Cystic Fibrosis.
Diane Kitch at dkitch@pennstatehealth.psu.edu or 7175315646
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Must have Cystic Fibrosis
FEV1 predicted values between 40-90%
non-smoker and non-tobacco
BMI >17kg/m2
Stable on Orkambi, or Orkambi Naiive
Exclusion Criteria:
Liver enzymes greater than 3X upper limit of normal
Recent hospitalization within 1 month of Day 1 visit
History of alcohol/drug abuse in the past 12 months
+ testing for HIV, Hepatitis B or Hepatitis C
Participation in another clinical trial within 30 days from Day 1
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NCT02718495
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Hershey, PA

Randomized Controlled Trial Methods for Novel Tobacco Products Evaluation

This study will start a systematic evaluation of a novel and increasingly popular tobacco product, electronic cigarettes (ECIG). Despite their popularity, little robust evidence is available regarding ECIG safety or effectiveness. Instead, assertions are made that ECIGSs likely will reduce tobacco toxicant exposure, probably produce no adverse events, and therefore may lessen the risk of tobacco-caused disease by reducing cigarette use. In fact, the data addressing how long-term ECIG use influences toxicant exposure, user health, and concurrent cigarettes smoking are very limited. However, each of these issues can be addresses empirically using an RCT. This project’s goal is to demonstrate how RCT methods can be used to evaluate MRTPs generally and ECIGs particularly.
Robinn Moyer at rmoyer3@pennstatehealth.psu.edu or 717-531-4176
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Age 21-65
Smoke >9 cigarettes per day for at least 1 year
Interested in reducing cigarette consumption
Exclusion Criteria:
Pregnant and/or nursing women
Use of any non-cigarette nicotine delivery product (pipe, cigar, dip, chew, snus, hookah, ECIGs, strips, sticks) in the past 7 days
Known allergy to propylene glycol/vegetable glycerin
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NCT02342795
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Hershey, PA

Pulmonary Fibrosis Foundation Patient Registry and Biorepository

The aim of the registry is to create a cohort of well-characterized patients with interstitial lung disease (ILD) for participation in retrospective and prospective research.
Timothy Sheehan at tsheehan@pennstatehealth.psu.edu or 7175312925
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
18 years old or older
Able to understand and sign informed consent document
Diagnosis of Interstitial Lung Disease
Anticipated appointment to Penn State Hershey Medical Center Pulmonary Clinic
Exclusion Criteria:
Diagnosed with Sarcoidosis
Diagnosed with Lymphangioleiomyomatosis (LAM)
Diagnosed with Pulmonary alveolar proteinosis (PAP)
Diagnosed with Cystic fibrosis (CF)
Diagnosed with Amyloidosis
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NCT02758808
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Hershey, PA

INtervention Study In overweiGHT patients with COPD (INSIGHT COPD)

This study is testing the effectiveness of an evidence based, self-directed, lifestyle intervention for 12 months targeting modest weight loss and increased physical activity among overweight and obese patients with COPD. Randomized study to usual care vs usual care plus the self-directed program.
Timothy Sheehan at tsheehan@pennstatehealth.psu.edu or 7175312925
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
40 years of age or older
Diagnosis of COPD
Body mass index (BMI) between 25.0-44.9
Smoked at least 10 pack-years of cigarettes
Access to DVD player or internet
Exclusion Criteria:
Active participation/use of weight loss interventions
Expected weight loss because of alternate explanations (i.e. illness)
Unable to walk to weight scale
Participation in other intervention studies
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NCT02634268
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Hershey, PA

Evaluating the Cough Reflex in Fibrotic and Healthy Lungs

Determining cough threshold in patients with fibrotic lung disease and in healthy controls by stimulating cough.
Timothy Sheehan at tsheehan@pennstatehealth.psu.edu or 7175312925
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
40 years of age or older
Patient Group: Fibrotic lung disease with chronic cough symptoms or Idiopathic cough syndrome
Healthy Control Group: no cough (either chronic or acute)
Exclusion Criteria:
Recent history of smoking (former smokers must be tobacco-free for at least 1 year)
History of (other) lung diseases
History of uncontrolled gastroesophageal reflux disease (GERD)
Use of exclusionary medications (i.e. steroids, ACE inhibitors, narcotics, cough suppressants)
History of uncontrolled post nasal drip
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N/A
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Location
Hershey, PA

A Phase 3, Randomized, Open-Label, Assessor-Blind, Non-Inferiority, Active-Comparator Study Evaluating the Efficacy and Safety of Liprotamase in Subjects with Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency

This is a study comparing pancreaze, an approved pancreatic enzyme used to treat pancreatic insufficiency in patients who have cystic fibrosis, to a new study drug enzyme that's in a liquid formulation and is not derived from pig pancreas.
Diane Kitch at dkitch@pennstatehealth.psu.edu or 717-531-5646
All
Not specified
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Must have Cystic Fibrosis and Pancreatic Insufficiency
Must be taking same dose of enzymes for the past 30 days
Have stable nutritional status
Be able to swallow capsules
Exclusion Criteria:
Not taking Pancreaze as an enzyme
Unstable liver or kidney tests
May not have a G-tube
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N/A
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Hershey, PA

SAV005-04 "A Phase III, randomized, double-blind, placebo-controlled study of AeroVanc for the treatment of persistent methicillin-resistant Staphylococcus aureus lung infection in cystic fibrosis patients

This is a study that will examine any benefits to use cycles of inhaled vancomycin compared to placebo. Analysis of the information will include lung function results, sputum or throat culture results, questionnaires, and time to use additional antibiotics up to 48 weeks. After the first 24 weeks, all subjects can receive open label study drug for the remaining 24 weeks. There are 13 study visits spanned over 48 weeks.
Diane Kitch at dkitch@pennstatehealth.psu.edu or 7175315646
All
Not specified
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
6 years old and greater
Must have Cystic Fibrosis (CF)
Positive culture for MRSA at screening
FEV1 between 30-90%
Commit to 14 visits over 12 months
Exclusion Criteria:
You may not have allergies to vancomycin
Abnormal liver or kidney function
Inability to tolerate inhaled products
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NCT03181932
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Hershey, PA

Establishing a Normal Database for Comparison to Specialized Populations; Pulmonary Function Tests

This study will evaluate lung function by measuring volumes, flow, capacity and other variables by completing various breathing tests into a machine. This will contribute to a database of healthy adults to compare to persons with disabilities.
Kristin Slavoski at PMR_Research@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy Adults
Age 18-75
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Pregnancy
High Blood Pressure
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N/A
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Hershey, PA

A Randomized, Placebo-Controlled, Double-Blind, Six Months Study Followed by an Open-Label -Extension Phase to Evaluate the Efficacy, Safety and Tolerability of MN-001 in Subjects with Idiopathic Pulmonary Fibrosis (IPF)

The purpose of this research study is to evaluate the effectiveness and safety of MN-001(tipelukast) in subjects with IPF.
Kim Hitz at khitz1@pennstatehealth.psu.edu or 7175667765
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
diagnosis of pulmonary fibrosis
presence of stage I-III defined by GAP index
Exclusion Criteria:
expected to receive a lung transplant in the next 12 months
known explanation for interstitial lung disease
ongoing treatment with Esbriet
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NCT02503657
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Hershey, PA

A double-blind, randomized, placebo-controlled trial evaluating the efficacy and safety of nintedanib over 52 weeks in patients with progressive fibrosing interstitial lung disease (PF-ILD)

This study is for patients who have progressive fibrosing interstitial lung disease (PF-ILD) to see how well an investigational medicine called nintedanib, may help this lung disease. The study will also compare the safety and effects of the investigational medicine with a placebo (a pill without medication).
Anne Dimmock at adimmock@pennstatehealth.psu.edu or 717-531-2925
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Patients diagnosed with pulmonary fibrosis interstitial lung disease
Exclusion Criteria:
Patients with underlying chronic liver disease
Previous treatment with nintedanib or pirfenidone
Significant pulmonary arterial high blood pressure
High Blood Pressure, Heart Attack or Unstable Chest pain within the past 6 months
Have an increased risk of bleeding
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NCT02999178
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Hershey, PA

Study of Clinical Efficacy of Antimicrobial Therapy Strategy Using Pragmatic Design in Idiopathic Pulmonary Fibrosis

This study is for patients with Idiopathic Pulmonary Fibrosis (IPF) to compare the effect of standard care versus standard care plus antibiotic therapy (co-trimoxazole or doxycycline) on reducing harmful infections that could lead to hospital visits or death in patients diagnosed with IPF.
Tim Sheehan at tsheehan@pennstatehealth.psu.edu or 717-531-2925
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Must be 40 years of age or older
Diagnosed with Idiopathic Pulmonary Fibrosis
Exclusion Criteria:
Received antimicrobial therapy in the past 30 days
Allergy or intolerance to tetracycline
Concomitant immunosuppression with azathioprine, mycophenolate, cyclophosphamide or cyclosporine
Received treatment with an investigational medication in the past 30 days
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NCT02759120
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Location
Hershey, PA