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Study matches: 10

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

This study is for patients who have been diagnosed with moderate to severe ulcerative colitis (UC) who are experiencing bloody diarrhea, abdominal pain, and a sudden and constant feeling of needing to move their bowels. Additionally, patients have been unable to tolerate or have had an insufficient response to treatment with medications that help reduce inflammation associated with UC. This research is being done to evaluate the safety of different doses of ABT-494 (study medication) and determine how well it works, as well as how the study medication is absorbed, distributed and eliminated in the body over time.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of ulcerative colitis for at least 90 days
Demonstrated an inadequate response to, loss of response to, or intolerance to steroids, immunosuppressants and/or biologic therapies
Exclusion Criteria:
Have a current diagnosis of Crohn's disease, fulminant colitis and/or toxic megacolon
History of total colectomy or ileostomy
Taking a probiotic and has not been on a stable dose for at least 10 days
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NCT02819635
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Location
State College, PA

Lunch Feeding Study for Men and Women

Investigating the relationship between portion size and satiety.
Alyssa Spaw at ads27@psu.edu or 814-863-8482
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
18
•60 years old
BMI between 18 -35
Exclusion Criteria:
<18 years old, > 60 years old
BMI <18 and/or >35
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NCT03409601
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Location
State College, PA

Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In total, participants are required to visit the research lab on the University Park campus a total of five times. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 8148672333
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
18-55 years of age
Right Handed
Smokes cigarettes
Exclusion Criteria:
under 18 years of age or over 55 years of age
Left Handed
non-smokers
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N/A
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Location
Altoona, PA
State College, PA

Long-Term Nicotine Treatment of Mild Cognitive Impairment

The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in people experiencing mild memory problems (referred to in this study as “mild cognitive impairment” or MCI). Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain. This chemical substance, acetylcholine, is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our In people with MCI (and Alzheimer’s disease), the level of acetylcholine may be changed, and this may impair brain functioning. Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimer’s disease (AD). It has been known for many years that nicotine imitates many of the actions of acetylcholine. By administering nicotine over a longer period of time to participants with MCI, we hope to better understand whether nicotine may act to improve memory loss symptoms over the longer term and whether it may help to delay the progression of memory loss symptoms. The amount of nicotine in each patch used in this study is the same as patches that are used in people who are trying to quit smoking.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Patient must have a subjective memory concern as reported by patient, study partner, or clinician
Age 55-90 (inclusive)
Study Partner is available who has frequent contact with the patient (e.g. an average of 10 hours per week or more), and can accompany the patient to most visits to answer questions about the patient
Must speak English fluently
Good general health with no additional diseases/disorders expected to interfere with the study
Exclusion Criteria:
Any use of tobacco or nicotine products within the past year
Any significant neurologic disease such as Alzheimer’s disease dementia, Parkinson’s disease, multi-infarct dementia, brain tumor, seizure disorder, etc.
History of alcohol or substance abuse or dependence within the past 2 years
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NCT02720445
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Location
Hershey, PA

Non-pharmacological improvement of sleep structure in older people

Wrist actigraphy has emerged as a popular alternative to polysomnography because of its low level of invasiveness, its manageable cost, and its ease of monitoring sleep-wake cycles. Unfortunately, actigraphy is not useful for measuring sleep quality in aging populations with fragmented and abnormal sleep patterns because of the very low specificity of actigraphy to detect quiet wake. This application proposes to develop and test a new algorithm that will use actigraphy, photoplethysmography and sensory stimulation during sleep to improve detection of sleep stage in midlife and older adults. The main goals of this project are to conduct a proof-of-principal study in a group of midlife volunteers to demonstrate the superiority of the new method to other non-polysomnography based methods of determining sleep stages, and to attempt to improve the sleep quality of mid-life and older adults by systematically playing sounds during sleep.
Margeaux Gray at deepsleep@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy adult not using sleep or circadian-impacting medications
No unmanaged chronic or acute illness
Aged 45-60 yrs
Non-smoker
Capable of providing your own informed consent
Exclusion Criteria:
Smoker or tobacco or nicotine user
Not able to abstain from caffeine, alcohol, or certain drugs/medications during the study
Severe, restrictive food allergies
Hearing or color vision problems
Typical sleep time >=9hrs per night
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N/A
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Study Locations

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Location
State College, PA

Reward function as a mechanism linking personality and intermittent smoking

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. The study requires one visit to the lab that lasts approximately three hours. In order to be eligible for the study, individuals must be between 18 and 25 years and must smoke on some (but not all) days.
Melinda Ashe at mla233@psu.edu or (814) 867-2333
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
18-25 years of age
Right handed
Native English speaker
Smoke cigarettes on some (but not all) days
Exclusion Criteria:
Attempting to quit smoking
Serious cardiovascular or respiratory disease
MRI conraindications
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N/A
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Location
Altoona, PA
State College, PA

The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.

The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program. The aims of the PRIDE Program are to: 1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure. 2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants. 3. Establish a mechanism for approving use of the banked biospecimens for future research.
Syndi Reed at creed@pennstatehealth.psu.edu or 855-369-3540
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
Any age
Ability of patient, child and/or parent to understand or complete the consent process
Exclusion Criteria:
Unable to understand or complete the consent process
Opted out of research studies
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N/A
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Study Locations

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Location
Hershey, PA

Males, Antioxidants, and Infertility (MOXI) Trial

The purpose of this research study is to learn if taking antioxidants can improve male fertility. Male infertility can be caused by DNA damage in sperm. The DNA damage affects the sperm's ability to move or fuse with the egg. Earlier studies have shown that taking antioxidants might improve this DNA damage. While we know this, we don't know if taking antioxidants can help couples get pregnant. This study will try to determine if taking antioxidants can help infertile couples achieve pregnancy.
Patsy Rawa at prawa@pennstatehealth.psu.edu or 7174688579
Male
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Are you >= 18 years old
Female between the ages 18
•40 with regular menstrual periods
Males with at least on abnormal semen measure within the past 6 months
Couples seeking pregnancy
Exclusion Criteria:
Previous sterilization procedures (vasectomy, tubal ligation)
Planning in vitro fertilization in the next 6 months
Female BMI > 35
Female with history of polycystic ovary syndrome
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N/A
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Location
Hershey, PA

Young Adults Dating Online with a Disability

The purpose of this qualitative study is to learn about the online dating experiences of 25 young adults (ages 18-30) in the US using surveys.
Elizabeth Mazur at emazur@psu.edu or 4126759186
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Between ages 18-30
Have a physical, sensory, emotional, and/or cognitive disability or impairment
) Have tried an online dating app or website at least once (such as, but not limited to, Tinder, Bumble, Zoosk, Grindr, Glimmer, Match.com, Dating4disabled, etc.).
Exclusion Criteria:
Younger than 18 or older than 30
Lack of a physical, sensory, emotional, and/or cognitive disability or impairment
Have never tried online dating
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N/A
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Standardization and normative data of the symbol digit modalities test (SDMT) - oral version

The symbol digit modalities test (SDMT) is a paper test given to people to see how quickly they process information. The purpose of this research study is establish updated accurate data on healthy individuals to use as a comparison for cognitive (thinking) impairment associated with Multiple Sclerosis (MS). Study is currently looking for individuals age 25-74 with less than four years of college education.
Erin Guty at exg5204@psu.edu or 814-865-5578
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between ages of 25-74
Less than 4 years of college education
Less than Bachelor's Degree
Medically Healthy
Exclusion Criteria:
Significant mental health disorder (e.g. bipolar, psychosis)
Diagnosed learning disability or ADHD
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N/A
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Study Locations

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Location
Altoona, PA
State College, PA