Refine your search

Search Results within category "Pregnancy & Infertility"

Search all categories
Study matches: 3

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Role of angiotensin II and inflammation in persistent vessel dysfunction following preeclampsia

The purpose of this study is to determine what contributes to blood vessel damage during and immediately following a preeclamptic pregnancy. To do this, we examine blood vessel function in the small vessels in the skin. Understanding what contributes to these impairments may lead to better treatments and/or prevention strategies for vessel dysfunction in women who have or had preeclampsia. Two groups of subjects will be enrolled in this study: women who have delivered within 1 year and who have had a preeclamptic pregnancy diagnosed by their obstetrician, and women who have delivered within 1 year and did not have preeclampsia.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
had a baby in the last 12 months
had preeclampsia or did not have preeclampsia
Exclusion Criteria:
had gestational diabetes
history of hypertension prior to pregnancy
current tobacco use
currently pregnant
currently taking medication to lower cholesterol
Show full eligibility criteria
NCT03482440
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Gestational transmission of HPV from mother to fetus

HPV infections induce changes in the female genital tract, apoptosis in embryonic cells, and miscarriages or premature rupture of the membranes. Importantly, pregnant women are more susceptible to HPV infections due to the relative immunosuppression experienced during pregnancy. HPV-induced Recurrent Respiratory Papillomatosis (RRP) is believed to result from HPV transmission from mothers to newborns as a result of passage through the birth canal. RRP is a highly morbid pathological condition among children. It is characterized by the recurrent appearance of wart-like lesions in the respiratory tract, particularly at the larynx and vocal cords. These patients must undergo repeated surgery or other invasive treatment to manage the disease. Whether HPV infections play a role in infertility and childhood RRP in the Central Pennsylvania is unknown.
Heidi Reinhard at hreinhard@pennstatehealth.psu.edu or 717-531-5166
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Pregnant
Exclusion Criteria:
Not pregnant
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team

Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis

Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women. Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
• Women, Ages 18-45
• Do or do not have endometriosis
• Have normal blood pressure
Exclusion Criteria:
• Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
• High Blood Pressure
• Abnormal liver function
• Known allergy statins (Lipitor)
• Pregnant or Breastfeeding
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA