For the current study, nicotine users will use an electronic cigarette in addition to their usual nicotine source for 4 weeks. The electronic cigarette will contain sweet or tobacco flavored liquid that may or may not contain nicotine. Participants will complete functional magnetic resonance imaging scans at the beginning and end of the study to measure how the brain responds to the electronic cigarette flavor.

There will be two remote visits and two in person visits. There will be a MRI during each in person visit and the subject will be given an study electronic cigarette to use between the two MRI visits.

220

This study is examining how the brain changes as people remain abstinent from smoking cigarettes over the course of approximately 1 year. We are using magnetic resonance imaging (MRI) to investigate how the brain's structure and function change over time in individuals who have recently quit smoking.

Participants will complete five in-person visits over the course of 9 months and 2 follow-up phone interviews at 12 and 15 months after the initial visit. Visits will include blood draws and MRI scans, completion of questionnaires about drug use and emotions, tests of memory and decision making, and urine drug tests. Telephone follow-ups will include questions about nicotine use.

590

Tobacco users will be randomized to use electronic cigarettes containing varying levels of nicotine and flavor during laboratory protocols to investigate the effects on the brain and behavior. Subjects will complete surveys, functional magnetic resonance imaging scans, and complete computerized tasks. Eligible participants include daily users of inhaled tobacco products who are at least 21 years old, able to read and write in English, and not planning to quit tobacco use within the next month. Exclusion criteria include: current substance use impairing participation, unstable or significant medical conditions, current use of smoking cessation medication, uncontrolled serious mental illness, and MRI safety or neurological contraindications.

Subjects will taste test a variety of e-cigarette flavorings, answer questions and complete a single MRI.

50

This research is being done to compare the differences in traditional cigarette reduction between smokers who receive a 0 mg/ml nicotine e-cig and those who receive a 58 mg/ml nicotine e-cig. We will also compare differences between the groups for changes in breathing (lung function), heart activity (EKG), blood pressure, and smoking-related chemicals found in urine.

The study consists of 3 in-person visits at the Milton S. Hershey Medical Center. At the first visit, eligibility will be confirmed, then participants will be provided with an electronic cigarette and asked to use the electronic cigarette as a complete replacement for their cigarettes, starting the very next day. Participants are followed up 3 and 6 weeks later.

150

The purpose of this project is to screen potential participants for multiple research studies being conducted by tobacco researchers at Penn State Hershey. Since there are multiple IRB approved studies enrolling at Penn State Hershey with similar but not identical inclusion/exclusion criteria, it is more efficient for the researchers and participants to have one phone number to call initially for basic screening. After completing this, the participant can be redirected for more specific screening if they are found to be potentially eligible for one of the studies.

Participants will fill out a 5-minute survey on tobacco use in order to find out which study they may be eligible for.

Depends on study

Substance misuse is a leading national problem, with young adults at high risk. We aim to develop a university resource that elucidates biobehavioral underpinnings of problematic student substance use at University Park campus. This initiative would inform services needed, provide engaged learning opportunities, connect with faculty, and catalyze high-impact, interdisciplinary research. In addition to this primary rationale, this study will allow us to capture detailed information about other critical student experiences such as food and housing insecurity, experiences of discrimination, and daily health practices to prevent the transmission of COVID-19. Participants will be asked to take a baseline survey followed by a 21- daily diary protocol (brief 5 minute survey each day for 21 days. For more information or to register interest in participating please see: https://projectself.psu.edu/register-your-interest/

This is a pilot study on the impact of switching from cigarettes to Electronic Cigarettes on disease-related clinical symptoms and biomarkers of harm in smokers with preexisting COPD

You will be asked to reduce your cigarette smoking and use study-provided e-cigarettes for one year. You will be asked to attend 5 in-person visits at the Hershey Medical Center and participate in 10 telephone visits. Throughout the study you will be asked to complete questionnaires, have heart rate, blood pressure and pulse oximetry taken, electrocardiograms (ECGs), height and weight measured, provide medical history, perform pulmonary function tests, complete a 6-minute walk, have your exhaled carbon monoxide measured, provide urine specimen and have blood drawn.

The goal of this study is to measure emotional and brain responses related to the motivation to smoke cigarettes. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. The study also involves measuring moment-to-moment changes in emotion by coding facial expressions. A primary goal of the project is to examine how changes in brain activity are related to changes in emotion over time. If successful, the project will help to demonstrate the usefulness of combining fMRI and facial coding to study cigarette smoking and other harmful behaviors.

There will be two in-person visits. Brain imaging scans (using functional magnetic resonance imaging) will be completed at one of these visits.

100

This study will examine the health effects of lowering the nicotine content in cigarettes while having access to an electronic cigarette.

There are a total of 8 study visits, 5 are in person and 3 are done virtually through a phone or computer. At the third visit you will be randomly assigned to one of two study cigarette groups AND one of two e-cigarette groups for 16 weeks. You will use the study cigarettes and e-cigarette throughout the study. During study visits you will be asked to complete questionnaires, provide urine samples, and complete other health measurements. You will record your cigarette and e-cigarette use every day.

$320

This is an intervention study that will examine the effect of black raspberry lozenges on mouth cell DNA damage in smokers.

Following one week of being in the study you will be given black raspberry lozenges to take 5 times daily for 8 weeks. Afterwards you will participate in the study for an additional 4 weeks for a ‘wash-out’ period where no lozenges are given. During study visits you will be asked to complete questionnaires, provide a urine sample, and a mouth cell sample by brushing the inside of your cheek with a toothbrush. You will smoke as you normally do throughout the study. You will record cigarette and lozenge use every day. You will complete 2 phone call interviews about your 24-hour food intake during the beginning and the end of the study.

$380