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Search Results Within Category "Addiction & Substance Abuse"

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16 Study Matches

Women, Opioid Use Disorder, and Criminal Justice: A Qualitative Study

Opioid-related overdose deaths and incarceration rates have skyrocketed and have disproportionately affected women. Despite having a higher burden of substance use disorders and HIV/AIDS than criminal justice-involved (CJI) men, CJI women are less likely to have access to substance use and HIV treatment. This qualitative study will conduct in-depth interviews with CJI women, MAT providers, and criminal justice professionals to identify facilitators and barriers to illicit opioid use cessation and related issues among CJI women.

No
 

Abenaa Jones
Abenaa Jones - at avj5462@psu.edu
Human Development and Family Studies (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00018974
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Inclusion Criteria:
women
substance use
opioid use
criminal justice
drug treatment

Exclusion Criteria:
Younger than 18 years of age
Addiction & Substance Abuse, Mental & Behavioral Health, Women's Health
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Testing the effect of ENDS flavors on Neurotransmission

Tobacco users will be randomized to use electronic cigarettes containing varying levels of nicotine and flavor during laboratory protocols to investigate the effects on the brain and behavior. Subjects will complete surveys, functional magnetic resonance imaging scans, and complete computerized tasks. Eligible participants include daily users of inhaled tobacco products who are at least 21 years old, able to read and write in English, and not planning to quit tobacco use within the next month. Exclusion criteria include: current substance use impairing participation, unstable or significant medical conditions, current use of smoking cessation medication, uncontrolled serious mental illness, and MRI safety or neurological contraindications.

Subjects will taste test a variety of e-cigarette flavorings, answer questions and complete a single MRI.

50

Yes
 

Andrea Hobkirk
Kenneth Houser - at abl@pennstatehealth.psu.edu or 717-531-5473
Psychiatry and Behavioral Health (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05836051
STUDY00019883
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Inclusion Criteria:
Daily inhaled nicotine user for over 1 year
No plan to quit tobacco use in the next month
Age 21 or older
Able to read and write in English

Exclusion Criteria:
MRI Contraindications
Unstable or Significant Medical Conditions
Uncontrolled serious mental illness
Current substance abuse
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Mental & Behavioral Health
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Hershey, PA ,

Recruitment for Nicotine and Tobacco Related Research at Penn State Hershey

The purpose of this project is to screen potential participants for multiple research studies being conducted by tobacco researchers at Penn State Hershey. Since there are multiple IRB approved studies enrolling at Penn State Hershey with similar but not identical inclusion/exclusion criteria, it is more efficient for the researchers and participants to have one phone number to call initially for basic screening. After completing this, the participant can be redirected for more specific screening if they are found to be potentially eligible for one of the studies.

Participants will fill out a 5-minute survey on tobacco use in order to find out which study they may be eligible for.

Depends on study

Yes
 

Jonathan Foulds
Nicolle Krebs - at smokingresearch@pennstatehealth.psu.edu or 844-207-6392
Public Health Sciences (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00002213
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Inclusion Criteria:
Age 21 or older
Current tobacco user

Exclusion Criteria:
Age less than 21
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Lung Disease & Asthma
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Harrisburg, PA ,
Hershey, PA ,
York, PA ,

Translational Studies on Electronic Cigarette-derived Oxidants and their Long-term Cardiopulmonary Effects

This is a pilot study on the impact of switching from cigarettes to Electronic Cigarettes on disease-related clinical symptoms and biomarkers of harm in smokers with preexisting COPD

You will be asked to reduce your cigarette smoking and use study-provided e-cigarettes for 3 months. You will be asked to attend 2 in-person visits at the Hershey Medical Center and participate in 4 telephone visits. Throughout the study you will be asked to complete questionnaires, have heart rate, blood pressure and pulse oximetry taken, electrocardiograms (ECGs), height and weight measured, provide medical history, perform pulmonary function tests, complete a 6-minute walk, have your exhaled carbon monoxide measured, provide urine specimen and have blood drawn.

Yes
 

Rebecca Bascom
Timothy Sheehan - at tsheehan@pennstatehealth.psu.edu or 717-531-2925
Medicine: Pulmonary, Allergy and Critical Care (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05239793
STUDY00015514
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Inclusion Criteria:
Ages 21-74
mild-moderate COPD
current smoker

Exclusion Criteria:
actively changing smoking behavior
current use of other tobacco products
allergic to vegetable glycerin and/or propylene glycol
chronic drug and/or alcohol abuse
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Lung Disease & Asthma
Approved device(s)
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Hershey, PA ,

Examining brain responses linked to emotion in individuals who smoke cigarettes

The goal of this study is to measure emotional and brain responses related to the motivation to smoke cigarettes. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. The study also involves measuring moment-to-moment changes in emotion by coding facial expressions. A primary goal of the project is to examine how changes in brain activity are related to changes in emotion over time. If successful, the project will help to demonstrate the usefulness of combining fMRI and facial coding to study cigarette smoking and other harmful behaviors.

There will be two in-person visits. Brain imaging scans (using functional magnetic resonance imaging) will be completed at one of these visits.

100

Yes
 

Stephen Wilson
Stephen Wilson - at sjw42@psu.edu
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04310735
STUDY00011266
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Inclusion Criteria:
Between 21 and 55 years old
Must smoke cigarettes each day
Must be right handed
Must be fluent English speaker
Must be willing to abstain from smoking for 12 hours during the study

Exclusion Criteria:
Must not be actively trying to quit smoking
Must not currently have significant cardiovascular or respiratory disease
Must not be claustrophobic
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Cancer
Not applicable
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State College, PA ,

The opioid epidemic among Pennsylvania immigrants: Insights from prescribers and rehabilitation professionals

We will interview prescribers and rehabilitation professionals who have provided services and treatment to immigrants in PA with a history of opioid abuse. The goal is to highlight best practices, resources needed, cultural awareness, and training needs to support the rehabilitation and recovery of this client group.

One 45-minute, recorded interview via Zoom

$50.00 Amazon gift card

No
 

Abigail Akande
Abigail Akande - at aoa29@psu.edu
Social and Behavioral Sciences (ABINGTON)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00021288
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Inclusion Criteria:
Medication Assisted Treatment Provider
Substance abuse treatment provider
Opiate pain medication prescriber
Service provider in PA
Provide services to immigrants (non-citizens)

Exclusion Criteria:
Working outside of PA
No experience with immigrant patients/clients
No experience with opioid use disorder
Addiction & Substance Abuse, Mental & Behavioral Health
Not applicable
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Understanding the Experiences of College Students of Color with Psychiatric Disabilities

The purpose of this study is to develop a better understanding of the lived experiences of college students of color with psychiatric disabilities, particularly related to the formation of racial identity, disability identity, and the impact of perceived discrimination.

Yes
 

Amber O'Shea
Amber O'Shea - at amo5208@psu.edu or 814-867-5721
Educational Psychology, Counseling and Special Education (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00014142
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Inclusion Criteria:
Currently enrolled as a college student
18 years of age or older
Capable of providing informed consent
Diagnosis of a psychiatric disability
Identify as a person of color

Exclusion Criteria:
Adults unable to provide legal consent
Individuals who are not yet legal adults
Prisoners
Unable to speak/read English Language at time of interview
Addiction & Substance Abuse, Education, Mental & Behavioral Health
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State College, PA ,

Slips of Action in Adolescents and Young Adults

Adolescence is a critical period during which many important healthhttps://irb.psu.edu/IRB/sd/ResourceAdministration/Project/ProjectEditor?Project=com.webridge.entity.Entity[OID[058ACDEB3E43384D816C7E390C2B83F6]]&Mode=smartform&WizardPageOID=com.webridge.entity.Entity[OID[E4552FC57E491543A6B7FD8268E23FD7]] habits form in humans. However, animal models provide mixed information about habit formation across development and there are relatively few human studies that address differences between habit formation in adolescents and adults. To address this gap, the proposed study will assess differences in habit formation in adolescents and adults as measured by the "Slips of Action" task, which seeks to discriminate between habitual and goal-directed learning of visual stimuli pairings.

There will be one in-person visit lasting about one hour. Visits will begin with informed consent. Participants will complete a computer task where they are asked to learn associations between pictures and then will be tested on the associated pairings. They will also complete questionnaires and cognitive tasks.

$20

Yes
 

Charles Geier
Katie Meeks - at kxm5964@psu.edu or 814-867-6472
Non-PSU Site
 

All
All
This study is also accepting healthy volunteers
STUDY00020521
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Inclusion Criteria:
Healthy adolescents between the ages of 13 to 17; (health based on parental report)
Healthy adults between the ages of 25 to 40
No learning disabilities (e.g., ADHD) or diagnosed psychological conditions (e.g. anxiety)
Right handed
Not on any medications known to influence behavior

Exclusion Criteria:
Outside of age ranges specified at baseline
Diagnosed neurological or psychological condition including severe anxiety and/or depression, schizophrenia, learning disability, ADD/ADHD, or autism
Significant family history of neurological or psychological disorders
Left handed
Participant is on any medication that may influence behavior
Addiction & Substance Abuse, Food & Nutrition, Mental & Behavioral Health
Not applicable
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Study Locations

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State College, PA ,

Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes

The goal of this study is to learn more about how people who smokecigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.

Yes
 

Stephen Wilson
Julian Peck - at jnp5021@psu.edu or 814-867-2333
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00003602
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Inclusion Criteria:
21-55 years of age
Right Handed
Smokes cigarettes

Exclusion Criteria:
under 21 years of age or over 55 years of age
Left Handed
non-smokers
Men's Health, Addiction & Substance Abuse, Women's Health
I'm interested
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Study Locations

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Altoona, PA ,
State College, PA ,

The opioid epidemic among Pennsylvania immigrants: Implications for treatment practices

We plan to interview PA immigrants who have first-hand experience with opioid abuse or who have friends/family/neighbors with opioid abuse experiences. The goal is to highlight areas for improvement, regarding access to treatment and quality of treatment for immigrants. We hypothesize that immigrant status uniquely impacts this group and their rehabilitation journeys, but this has not yet been studied.

There will be one semi-structured, qualitative interview over Zoom, for about 45 minutes. Interviews may be in-person if there is no Zoom access.

$75.00 gift card

No
 

Abigail Akande
Abigail Akande - at aoa29@psu.edu
Social and Behavioral Sciences (ABINGTON)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00021287
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Inclusion Criteria:
Immigrant (non-citizen)
PA resident
18 years of age and older
Experience with opioid abuse
Friend or family member with opioid abuse experience

Exclusion Criteria:
Reside outside of PA
U.S. citizen
Below 18 years of age
No opioid abuse experience
diagnosis of an intellectual/developmental disability
Addiction & Substance Abuse, Mental & Behavioral Health
Not applicable
I'm interested
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Linking brain network dynamics to smoking-related behavior

Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to reflect relevant mental processes as they change over time. However, methodological issues have hindered the ability to capitalize on this potential and prevented an understanding of how brain activity and corresponding psychological processes unfold in the critical moments that immediately precede a smoking lapse. The proposed project will address this knowledge gap using a novel fMRI paradigm adapted from a well-validated behavioral lapse task. The goals of the project are to characterize changes in brain activity that lead up to a lapse and to investigate how these changes are related to concurrent affect and subsequent cigarette use.

There will be two in-person visits, both will involve completion of computerized questionnaires and one will involve completing and MRI scan

175

Yes
 

Stephen Wilson
Stephen Wilson - at sjw42@psu.edu or 814-867-2333
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05572671
STUDY00020857
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Inclusion Criteria:
Smoke cigarettes
Age 21-65

Exclusion Criteria:
Ineligible for MRI scan
Claustrophobic
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Mental & Behavioral Health
Not applicable
I'm interested
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State College, PA ,

Emotion dynamics and alcohol use in NIAAA-defined recovery from alcohol use disorder

This study uses a baseline assessment and 28 days of ecological momentary assessment to examine the association of emotion dynamics to craving and alcohol use among people in the first year of cessation of heavy drinking and remission from DSM-5 AUD.

There will be one in person visit. Participants will be asked to complete baseline questionnaires. After the baseline assessment, participants will complete 28 days of daily diary questions on their cell phone. A prompt will be sent to the phone 3 times per day. It should take 5 minutes (15 minutes total/day) to complete the questions.

189

Yes
 

Brad Linn
Brad Linn - at blinn1@pennstatehealth.psu.edu or 717-531-0003, ext=321641
Family and Community Medicine (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00024054
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Inclusion Criteria:
Aged between 18-68
Have a history of a previous (AUD) in the past year
Live within commuting distance of the Penn State Clinical Research Center

Exclusion Criteria:
Acute psychosis
Bipolar disorder
Cognitive impairment
Active drug use disorder other than nicotine or cannabis dependence
Lack of sufficient familiarity with the English language to comprehend recruitment and consent procedures
Men's Health, Addiction & Substance Abuse, Mental & Behavioral Health
Not applicable
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Hershey, PA ,

How Does the Intersection of Gender and Language Affect Stigma in Opioid Use Disorder?

This research experimental study aims to investigate the impact of gender and language on stigma related to opioid use disorder (OUD) among college students. Participants, aged 18 and older, will be randomly assigned to read vignettes describing individuals with OUD, varying in gender and language use. After reading, participants will complete a brief survey assessing their perceptions of stigma associated with OUD. The study seeks to uncover how stigmatizing language and gender-specific societal expectations interact to shape attitudes, contributing to a better understanding of OUD stigma in the college-aged population.

Participants will engage in a structured series of activities. Initially, they will complete a demographics questionnaire, providing essential information such as age, gender, and college affiliation. Subsequently, participants will be presented with one of four vignettes designed to systematically manipulate language and gender variables related to OUD stigma. Following the vignette exposure, participants will respond to The Perceived Stigma of Substance Abuse Scale (PSSAS) as part of the survey.

No
 

Paul Christopher, Jr.
Paul Christopher - at pmc5584@psu.edu
Penn State Harrisburg
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00024114
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Inclusion Criteria:
College Students
18 years or older

Exclusion Criteria:
18 years or younger
Not a college student
Addiction & Substance Abuse
Not applicable
I'm interested
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Translational Study on Temperature and Solvent Effects on Electronic Cigarette-Derived Oxidants

Determine if free radicals produced by electronic cigarettes or conventional cigarettes impact inflammation and oxidative stress responses in users.

Subjects will come to the Clinical Research Center at Hershey and if they are a nicotine user they will bring their device (cigarette or e-cigarette) with them. Healthy volunteers will answer the same questionnaires and provide the same samples but will not use any nicotine during their visit. They will provide blood, urine, buccal cell and exhaled breath condensate samples. They will be videotaped using their own devices and they will answer questionnaires. This is a one-time visit that will last around 2 hours.

50

Yes
 

Thomas Spratt
smokingresearch@pennstatehealth.psu.edu
Biochemistry and Molecular Biology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00023965
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Inclusion Criteria:
21 years or older
For cigarette or e-cigarette users: No plan on quitting in the next 3 months
For e-cigarette users: E-cigarette use for more than 1 year
For cigarette users: Cigarette use for more than 1 year
For
Healthy volunteers
: No nicotine use via e-cigarette or cigarette use in the past year

Exclusion Criteria:
Respiratory diseases
Uncontrolled substance abuse
Pregnant or nursing
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse
Not applicable
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Hershey, PA ,

Nicotine absorption, toxicant exposure, and subjective effects of a heat-not burn tobacco product

The purpose of this study is to evaluate the nicotine delivery, toxicant exposure, and subjective effects associated with the use of heat-not burn tobacco products, compared with electronic cigarettes.

Participants will attend 2 clinic visits at the Penn State Milton S. Hershey Medical Center lasting approximately 1 ½ hours each. Participants will be asked to refrain from using any tobacco or nicotine products for at least 14 hours prior to each visit. During the visit participants will try the new tobacco products in the study center while blood samples are collected through an IV catheter placed in the arm.

120

Yes
 

Jonathan Foulds
Allison Salkin - at asalkin@pennstatehealth.psu.edu or 844-207-6392
Public Health Sciences (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00013801
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Inclusion Criteria:
Ages 21-60
Current daily cigarette smoker (5 or more per day)

Exclusion Criteria:
Currently pregnant
History of a seizure disorder or had a seizure in the past 12 months
History of difficulty providing or unwilling to provide blood samples
Current user of an IQOS device
Current user of an electronic cigarette device
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse
Not applicable
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Study Locations

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Hershey, PA ,

Oxidative Stress and Harmful Constituent Levels Associated with Little Cigars

The propose of this voluntary research study is to look at the effect of little cigars on biomarkers of potential harm with a focus on oxidative stress and inflammation. The study is also interested the effect of flavors in little cigar.

Subjects will attend 7 study visits over 7 weeks. They will be sent home with a selection of little cigars to use during the first week. Starting at week 2, they will be asked to smoke a certain cigar each week for the next 6 weeks at their study visit. They will be asked to answer a series of questionnaires and to provide biosamples (Exhaled Carbon Monoxide, Exhaled Breath Condensate and Spirometry).

600

Yes
 

Joshua Muscat
smokingresearch@pennstatehealth.psu.edu
Public Health Sciences (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT06310187
STUDY00023967
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Inclusion Criteria:
Aged 21-65
Daily tobacco smoker
No serious quit attempts in previous 30 days

Exclusion Criteria:
Pregant or trying to become pregnant
Respiratory diseases
Substance Abuse
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse
Not applicable
I'm interested
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See this study on ClinicalTrials.gov
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Study Locations

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Hershey, PA ,