Search Results Within Category "Children's Health"
Prevalence of Avoidant Restrictive Food Intake Disorder (ARFID) traits among children and adolescents with Food Allergy
This study looks at understanding eating behaviors and attitudes toward food in children/adolescents. More specifically the study's goal is to compare those with and without food allergies to gain a better understanding of a possible underlying factor towards certain behaviors. Children and their caregivers will complete a survey composed of a short section on the child's medical history regarding allergies followed with questions in commonly used clinical assessments.
Age 18 years or older
Intellectual disability preventing comprehension of questions
Child and/or caregiver unable to respond to English-language questionnaire
Attention and Emotional Development in Children
Children with attention problems often feel anxious or worried, and likewise, children who are anxious or worried often have problems with attention. We are looking for children aged 8-12 who may or may not have problems with attention or anxiety to help us understand what happens in the brain that could explain why. You will receive up to $100 gift card for your participation, and informal clinical feedback on your child.
Two in person visits of 2 hours each to the University Park campus, scheduled at the participant(s) convenience
$100
History of seizures or photosensitive epilepsy
Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony
Anxiety can emerge as early as pre-school age (4-6) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.
This is a longitudinal study examining the role that parent-child synchrony and emotional modeling plays in the transmission of anxiety. Participants will complete yearly laboratory visits and 6-month follow-up visits. The yearly laboratory visits (V1,3,5) will include a battery of tasks and questionnaires, but the six-month follow-up visits(V2,4) will only include online questionnaires. Participants at both Penn State and Washington University, St. Louis will follow the same procedures.
Participating families will be given $100 at each of V1 and V3, $25 for each of the follow-ups at V2 and V4, $100 and a $50 completion bonus at V5, for a total amount of $400.
Children without serious medical issues or complications
Parents or caregivers aged 18 or older
Children diagnosed with any neurological disorders and/or diseases
Children unable to communicate at a level similar to their peers
Children that have experienced a head injury with a loss of consciousness
Children 0 to 3 years of age; Children 7 and older
Caregiver's Perceptions of High-quality Early Education and Care
This is an exploratory study which looks at how caregivers define high-quality early education and care. Participants will fill out a questionnaire containing open-ended and closed-ended questions. It will take participants no longer than 20 minutes to complete.
Adults who are fluent in English
Adults who are regular caregivers of children between birth and age 5
Individuals who can read and respond to written close- and open-ended survey questions electronically
Individuals who live in the United States
Individuals who are not fluent in English
Individuals who are not regular caregivers of children between birth and age 5
Individuals with poor reading comprehension and are otherwise limited in their ability to read and respond to survey questions
Individuals who do not currently live in the United States of America
PEDS-PLAN – Pediatric Precision Laboratory Advanced Neuroblastoma Therapy
A study of the safety and feasibility of using molecularly guided therapy in combination with standard therapy followed by maintenance therapy with DFMO in patients with newly diagnosed high risk neuroblastoma.
Participating in this study requires that you visit the study hospital Penn State Hershey Medical Center multiple times over the course of the full study for evaluations (physical exam, blood draw, urine analysis, etc.) and scans (MRI/CT, MIBG). Weekly visits may occur at your home institution with your home treating oncologist. As a subject in this clinical trial you are expected to receive treatment on this phase of the study for a total of about 2 ½ years if you complete all portions. After treatment, you will have follow-up examinations and medical tests.
Must be 21 years of age or younger when diagnosed.
No prior systemic therapy with some exceptions.
Tumor samples will be obtained only in a non-significant risk manner and not solely for the purpose of the study.
Female patients who are lactating are not eligible unless they agree not toe breast feed.
The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.
The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.The aims of the PRIDE Program are to:1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered, or another IRB approved research protocol initiated blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure.2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants.3. Establish a mechanism for approving use of the banked biospecimens for future research.
The participant will meet with PRIDE Program team member in person to join the study.The participant with supply a saliva sample for the program.There is no compensation for joining the PRIDE Program.
Ability of patient, child and/or parent to understand or complete the consent process
Concussion-Diagnosis
The purpose of this research is to use saliva swab as a tool to diagnosis concussions and be able to differentiate a concussion and other medical conditions with the similar symptoms.
During their baseline visit participants will complete a saliva swab & surveys.Day 7, participants will complete a saliva swab and 2 surveys.Day 30, participants will complete a saliva swab and 4 surveys.The baseline visit is the only in-person visit, day 7 and day 30 are done remotely.All surveys are completed online and day 7 and day 30 saliva swabs are sent home with the participants and sent back in a prepaid mailer on day 30.
$20
Diagnosis of concussion
Monetary Reward Processing and Emotion Regulation in Adolescence: An fMRI pilot Study
This research is being done to identify patterns of brain activation underlying monetary reward processing and emotion regulation in adolescence, as well as correspondence between parent and adolescent neural activation.Children and their parents will complete questionnaires. Children will complete computer tasks during EEG and in an MRI scanner. Parents can also complete the MRI scan if interested.
Fluent in English
No history of treatment for psychiatric disorders
Visual or hearing impairments
Inability to complete MRI scan due a pacemaker, aneurysm clips or any metal in body (e.g., braces, surgical devices)
Currently pregnant or lactating
Neurological disease (e.g., stroke, tumor, Parkinson’s disease, etc.)
The HEALthy Brain and Child Development Study (HBCD)
This multi-site consortium research study, entitled the HEALthy Brain and Child Development (HBCD) study, will prospectively examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally through age 10 years. The study will determine the short- and long-term impacts of a variety of potentially harmful as well as protective environmental factors. These include prenatal substance use, mental health, stress, sociodemographics, biological and genetic factors, and parent/child interaction. The overall goal of this study is to understand the neurodevelopmental trajectories of children growing up in diverse environments. A sample of ~7,500 pregnant women will be recruited from 25 sites across the U.S. and they and their liveborn children will be followed for 10 years.
If you agree for you and your child to participate, we will ask you to take part in completing visits from pregnancy through the first 10 years of your child’s life. These visits will take place both in-person and remotely. The length of visits will vary and may last between approximately one to nine hours per visit (which can be broken up into multiple visits). Over the first four years of the study, all study visits will require about 33-37 hours total. This will include interviews, questionnaires and other tests about yourself and your child. We will ask you and your child to wear small devices for a few days to measure heart rate and or movement. We will ask you and your child to provide some biological samples. Because this study is looking at how a child’s brain develops in the first years of life, we will ask that you allow your child to have brain scans and other measures of how your child’s brain is developing. This study is being offered in both State College, PA at the University Park campus and in Hershey, PA at the College of Medicine campus. You may choose to complete this study at either site.
$1,350
Speaks English or Spanish
Does not speak English or Spanish
Sleep and eating behaviors in rural preadolescent children (Tween SPACE [Sleep Patterns, Appetite Control, and Environment])
The goal of this study is to learn about how children's sleep is related to their eating behaviors the next day. We are also interested in learning about factors that relate to eating behaviors and sleep health that are specific to preadolescent children living in rural communities. Participants will complete two virtual study visits via Zoom, answer surveys, and wear sleep and physical activity monitors for 2 weeks in their own homes.
- Study materials will be mailed to participants- Parent and child will attend a Zoom visit with a researcher to go over study procedures and measure child's height and weight- Child will wear a sleep monitor on their wrist and physical activity monitor around their waist continuously for 14 days- Child will attend a second Zoom visit to complete questionnaires- Parent will complete an online survey- Participants will return study materials via provided, prepaid shipping packaging
$200
Living in a rural zip code in United States (as defined by Health Resources & Services Administration)
Child BMI-for-age >=85th percentile OR BMI-for-age >=15th percentile plus one biological parent with overweight
Able to read and answer questions in English
Unable to connect to Zoom session via internet or cell-phone data
Unable to receive and sign for package with study supplies
Parent/child living in the same household as a previous or current participant in the study
Pennsylvania Adoptees Longitudinal Study (PALS)
This study will examine various factors within the home of children adopted from the child welfare system between the ages of 4 and 10 that may impact their development. The first visit will occur remotely via Penn State Health Microsoft Teams; the second visit is optional and will occur within 4 weeks of the first visit at the Transforming Lives of Children Center in Harrisburg, PA; and the third visit will occur one year after the first visit, when research staff will travel to participants' homes. This research will help understand the factors that impact the development of children adopted from the child welfare system and how we may better serve these children and their families.
The child and parent will be asked to complete interviews, questionnaires and various tasks. Parents may also be asked to complete questionnaires online.Participation will last for one year and include the following:-One visit occurring remotely via PSH Microsoft Teams-One visit at the Transforming the Lives of Children Center in Harrisburg, PA, four weeks after Zoom visit (optional)-Final visit at home will occur one year after the first Zoom visit
$225
Child legally adopted by the caregiver
The same caregiver will participate in each of the visits
A biological parent resides in the same home as the child
Characterizing resilience to food-cue induced overeating in children
This is a behavioral and neuroimaging study that will examine how food commercials affect the way a child eats and responds to food. Children enrolled in the study will complete 5 in-lab sessions that include eating meals and snacks, watching TV, and playing computer games. For one of these sessions, children will complete an fMRI scan. On the first and last visit to the lab, children will receive a DXA scan to assess their body composition.
We are looking for children to help us learn about how kids respond to different types of foods and food advertisements. The study consists of 5 visits to our facilities in Noll and Chandlee Labs, located on the University Park Campus. For 3 visits your child will eat test meals and snack buffets in our laboratory. On 1 visit we will use fMRI to take pictures of your child’s brain. We will use a DXA to scan for lean muscle and conduct an IQ test. These procedures are not harmful. You and your child will fill out questionnaires.Your child will also play computer games and watch commercials.
$250.00
Be 7-9 years-old at enrollment.
Not be taking any medications known to influence body weight, taste, food intake, behavior, or blood flow.
Have no learning disabilities (e.g., ADHD).
The biological mother must have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 (high-risk group).
If they have a learning disability, ADD/ADHD, language delays, autism or other neurological or psychological conditions.
If they have a pre-existing medical condition such as diabetes, rheumatoid arthritis, Cushing’s syndrome, Down’s syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, cerebral palsy, or can't engage in moderate exercise.
If they don’t speak English.
Biological mother must have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers (high-risk group), or they are excluded.
Expanding Family Foundations to 2nd-Time Parenthood - Focus Group
This focus group study, funded by Penn State's Social Science Research Institute, brings together couples with preschool-aged firstborns who are pregnant with their 2nd child or who have given birth to their 2nd child within the last 12 months. Couples will be interviewed about how they worked together as a team (as coparents) to prepare their firstborn for the birth of the second child and to prepare themselves for 2nd-time parenthood.
2.Each caregiver is over 18 years of age.
3.Caregivers are living together in the same household and are either married or living with a partner.
4.Families living independent of parents’ families of origin.
5.Both caregivers fluent in communicating in English.
2.Caregivers are under 18 years of age.
3.Caregivers not living together
4.Caregivers not living independently of their families of origin
5.Single-parent families with no live-in partner.
The Child Health Study
We want to understand how a child's environment affects biology in ways that impact child health
The project involves completing three Penn State ChildHealth Days on the University Park Campus in StateCollege, PA 2 years apart. Your child will receive a comprehensivehealth screening and you will be asked to completeseveral assessments about your child’s physical healthand emotional well-being. Travel and hotel costs arefree for eligible families.
520
Speak and understand English
Participation of a legal guardian
Development of Adolescent and Young Adult Social Health (DASH)
Adolescence is a unique developmental period that prepares individuals for adulthood. We are studying the behavioral and brain basis of this important time, particularly in terms of how adolescents understand and think about other people. To study this important developmental transition, we are inviting typically developing children (6-8 yrs), adolescents (10-14 yrs), and young adults (18-22 yrs) to help us with this study. Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. Volunteers are compensated for time (between $185-630) in the lab and for the neuroimaging session.If you are a parent and want to begin the screening process for you child, please go here https://pennstate.qualtrics.com/jfe/form/SV_51lN8sODiukYOONIf you are an adult, and want to begin the screening process please go here:https://pennstate.qualtrics.com/jfe/form/SV_5cXMng6ybKe0WwJ
Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. This study requires multiple in-person visits.
between $185-630
Normal vision and hearing (with correction)
Free of neuroneurologic, psychiatric, endocrinology disorders
Free of concussions with loss of consciousness
History of working with metal
Irremovable metallic implants in the body (e.g. braces)
Pregnancy
Weigh more than 250lbs or get claustrophobic in small spaces
Neurophysiological Markers of Pediatric Irritability and its Response to Intervention
This study uses specific computer tasks to predict irritability in children with Attention Deficit/Hyperactivity Disorder (ADHD), as well as the effect of ADHD medication (stimulants) on irritability symptoms in children with ADHD. Children ages between the ages of 5 and 12 years are eligible and must have an established diagnosis of ADHD or suspected symptoms of ADHD.
Children diagnosed with ADHD or suspected ADHD Symptoms
Children who are able to stop ADHD medication for testing days
Parent/child fluent in English
Children with visual or hearing deficits or sensitivity to loud noise
Neurological conditions such as active seizure disorder
Prominent traits or diagnosis of Autism, marked developmental delay, mania, psychoses, or suicidal ideation.
Validation and Feasibility of In-Home Child Height Measurement using a Portable Ultrasound Stadiometer
The goal if this study is to determine if a new tool (PUSH stadiometer) can be used by parents to accurately and easily measure children's height in their home.
Participants will be required to attend 1 Zoom visit and 1 in-person visit on Penn State's University Park Campus. Each of these visits will last 30 minutes or less.During the Zoom visit, a researcher will help parents use a new tool (PUSH Stadiometer) to measure their child's height in their home.At the in-person visit, a researcher will measure the child's height and weight, and parents will complete a short survey.
20
Parent age 18 years or older
Able to connect to a Zoom session from home
Able to read and answer questions in English
Fam Best Study (NIH)
The purpose of this research study is to understand how caregivers communicate with teenagers through the ups and downs of daily life. We would like to know how caregivers and teens in a modern family act around each other, and how family communication affects well being. The study is conducted all online (e.g., video chats and surveys on phones).
Caregiver-teen pairs will be asked to do the following:1. A 2-hour baseline Zoom appointment2. Brief 1-2 minute long surveys throughout the day for two weeks3. Provide brief video recordings of their interactions during car rides over the two-week period4. Carry study-provided smartphones with them at all times when not at school5. A 30-minute follow-up Zoom appointment
$160/person
Parent and youth live together at least 5 days/week
Parent has an active driver's license
Family has car that they use regularly
Primary language spoken at home is English
Youth has developmental disability (Autism spectrum disorders)
Youth or parent has had a suicide attempt, or intensive care (inpatient, partial hospitalization, daily outpatient) care for emotional or behavior problems in the past 12-months
Other social (ex: homelessness) or medical conditions that make participation difficult
Insulitis, Inflammation, Dietary intake and Omega-3 Biostatus of Youth with Partial Remission of Type 1 Diabetes
Only 50% of patients with type 1 diabetes (T1D) recover insulin secretion function after 3 months of initial diagnosis, and this phase is called partial remission (PR) of T1D, also called "Honeymoon phase". During this PR phase of T1D, patients recover the ability to secrete more than 50% of their insulin secretion function. This phase of PR typically lasts no longer than 6 or up to12 months, and has been frequently defined as requiring exogenous insulin below 0.5 units per kilogram per day, and hemoglobin A1C is typically below 7.5%. Most recently the use of a coefficient called IDAA1C ≤ 9 has became more accepted as the methodology to determine the development of partial clinical remission of T1D (honeymoon phase). Prior data published by the SEARCH study (national epidemiological study) showed that youth with prolonged honeymoon phase had higher intake of omega -3 fatty acids, vitamin D intake and leucine intake than those youth without prolonged honeymoon phase of T1D. Currently, there are not approved medications to prolong this phase of partial remission of type 1 diabetes, however inducing PR in youth with T1D could potentially decrease the risk of multi-organ damage caused by chronic severe hyperglycemia associated to the chronic hyperglycemia related to T1D.We aim to perform a case- multiple control study between youth with prolonged partial remission phase of T1D after one year of diagnosis, and compare these youths with multiple controls matched by age, gender, race, and puberty stage to study the potential protective factors associated to the development of prolonged partial remission of T1D.
Participants will be approached at their routine Pediatric diabetes clinic appointment. If participants agrees to be in the research, informed consent/assent will be reviewed and signed by all parties. Participant's parent/guardian will be asked to complete a questionnaire. The participant's glucose machine/insulin pump will be downloaded for study purposes. Participant will undergo a fingerstick and a blood draw to collect specific lab values as outlined in the consent.
$35.00
Age 1-17 years old, any gender
Attendance to the Pediatric diabetes clinic at Penn State Health in Hershey, PA
Most recent hemoglobin A1C below 7.5%
History of seafood allergies and/or milk/dairy related allergies
Medical conditions (such as severe cerebral palsy, etc.) that could make patients unable to communicate with the study team
Existence of other autoimmune diseases in addition to T1D requiring regular treatment with immunosuppressive or anti-inflammatory treatment
Diagnosis of type 2 diabetes, monogenic diabetes (MODY), secondary diabetes, pregnancy, compromised kidney function, or liver diseases
Decision-Making in ADHD: An Evaluation of the Subjective Value of Rewards and Costs
Children with attention and behavior problems often need external rewards to motivate them to perform challenging tasks, but we don’t yet know much about how children weigh potential rewards and the effort required to obtain the rewards. This research is being done to find out how children with varying levels of ADHD symptoms value rewards and costs when making decisions about whether or not to perform a difficult task.
There will be one in-person visit. Children will complete two computerized cognitive tasks (thinking games), and will be able to earn prizes from the points they earn on these tasks. Parents will also be asked to complete a few questionnaires that should take about 25 minutes to finish. Children can earn up to $50 in compensation for completing the study.
$50
Children with normal or corrected vision
Caregiver and child must be fluent in written and spoken English
Willing to stop stimulant medications, when appropriate, for research testing
Current or past diagnosis of autism spectrum disorder, schizophrenia or other psychotic disorders.
Current use of non-stimulant medication due to its extended washout period.
Physical disabilities that are incompatible with completing laboratory tasks such as hearing impairments, or visual impairments that cannot be corrected with visual aids (i.e., glasses, contacts).
Examining Maternal Reward Responsiveness and the Intergenerational Risk for Depression
Children of depressed mothers are at high risk for developing depression, particularly as youth age into adolescence, yet relatively little is known about the mechanism underlying risk for depression in youth with depressed mothers. The present study examines maternal reward responsiveness, measured across neurophysiological, behavioral, and self-report measures as a marker of depression in mothers of adolescents. Associations between maternal reward responsiveness and parenting difficulties often associated with maternal depression, as well as adolescent functioning will be examined, to explore the clinical impact of maternal reward responsiveness on the intergenerational transmission of depression.
Capacity for informed consent
Fluent in verbal and written English
Adolescent between the ages of 13 and 16 years (inclusive)
Any hearing or visual impairments
Investigator discretion regarding ability to participate in the study
Investigating the impact of food form on children’s ability to compensate for energy
This study is looking at how different apple products (apple juice, apple sauce, and apple slices) might affect children's hunger and fullness. During 5 visits to our laboratory at Penn State, children will participate in a variety of games and tasks, and will eat meals and snacks with a research assistant. Children must be between the ages of 4.5-6 years old to participate in this study.
There will be 5 in-person visits. During each visit, children will consume an apple-based snack (apple slices, apple sauce, or apple juice) before a meal. Children will also wear a small heart rate monitor during each visit. On each visit, different games and tasks will be completed with the children while the parent completes various surveys.
$200
No food allergies
Biologic and Environmental Impacts on Neurodevelopment and Growth (BEING)
Examine associations between biologic factors (genetic, epigenetic, transcriptomic, metabolomic) and environmental factors (family psychosocial dynamics, environmental allergens, diet, microbiome) in developing children, and their relationship with health and disease over the lifespan.
Depending on the age your child is when they are enrolled into the study will determine their designated enrollment group (Cohort 1, Cohort 2, Cohort 3, or Cohort 4) to determine how many study visits are required to complete participation in the study.For Cohort 1 participants (for infants enrolled at age 5-50 days):-11 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes at minimum a saliva swab sample**Infants will be asked to collect a stool sample for 3 study visits-Optional mother participant for breast-feeding mothers who will agree to provide a small breast milk sample for 3 study visits.For Cohort 2 participants (for children enrolled at age ~24 months):-8 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes a saliva swab sample**Children will be asked to collect a stool sample for 1 study visitFor Cohort 3 participants (for children enrolled at age 5-7 years):-5 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes a saliva swab sampleFor Cohort 4 participants (for children enrolled at age 12-14 years):-2 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes a saliva swab sample
30-100
Fluent in spoken/written English
Parent or legal guardian 18+ years old
Child ages: 5-50 days old, 2 years old, 5-7 years old, and 12-14 years old
Non-english speaking
Parent or legal guardian with decisional impairment
Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony
Anxiety can emerge as early as pre-school age (4-7) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.
Participation requires three steps; a remote video session with the primary parent, an in-lab visit scheduled with the primary parent and child, and then an additional set of questionnaires given to the secondary caregiver.The remote session consists of obtaining consent, 2 questionnaires, and a clinical interview. The in-lab visit typically lasts about 2-3 hours, consisting of two parent-child activities and several child-only activities. Participants will be asked to wear mobile eye-tracking glasses and special caps used to measures brain activity during some of the tasks.
$125, $100 for the primary parent/or child and $25 for secondary parent
Children ages 4 to 6
Children less than age 4 or over age 6
Interoception, the 8th Sensory System, Is it measurable?
Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.
Reading at 5th grade level in English
Healthy controls OR high functioning Autism
Under age 11 or over age 18
Cannot read English
Strong Foundations: Intervening to Promote Co-Parenting and Reduce Father Hazardous Drinking in Expectant Parents.
Our goal is to examine the efficacy of Strong Family Foundations parenting classes in reducing couple conflict, promoting co-parenting quality, parental sensitivity, and child development outcomes within families. We hope to enroll 220 couples in our parenting program. Participants will participate in parenting classes before and after the birth of their child, and research assessments 6 and 12 months postpartum.
Couples will be asked to participate in online parenting classes and family assessments during and after pregnancy. There are 3-5 prenatal and 1-4 postnatal classes that take place over Zoom. Family are also asked tp participate in 3 family assessments: 1 during pregnancy, 1 at 6 months of infant age, and one at 12 months of infant age. Families will be asked to complete inline surveys before each assessment. Additionally, families are asked to submit hair and saliva samples.
425.00
First time parents
18 years of age or above
English speaking
Both parents living together
Not pregnant with first child
Parents not living together
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
A study of DFMO for patients with neuroblastoma in remission.
Participating in this study requires that you visit the Penn State health Medical Center multiple times over the course of the full study for evaluations (physical exam, blood draw, urine analysis, etc.) and scans (MRI/CT, MIBG).If you agree to take part, you will receive treatment on this study for about 2 years and will be followed for survival for 5 years after the last dose of study drug. You will be asked to return to the research site approximately 15 times.
Must be in complete remission (CR).
Tests and scans will be required to confirm remission.
Patients who are currently receiving another study drug may not participate.
Patients who are currently receiving other anticancer agents may not participate.
Attitudes and ethical concerns toward use of TMS in depressed adolescents: a qualitative study of recipients and their parents
This project will examine adolescents', parents'/guardians', and society's attitudes toward the use of repetitive transcranial magnetic stimulation (rTMS) and theta burst stimulation (TBS) in adolescent depression. The attitudes and concerns of adolescents,their parents/guardians, and society around TMS are important as they can influence the uptake of the interventions, with adolescents playing an important role in assenting to the intervention, and parents/guardians consenting to treatment.
Participation will involve about 1 hour of your time in a semi-structured interview. We will have a separate 1 hour semi-structure interview with your child. The interviews will take place via Zoom or phone. Interviews will be recorded. Phone calls to Zoom meetings are encouraged, if phone calls are the preferred interview method.
$50.00
Adults with the capacity to consent
Able to conduct the interview in English
Children who lack the capacity to assent
Adults who llack the capacity to consent
Emotion Regulation and Mother-Infant Synchrony
The aim of this study is to better understand emotion regulation in infants by measuring brain, behavior, and mother-infant relational mechanisms. We plan to collect simultaneous brain activation in mothers and infants while they engage in a face-to-face interaction. We will then test associations between individual brain activation, mother-infant brain synchrony, and infant emotion regulation behaviors.
Participants complete questionnaires online, then come in for 1 in-person visit. Mother and baby complete a play and a neutral task while fNIRS is collected from them simultaneously.
40
Infants born 3 weeks within their due date.
Infants of a birth weight > 2500 g.
Infants with NO serious medical complications.
English-speaking families.
Infants who experienced any serious medical complications.
Infants who were born > 3 weeks before the indicated gestational period.
Families who do not understand and do not speak English
Predicting Concussion Outcomes with Salivary miRNA
The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows:1)Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years.2)Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Saliva collection and surveys at baseline, 7 days, and 30 Days
$20
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI