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Search Results Within Category "Pain Management"

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8 Study Matches

Acute to Chronic Pain Signatures in Traumatic Injury

The goal of the proposed project is to identify biosignatures that predict resilience or vulnerability to the transition from acute to chronic pain in a cohort of patients recovering from an acute musculoskeletal trauma.

There is one in person visit that will include a 30-min MRI scan, sensory testing, and blood draw. Two follow-up surveys will be sent to the participants at 3- and 6-months following their injury.

$200

Yes
 

Jennifer Nyland
Aimee Cauffman - at acauffman@pennstatehealth.psu.edu or 717-531-1617
Neural and Behavioral Sciences (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00017713
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Inclusion Criteria:
Age 18-70 years old
Presence of acute traumatic blunt chest trauma with multiple (≥ 2) closed fractures of the ribs
Non-surgical treatment of rib fractures
Able and willing to provide informed consent
Must be able to read and communicate in English sufficiently to complete all study requirements

Exclusion Criteria:
Surgical procedures on the chest during current admission (with exception of placement chest tube or rib platting)
Open rib fractures
Pregnant women
Single, isolated rib fractures
Presence of implanted ferromagnetic materials or devices
Pain Management
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Hershey, PA ,

Visceral Pain Sensation and Nav1.8

We wish to investigate the role of a specific gene in visceral pain sensation and perception. This gene, Nav1.8 has a known change present in 10% of the population which may affect the way we feel inflammatory pain in the gut. This is an important symptom in inflammatory bowel disease (IBD). Some patients feel high levels of pain we would like to control, other patients feel little to no pain in the presence of very active disease, which can lead to dangerously under-treated disease. In this study, we will use healthy volunteers of a known genotype for Nav1.8, and test their sensitivity using rectal balloon dilation.Research subjects will be asked to fast, skipping solid foods and opaque liquids for 6 hours before the testing. Usually this means skipping 1 meal. At the beginning of the study visit. they will use an over the counter enema to clear their rectum of any stool. Then. a trained physician on the research team will insert a thin, lubricated tube into the rectum, which will be inflated to specific pressures. Most of these tests will be designed to measure any change in sensation, then the need to use the toilet, followed by urgent need or discomfort, and lastly the lower threshold of pain. Patients will be able to stop testing at any time, should they become too uncomfortable. The testing takes between 1 and 1 and a half hours, and volunteers are compensated $200 for their time.

To simulate abdominal pain, we use a thin tube placed in the rectum that inflates a small balloon to very precise and safe pressures. Our bodies interpret these pressures (in ascending order) as the need to go to the bathroom; first just a little, then with increasing urgency and eventually discomfort and pain. During these experiments, we only measure the lower threshold of pain, and stop immediately when you tell us to stop. We have significant experience using this approach and we have found it consistently informative while causing the least amount of discomfort possible. The whole thing takes about an hour and we’re paying volunteers $200 for participating. We'll ask that you skip a meal before the study visit, and perform an over-the-counter enema at the start of the visit.

$200

Yes
 

Matthew Coates
August Stuart - at astuart@pennstatehealth.psu.edu or 717-531-0003, ext=281928
Medicine: General Internal Medicine (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00010688
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Inclusion Criteria:
Have a diagnosis of ulcerative colitis, Crohn's disease, or no lower GI diseases (healthy control)
Had a colonoscopy in HMC health record within the past 6 months (UC or Crhon's) or 5 years (healthy control)

Exclusion Criteria:
UC and Crohn's patients: moderate to severe disease activity on your recent colonoscopy
Healthy control: any diagnosed lower GI disease (such as IBS or active diverticulitis) or significant abdominal pain in the last 12 months.
Any peripheral neuropathy or neuromodulating/opioid medications
Any Autoimmune disease (except Crohn's disease or ulcerative colitis)
Infectious Diseases & Immune System, Digestive Systems & Liver Disease, Pain Management
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Hershey, PA ,
State College, PA ,

A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain

We are looking to conduct a study looking at the effects of cannabidiol (CBD) in patients with endometriosis. We believe that CBD will improve both pain and quality of life. The study will last a total of 12 weeks and involve several onsite visits in addition to daily pain assessments.

There will be five in person visitsblood will be drawn at all of these visits

$175

Yes
 

Kristin Riley
Barb Scheetz - at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Obstetrics and Gynecology (HERSHEY)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04527003
STUDY00013752
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Inclusion Criteria:
Females ages 18-45 years at the time of enrollment
Diagnosed with endometriosis by surgical diagnosis with direct visualization and/or histopathologic confirmation of endometriosis

Exclusion Criteria:
Women that are pregnant, breastfeeding or trying to conceive
Women with chronic daily opioid use ( > 14 days / month)
Women that are currently using Cannabis based products
Non-English speaking or inability to read and understand English
Pain Management, Women's Health
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Hershey, PA ,

A Pre-Post Study of the Use of Transcutaneous Electrical Nerve Stimulation Unit in the Management of Endometriosis Pain

The purpose of this study is see if Transcutaneous Electrical Nerve Stimulator (TENS) units help decrease endometriosis flare pain. Participants will complete surveys, record pain, medication use and bleeding in an online diary during endometriosis flare ups for 3 months without using the TENS unit. After the first 3 month period of time, a TENS unit will be given to participants to wear and again, record pain, medication use and bleeding in the online diary during endometriosis flare ups for and additional 3 months while using the TENS unit.

There will be one in person enrollment visit, involving being consented and completion of 2 surveys. The first 3 months, the "baseline period" will include filling out pain scores online on days of endometriosis flare without TENS unit use. The next 3 months, the "treatment period" will include filling out pain scores online on days of endometriosis flare with TENS unit. At end of study completion of 2 surveys.

Yes
 

Kristin Riley
Patricia Rawa - at prawa@pennstatehealth.psu.edu
Obstetrics and Gynecology (HERSHEY)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05348005
STUDY00019024
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Inclusion Criteria:
Women aged 18 to 45 years, inclusive,
Surgical diagnosis of endometriosis, visualized and/or pathology confirmed
Having monthly endometriosis pain flares on average
Has never used a TENS unit before for endometriosis pain flares
Must be greater than 12 weeks post-op for abdominal/pelvic surgery

Exclusion Criteria:
Has an implantable device (e.g. pacemaker, etc.)
Has a cardiac arrhythmia
Has open skin sores over area of TENS placement
Not planning to have surgery or hormonal medication changes during the study
Pregnant
Pain Management, Women's Health
Prefer not to display
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Hershey, PA ,

Couples' Daily Lives with Chronic Back Pain

The purpose of this study is to learn more about the daily experiences of people with back pain and their spouse/partner. Participants and their spouse/partner will be interviewed by video using a tablet computer every 6 months for 2 years and will be asked to complete daily surveys twice a day for 30 days using the provided tablet computer. The daily surveys will take about 5 to 10 minutes to complete. Questions for the interviews and daily surveys focus on physical symptoms, feelings, activities, and interactions.

Video interviews using a tablet computer every 6 months for 2 years. Complete daily surveys twice a day for 30 days using a tablet computer.

295.00

No
 

Lynn Martire
Kari Whitehead - at couplesstudy@psu.edu or 814-865-7094
Human Development and Family Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00013726
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Inclusion Criteria:
Individuals with back pain at least 65 years or older
Experienced moderate or severe back pain for at least 3 months
Married or in a long-term relationship AND living with spouse or partner

Exclusion Criteria:
Does not work more than 20 hours a week outside the home
Arthritis & Rheumatic Diseases, Pain Management
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The role of thromboxane A2 and its receptor in vascular regulation in women with endometriosis

Women with endometriosis have more thromboxane being produced in their platelets. Thromboxane affects blood vessels, making them constrict, and sensory nerves, making them more sensitive. This study will determine if women with endometriosis are negatively effected by the excess thromboxane.

There will be three in-person visits: one screening and two experimental visits. Participants will take aspirin before one visit and a placebo before the other then will undergo brief tests of nerve sensitivity and a blood draw.

$150

Yes
 

Lacy Alexander
Sue Slimak - at sks31@psu.edu or 814-863-8556
Kinesiology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT05962034
STUDY00021851
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Inclusion Criteria:
18-48 years
born with a uterus
with and without endometriosis

Exclusion Criteria:
diagnosed cardiovascular disease
hormone replacement therapy within previous 2 months
nicotine use
pregnant or breastfeeding
aspirin allergy or hypersensitivity
Heart & Vascular, Pain Management, Women's Health
Approved drug(s)
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Hershey, PA ,
State College, PA ,

The impact of structural racism and discrimination on chronic pain in Black or African American older adults: Biopsychosocial mechanisms

This study is trying to understand more about factors that cause pain in people who have had experiences of discrimination.

Study Requirements:-Two visits - each ~3 hours to the Milton S. Hershey Medical Center-Visit 1: computer questionnaires, sensory testing, mobility testing, blood draw-Visit 2: questionnaires, 1-hr MRI with painful but tolerable heat and sounds-At home questionnaires online between visits or added to second visit -Video and vital sign monitoring during some parts-Option to wear a smartwatch between visits for additional compensationStudy Compensation:-$175 with the option of up to $225-Visit 1: $100-Visit 2: $75-Smartwatch option: $50-Reimbursement for parking, transportation, or free ride via Uber Health-Souvenir copy of your brain scan

$225 + $25/visit transportation

Yes
 

Elizabeth Losin
Elizabeth Losin - at erl5393@psu.edu or 814-863-7256
Biobehavioral Health (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
SITE00001393
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Inclusion Criteria:
Musculoskeletal pain in lower back or knee for at least 3 months
Age 45 and up
Identify as Black or African American
Able to perform experimental tasks
Speak, read, and understand English

Exclusion Criteria:
Unable to tolerate MRI (e.g., claustrophobia)
Metal in body that is not safe for MRI
Previous abnormal MRI
Pregnancy
Muscle & Bone, Pain Management
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Harrisburg, PA ,
Hershey, PA ,

Understanding the Relationship Between Discrimination and Sickle Cell Pain

This is a survey and interview study recruiting patients with sickle cell disease (SCD). Participants will answer questionnaires and complete a remote interview about health care experiences, pain, and discrimination. Natural language processing of interview transcripts will be used to quantify linguistic features indicative of subjective associations between individual experiences of racial discrimination and sickle cell pain.

Participants will be asked to fill out questionnaires and answer questions during an interview.

$50

No
 

Elizabeth Losin
Jacob Gronemeyer - at jgronemeyer@psu.edu
Biobehavioral Health (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00023905
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Inclusion Criteria:
A diagnosis of Sickle Cell Disease
18 years or older

Exclusion Criteria:
Under the age of 18
Does not have a confirmed diagnosis of Sickle Cell Disease
Unable or unwilling to participate in the interview or to be recorded
Not Fluent in the English langauge
Blood Disorders, Pain Management
Not applicable
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