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Search Results Within Category "Muscle & Bone"

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18 Study Matches

To stretch, not strain: Impact of passive stretching on calf muscle and gait mechanics in peripheral artery disease

People with narrowed blood vessels in their legs can only walk a short distance before needing to sit down due to pain in their calf muscles. Most of these patients do not follow their heart doctor's advice to walk at home because it hurts. A therapy that does not involve painful walking would be ideal for these patients to begin to treat their disease so they can eventually walk with less discomfort. We will ask patients with peripheral artery disease (PAD) to place both feet into inflatable ankle splints 30 minutes a day for 4 weeks to passively stretch their calf muscles. Before and after this 4-week program, we will measure the health and size of their leg blood vessels, the length, and function of their calf muscles and tendons, and how long they can walk without pain. We will also closely track their joint and foot movements and calf muscle oxygen levels while they walk down a hallway. People with and without risk factors for heart disease are also eligible for this study to compare differences in vascular and muscular health to patients with PAD. Volunteers without a PAD diagnosis or poor leg circulation will not undergo the 4-week stretch and no-stretch interventions.

Peripheral artery disease (PAD) and poor leg circulation patients:-4 visits to University Park Clinical Research Center ~3 hours per visit-1 blood draw-Wear a calf muscle stretching device for 30-min a day, 5 days a week, for 4 weeks and 4 weeks of no stretching-Several muscle and vascular ultrasound measurements-Walking performance tests on and off the treadmill-Wear a smartwatch to monitor physical activity during each 4-week stretch or no stretch interventionParticipants with and without risk factors for heart disease:-2 visits to University Park Clinical Research Center within the same week lasting ~3 hours per visit-Not diagnosed with PAD or poor leg circulation-1 blood draw-Several muscle and vascular ultrasound measurements-Walking performance tests on and off the treadmill

PAD participants can receive up to $450 in compensation. Participants with and without heart disease risk factors (non-PAD participants) will receive $50 for their participation.

Yes
 

David Proctor
Jocelyn Delgado - at proctorlab@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT06041880
STUDY00022960
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Inclusion Criteria:
Patients (40-85 years) diagnosed with peripheral artery disease or poor leg circulation
Participants (40-85 years) with or without risk factors for heart disease (high blood pressure, blood sugar, cholesterol, etc.) and not diagnosed with PAD
Ability to walk on or off a treadmill at 1 mile per hour
Men and women who are not pregnant or nursing

Exclusion Criteria:
Cannot walk on a treadmill at a slow pace
Heart attack within the past 6 months or unstable angina
Severe lung disease, rheumatoid arthritis, degenerative joint disease, critical limb ischemia
Major surgery or lower extremity revascularization surgery within the past 6 months
Recent serious ankle, Achilles tendon, or foot injuries
Heart & Vascular, Muscle & Bone
Experimental device
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Altoona, PA ,
State College, PA ,

The Effects of Aircraft Seat Width on Passenger Comfort

The objective of this research is to determine the relationship between aircraft seat width and passenger comfort. Airlines are reducing the sizes of seats and improving their ability to fly planes at or near capacity. The combined effect is to decrease the quality of the experience of passengers. This work will help us to understand the degree to which comfort has been reduced.

Yes
 

Matthew Parkinson
Ritwik Biswas - at AirplaneResearch@psu.edu
School of Engineering Design and Innovation (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00012135
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Inclusion Criteria:
We are particularly interested in small and large participants.
You must be a healthy adult aged 18 years or older.

Exclusion Criteria:
Individuals under 18 years of age are not eligible.
Muscle & Bone, Mental & Behavioral Health
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State College, PA ,

AWS-PSU: Active Women's Study at Penn State University

AWS-PSU: Active Women's Study at Penn State University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.

Yes
 

Mary Jane De Souza
Nicole Aurigemma - at nca11@psu.edu or 814-863-4488
Kinesiology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
PRAMS00043507
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 16-29.9
No hormonal contraception for 6 months

Exclusion Criteria:
Smoking
Currently using medication impacting bone
Food & Nutrition, Muscle & Bone, Women's Health
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State College, PA ,

PLS Natural History Study

This study will provide a strong basis and foundation for future clinical trials that use historical controls. The study will collect clinical data and biological specimens to create a dataset and biorepository to be shared with other researchers as a foundation for future clinical trials.

This is a volunteer study for participants diagnosed with Primary Lateral Sclerosis (PLS) or suspected to have PLS by a neurologist. You will be expected to attend scheduled visits in person or by telephone, complete study testing and audio/video recordings. The study includes clinical measurements to assess disease status and motor function, a number of questionnaires, collection of biospecimens including DNA, blood, and urine, and an electromyography (EMG) test. There will be 6 visits over 24 months, of these 6 three will be in-person visits (2-3 hours) and the other three will be telephone calls (lasting about 45 minutes to an hour). Blood and urine samples will be collected during these visits.

$100 per in person visit (three) and $50 for telephone visit (three) completed.

Yes
 

Zachary Simmons
nervemuscle@pennstatehealth.psu.edu 717-531-8257
Neurology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00018274
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Inclusion Criteria:
Adult participants (≥ 25 years of age)
Symptom onset was no more than 15 years prior to baseline
Ability to independently walk with or without an assistive device (e.g., walker) at the baseline evaluation
In cases where a molecular test has been done prior to enrollment in this study, HSP or HSP-related mutations are negative
Expected to have at least some bulbar symptoms (dysarthria, dysphagia, drooling or pseudobulbar affect); however, the absence of these symptoms will not exclude participants when molecular testing is negative for known HSP

Exclusion Criteria:
Unwilling or unable to give informed consent
UMN symptoms and signs only in the legs
Unwilling or unable to visit the study site asrequired
Clinically obvious cognitive impairment that precludes obtaining informed consent, as determined by the site PI
Participating in clinical treatment trials
Neurology, Muscle & Bone, Mental & Behavioral Health
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Hershey, PA ,

Evaluation of calf muscle size and structure after an Achilles tendon rupture

The objective of this study is to compare to different methods of measuring the size of calf muscles: magnetic resonance (MRI) and ultrasound imaging. Participant will undergo a MRI scan (about 1 hour) and an ultrasound imaging session (about 1 hour). Images obtained from patients with Achilles tendon rupture will also be used to determine the feasibility of quantifying damage to the soleus muscle.

After you accept participating demographic questions will be asked. You will also be asked standard MRI safety/screening questions. These questions are used to determine that it is safe for you to participate in MRI research. You will be asked to leave metal objects and personal belongings and to remove any articles of clothing with metal before entering the MRI room. Please ask the experimenter if you are unsure about any items. If it is safe, an MRI will be performed on your leg. Additionally, several images will be taken from your leg using ultrasound. The ultrasound and MRI sessions can be performed the same day or in different days depending on your preference. Depending on scheduling constraints at the MRI facility, you may be scheduled for the ultrasound session first.

You will receive $25 after completing the MRI and $25 after completing the ultrasound imaging sessions.

Yes
 

Daniel Cortes Correales
Daniel Cortes - at dhc13@psu.edu or 814-863-3103
Mechanical and Nuclear Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04727047
STUDY00019121
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Inclusion Criteria:
Healthy individuals

Exclusion Criteria:
Contraindications to MRI
Previous Achilles injury (only for healthy individuals)
Muscle & Bone
Not applicable
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State College, PA ,

Defining the role of slow eye movements on limb motor control in younger and older adults

The purpose of this study is to define how eye movements contribute to eye-hand coordination in individuals of the age group 18-50 (young adults) and 65-80 (older adults). Specifically, the aim of the study is to understand how slow eye movements affect arm and hand movements. All procedures to be used in our study will be non-invasive. The task during the study will be performed with a robotic handle that participants will grasp with their right hand. They will interact with visual stimuli by moving the robotic handle. The robotic environmentwill attempt to simulate real-world mechanical interactions, such as those experienced during catching a ball.

During this study, we will ask you to come to our laboratory located in 23 Recreation Building,Pennsylvania State University, on two days separated by a maximum of 48 hours. Both sessions will last approximately 90-120 minutes. During the first session, we will review the procedures with you and if you agree to participate, you will sign this form and then proceed to perform the study. You will perform about 20-25 blocks of hand movements. Each block will consist of 24-30 trials and each trial will last between 3-5 seconds.The second day will be identical to the first day but the order of trials within a block will be changed.

$10/hour

Yes
 

Tarkeshwar Singh
Tarkesh Singh - at tsingh@psu.edu or 814-865-7851
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00024035
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Inclusion Criteria:
Participants should be between 18-80 years old.
Participants will be right-hand dominant individuals.
They will have normal or corrected-to-normal vision.
Participants should be able to sit upright in a chair for long periods (up to 2 and a half hours) with rest.
Participants should be able to grasp and move objects with both hands.

Exclusion Criteria:
Any history of neurological disorders.
Any history of musculoskeletal disorders
Eye or vision problems (e.g., cataracts, glaucoma, a detached retina or macular degeneration).
Cognitive impairment
Medication that could make the participant drowsy or tired during the experiment.
Neurology, Muscle & Bone, Vision & Eyes
Not applicable
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State College, PA ,

The Use of Micro-Doppler Radar to Identify Service Members at Risk for Musculoskeletal Injury: A Gold Standard Comparison

The purpose of this research study is to see if we can use micro-doppler signal technology to determine if someone has had an ACL reconstruction in the past. We will do this by comparing a group of people who have had the surgery against a group who has never had this surgery to see if this technology can tell the difference.

If you join this study you would be asked to come to a one-hour appointment at the Lebanon Valley College campus in Annville, PA and perform a variety of activities that are part of daily life, such as walking, jumping, and standing from a seated position. We'll ask you to complete a questionnaire on any musculoskeletal pain you're experiencing and report your demographic information.

50

Yes
 

Cayce Onks
Leonard Kishel - at lkishel@pennstatehealth.psu.edu or 717-531-0003, ext=321657
Family and Community Medicine (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020118
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Inclusion Criteria:
Ages 18-40
ACL Group: ACL Reconstruction surgery 9-72 months prior and approved to return to normal activities
Control group: No history of lower extremity surgery
Able to provide consent and read/write in English
No current musculoskeletal injuries

Exclusion Criteria:
Prisoner
Pregnant person
any surgery within 6 months of the study visit
Unable to provide consent or read/write in English
Unable to perform movements consistent with daily activities such as walking, jumping, or moving from sit to stand
Prevention, Sports Medicine, Muscle & Bone
Not applicable
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Hershey, PA ,

Interlimb differences in Motor Control and Learning

This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.

Yes
 

Robert Sainburg
Brooke Fosaaen - at sainburglab@psu.edu or 814-865-7937
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
PRAMS00040722
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Inclusion Criteria:
over the age of 18

Exclusion Criteria:
neurological disease
upper-extremity orthopedic injuries that interfere with participation
Neurology, Sports Medicine, Muscle & Bone
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Hershey, PA ,
State College, PA ,

The Biomechanics of Golf Performance

The purpose of this study is to determine what golf equipment and swing characteristics best predict playing ability in a population of golfers. Golfers will come to the laboratory and hit shots with various clubs while the movement of their body and the ball are tracked.

Participants will come to the Penn State Golf Teaching and Research Center and hit golf shots using their driver, 7 iron, and putter. A golf simulator will be used to track the ball trajectory. The movements of participant's body segments and the force they apply to the ground will be measured in three-dimensions as they swing. Participants will receive brief instruction from a Class-A PGA Professional upon completion.

Participants will receive brief instruction from a Class-A PGA Professional upon completion.

Yes
 

Eric Handley
Eric Handley - at esh12@psu.edu or 814-867-3198
Recreation, Park and Tourism Management (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00021404
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Inclusion Criteria:
Currently play golf
Between ages of 18-75
Physically able to play a full round of golf (i.e., 18 holes)

Exclusion Criteria:
Do not currently play golf
Not between ages of 18-75
Not physically able to play a full round of golf (i.e., 18 holes)
Education, Sports Medicine, Muscle & Bone
Not applicable
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State College, PA ,

VIBRANT: VIB4920 for Active Lupus Nephritis

A randomized placebo-controlled study to evaluate the efficacy and safety of VIB4920 in study participants with active lupus nephritis

Patients come for in-person visits at the Penn State Hershey main hospital location. There will be blood draws, physical exams, and questionnaires spread out across 60 weeks.

Yes
 

Nancy Olsen
Peri Newman - at pnewman@pennstatehealth.psu.edu or 717-531-0003, ext=287327
Medicine: Rheumatology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05201469
SITE00001277
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Inclusion Criteria:
Lupus nephritis
Systemic lupus erythematosus

Exclusion Criteria:
Pregnant
Transplant
Kidney & Urinary System, Arthritis & Rheumatic Diseases, Muscle & Bone
Experimental drug compared to a placebo/”sugar pill”
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Hershey, PA ,

Active Men's Study

Description: This research study is to assess energetic status, reproductive health, and bone health in a population of young exercising men. Secondarily, this study will also explore how diet, fitness, cardiovascular function, eating behaviors, stress, cognitive function, and sleep related to energy and reproductive outcomes in exercising men. Eligible young men (age 18-35) are those who are generally healthy and either a) exercising or b) not exercising.

There will be essentially 5 study visits - The first visit will include informed consent to take part in the study & completion of questionnaires and measurement of anthropometrics. Visit 2 will include tests of your metabolism, a blood draw, a saliva collection, and assessment of diet and physical activity. Visit 3 will be a short visit for a saliva collection. Visit 4 will include tests of stress (a hair sample), body composition, bone health, aerobic and anaerobic fitness, cognitive testing, and reproductive function. Visit 5 will consist of a results meeting and return of wearable devices and logs.

Yes
 

Mary Jane De Souza
Emily Lundstrom - at eal259@psu.edu
Kinesiology (UNIVERSITY PARK)
 

Male
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00017681
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Inclusion Criteria:
Age 18-35 years
BMI between 16-29.9 kg/m2
Non-smoker
For sedentary participants: less than 150 minutes of purposeful exercise per week
For exercising participants: at least 150 minutes of purposeful exercise per week (moderate to high intensity aerobic and/or resistance training).

Exclusion Criteria:
BMI >29.9 kg/m2 or <16 kg/m2
Procedures using contrast material within the past 7 days, including X-rays, MRI scans, CT scans, barium studies, nuclear medicine exams.
Currently a smoker or history of regular smoking
Prostheses
Vasectomy
Men's Health, Sports Medicine, Muscle & Bone
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State College, PA ,

Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities

We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion

No
 

Jacob Corey
Jacob Corey - at jjc6062@psu.edu or 814-865-1691
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00012768
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Inclusion Criteria:
At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year

Exclusion Criteria:
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
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Penn State Exercising Women's Study

This study aims to assess energy status in young sedentary and exercising women as it is related to menstrual status, bone health, psychological health, sleep variables, and cardiovascular function.

There will be three to four visits to the laboratory. Procedures include questionnaires, a blood draw, providing a hair sample, providing two saliva samples, cardiovascular measurements, and bone scans, as well as resting metabolic rate, cognitive, aerobic fitness, and countermovement jump testing. Participants will be asked to collect urine samples throughout one menstrual cycle, or 28 days for amenorrheic females. Exercise and physical activity will be recorded and monitored for seven days via logs and wearables. Food intake will be recorded for three days. Collegiate athletes will be tested twice; in-season and off-season.

Yes
 

Mary Jane De Souza
Ana Carla Chierighini Salamunes - at akc6247@psu.edu or 814-863-4488
Kinesiology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00019437
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Inclusion Criteria:
Women
Age 18-30 years
Body Mass Index between 16-29.9 kg/m2
For sedentary participants: less than 2 hours of purposeful exercise per week and regular menstrual cycles for the last 6 months (i.e. cycles between 26 and 35 days in length)
For exercising participants: exercise at least 2 hours per week AND/OR participate in collegiate athletics. Exercising participants can have regular or irregular menstrual cycles for the last 6 months.

Exclusion Criteria:
Pregnant or lactating
Currently a smoker or history of regular smoking
Taking any hormonal medication in the past six months, other than oral contraceptives
Serious or chronic health condition (including heart condition, thyroid illness, metabolic disease)
Hysterectomy or oophorectomy
Food & Nutrition, Muscle & Bone, Women's Health
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State College, PA ,

Tongue movement in adults with motor speech disorder

Tongue movement in adults with motor speech disorder

Yes
 

Ji Min Lee
Jimin Lee - at jxl91@psu.edu or 814-863-5338
Communication Sciences and Disorders (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
PRAMS00044147
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Inclusion Criteria:
be a native speaker of American English
have normal hearing
between 18 and 40 years of age
have no known speech, language, learning or neurological disorders
have very little experience in communicating with people that have motor speech disorders

Exclusion Criteria:
younger than 18 years of age; older than 40 years of age
Not a speaker of American English only
With hearing impairment
have neurologic and/or speech/language disorders
have extensive experience in communicating with people that have motor speech disorders
Neurology, Muscle & Bone, Language & Linguistics
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Hershey, PA ,
State College, PA ,

The effect of muscle shortening on the force-length characteristics of neighboring inactive muscles

We are trying to better understand the ways in which people contract their muscles. Specifically, we want to learn more about how connections between our muscles influence how they produce forces. Participants in this study will have their calf muscle group activated while we record the individual muscles' electrical activity and the length of the muscle fibers.This research will help us to understand the underlying mechanical function of muscles in a more realistic context. This understanding may also have profound implications for current computer models of muscles, which most often ignore the connectivity between muscles.

There will be one in-person visit. At this visit, participants will have their calf muscle group activated while we record the individual muscles' electrical activity and the length of the muscle fibers.

$50

Yes
 

Jonas Rubenson
Jonas Rubenson - at jxr75@psu.edu or 814-867-6209
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00019507
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Inclusion Criteria:
18-40 years old

Exclusion Criteria:
chronic or acute leg injury in last 12 months
heart condition
chest pain during exercise
balance or dizziness problems
prescribed drugs for blood pressure or heart condition
Muscle & Bone
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State College, PA ,

Modeling Transition Speeds in Elderly Human Walking

This study will involve elderly humans walking on a treadmill transitioning through prechosen speeds.

There will be one, two hour in person visit. Participants will change into specific lab provided clothing for study and reflective stickers will be placed on participants by the researcher. Participants will then get on the treadmill and will walk at prescribed constant speeds for about 5 minutes total. Then participants will perform 10 speed transition trials each of which lasts about 4 minutes.

$15

Yes
 

Ashley Zeman
Ashley Zeman - at apz5261@psu.edu or 724-759-1651
Division of Undergraduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00021984
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Inclusion Criteria:
65+ years old
Can continuously walk for up to 4 minutes
Be able to follow verbal instructions

Exclusion Criteria:
Active or existing neuromuscular, cardiovascular, vascular, or neurological pathologies, injuries, or illnesses affecting gait
High BMI (>30)
Neurology, Muscle & Bone
Not applicable
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State College, PA ,

Foot mechanics during gait with load carriage and toe elevation

This experimental study will investigate foot joint function during walking and running and/or hopping and performing heel raises. Participants will walk and run and/or complete heel raises with mass added to their body and will walk and run and/or hop with a plastic wedge secured to the underside of their toes.

Participants will walk and run and/or complete heel raises with mass added to their body and will walk and run and/or hop with a plastic wedge secured to the underside of their toes.

Yes
 

Ben Perrin
Ben Perrin - at bkp5431@psu.edu or 919-389-9898
Division of Graduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016164
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Inclusion Criteria:
Age 18-35
Run > 10 kilometers/week for past 6 months
If participant does not fit running criteria: Lifted weights of at least one bodyweight using barbell >= 2x/week for past 6 months

Exclusion Criteria:
Have had previous lower limb surgery
Experienced pain with walking, running, or (if applicable) weightlifting in past 6 months
Have had plantar fasciitis
Have osteoarthritis in lower limb
Have had diabetes 1 or 2
Sports Medicine, Muscle & Bone
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State College, PA ,

Metabolic Alterations of the Semitendinosus Muscle After Tendon Harvest for Anterior Cruciate Ligament Reconstruction

This is a cohort study examining the changes in the muscle that occur following ACL injury and reconstruction. This study aims to determine if significant changes to the muscles properties occur as a result of the graft taken for ACL reconstruction, and whether or not these changes serve as a risk factor for further injuries. This study will examine the muscles ability to use oxygen non-invasively, an important determinant of muscle endurance and allow for comparisons of this between individuals with ACL-reconstruction surgery and healthy, non-injured adults.

Participants will have their leg muscle strength and endurance measured using common clinical techniques used in physical medicine and rehabilitation sciences. They will also have their mitochondrial capacity assessed through the skin using a non-invasive procedure.

$60.00

Yes
 

Giampietro Vairo
Jigar Gosalia - at jzg691@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00010623
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Inclusion Criteria:
ACL tear within last 12-36 months
Full rehabilitation
autograft taken from hamstring tendon
other autografts may be considered
Recreationally active

Exclusion Criteria:
Other major knee injury (i.e. MCL tear)
Muscle & Bone
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State College, PA ,