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Search Results Within Category "Children's Health"

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41 Study Matches

NMTRC012: PEDS-PLAN – Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

A study of the safety and feasibility of using molecularly guided therapy in combination with standard therapy followed by maintenance therapy with DFMO in patients with newly diagnosed high risk neuroblastoma.

Participating in this study requires that you visit the study hospital Penn State Hershey Medical Center multiple times over the course of the full study for evaluations (physical exam, blood draw, urine analysis, etc.) and scans (MRI/CT, MIBG). Weekly visits may occur at your home institution with your home treating oncologist. As a subject in this clinical trial you are expected to receive treatment on this phase of the study for a total of about 2 ½ years if you complete all portions. After treatment, you will have follow-up examinations and medical tests.

Yes
 

Valerie Brown
Suzanne Treadway, MS, RN, CCRP - at streadway@pennstatehealth.psu.edu or 717-531-3097
Pediatrics: Hematology/Oncology (HERSHEY)
 

All
All
This study is NOT accepting healthy volunteers
NCT02559778
STUDY00003478
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Inclusion Criteria:
A confirmed diagnosis of neuroblastoma.
Must be 21 years of age or younger when diagnosed.
No prior systemic therapy with some exceptions.
Tumor samples will be obtained only in a non-significant risk manner and not solely for the purpose of the study.

Exclusion Criteria:
Receiving another study drug while on this study.
Female patients who are lactating are not eligible unless they agree not toe breast feed.
Children's Health, Cancer
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Hershey, PA ,

Neurophysiological Markers of Pediatric Irritability and its Response to Intervention

This study uses specific computer tasks to predict irritability in children with Attention Deficit/Hyperactivity Disorder (ADHD), as well as the effect of ADHD medication (stimulants) on irritability symptoms in children with ADHD. Children ages between the ages of 5 and 12 years are eligible and must have an established diagnosis of ADHD or suspected symptoms of ADHD.

Yes
 

Raman Baweja
Vanessa Cao - at vcao@pennstatehealth.psu.edu or 717-531-0003, ext=285966
Psychiatry and Behavioral Health (HERSHEY)
 

All
Younger than 18 years old
This study is NOT accepting healthy volunteers
NCT03279952
STUDY00008087
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Inclusion Criteria:
Children between the ages of 5 and 12
Children diagnosed with ADHD or suspected ADHD Symptoms
Children who are able to stop ADHD medication for testing days
Parent/child fluent in English

Exclusion Criteria:
Children younger than 5 year or older than 12 years
Children with visual or hearing deficits or sensitivity to loud noise
Neurological conditions such as active seizure disorder
Prominent traits or diagnosis of Autism, marked developmental delay, mania, psychoses, or suicidal ideation.
Children's Health, Mental & Behavioral Health
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Hershey, PA ,

Validation and Feasibility of In-Home Child Height Measurement using a Portable Ultrasound Stadiometer

The goal if this study is to determine if a new tool (PUSH stadiometer) can be used by parents to accurately and easily measure children's height in their home.

Participants will be required to attend 1 Zoom visit and 1 in-person visit on Penn State's University Park Campus. Each of these visits will last 30 minutes or less.During the Zoom visit, a researcher will help parents use a new tool (PUSH Stadiometer) to measure their child's height in their home.At the in-person visit, a researcher will measure the child's height and weight, and parents will complete a short survey.

20

Yes
 

Emily Hohman
Emily Hohman - at eeh12@psu.edu or 814-865-5245
Center for Childhood Obesity Research (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00020741
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Inclusion Criteria:
Child age 3-18 years
Parent age 18 years or older
Able to connect to a Zoom session from home
Able to read and answer questions in English

Exclusion Criteria:
Child has a medical condition that interferes with standing upright (e.g., paralysis, severe scoliosis)
Children's Health, Prevention
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State College, PA ,

Attention and Emotional Development in Children

Children with attention problems often feel anxious or worried, and likewise, children who are anxious or worried often have problems with attention. We are looking for children aged 8-12 who may or may not have problems with attention or anxiety to help us understand what happens in the brain that could explain why. You will receive up to $100 gift card for your participation, and informal clinical feedback on your child.

Two in person visits of 2 hours each to the University Park campus, scheduled at the participant(s) convenience

$100

Yes
 

Cynthia Huang-Pollock
Christina Hlutkowsky - at ChildAttention@psu.edu or 814-863-0250
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00005954
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Inclusion Criteria:
Children aged 8-12

Exclusion Criteria:
Children outside of the 8-12 age range
History of seizures or photosensitive epilepsy
Children's Health, Mental & Behavioral Health
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Altoona, PA ,
State College, PA ,

Advanced fMRI Study on the Functional Abnormality of BNST in Anorexia Nervosa Restricting-type

This research is being done to better understand how certain parts of the brain may react differently in people who have a particular eating disorder, anorexia nervosa, which may help us understand why they respond to food in the way they do. This may help us design more effective treatments for people with anorexia nervosa.

You will complete a package of surveys for personality, psychopathology, an evaluation of taste functions, and an MRI/fMRI examination.

Up to a total of $100.

Yes
 

Jian-Li Wang
Nicholas Corbett - at ncorbett@pennstatehealth.psu.edu or 717-531-0003, ext=323023
Radiology (HERSHEY)
 

Female
All
This study is also accepting healthy volunteers
STUDY00021467
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Inclusion Criteria:
Age 10 to 24 years-old female
Anorexia nervosa restricting type patients
Healthy volunteer with normal body weight
Right-handed
Fluent in written and spoken English

Exclusion Criteria:
Left-handed
Pregnancy or breastfeeding
History of diabetes, substance abuse, head trauma
Allergy to milk and milk products
Cannot have MRI due to claustrophobia or specific implants
Children's Health, Mental & Behavioral Health
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Hershey, PA ,

Califormula Study: Calibrated Formula Feeding to Optimize Infant Growth

This pilot study seeks to determine if formula feeding recommendations that are adjusted using age and weight specific caloric intake recommendations can prevent excessive infant weight gain and reduce overweight in the first 6 months after birth among infants born to mothers with overweight prior to pregnancy electing to exclusively formula feed their infants.

There will be 5-7 visits, where you will record formula volumes on diary cards for a total of 6 days per visit, and be given formula volume recommendations if you are in the intervention group. All participants will complete surveys when their infants are 1 and 6 months of age.

$300

Yes
 

Ian Paul
Courtney Byrnes - at cbyrnes@pennstatehealth.psu.edu or 717-531-0003, ext=322458
Pediatrics: General Pediatrics (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT05104073
STUDY00018788
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Inclusion Criteria:
Formula-fed infants
Term or Early term Infants (≥37 weeks)
Infant birthweight ≥50th percentile

Exclusion Criteria:
Infants who weigh less than their birthweight between 14-21 days after delivery
Children's Health, Food & Nutrition
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Hershey, PA ,

Normalizing preteen HPV vaccination with practice-based communication strategies (Protect Them)

This study seeks to adapt and test a culturally-relevant, web-based game intervention to motivate Spanish-speaking preteens to initiate and complete human papillomavirus (HPV) vaccination. The present study will adapt an existing web-based game developed as an educational tool on HPV vaccination for English-speaking preteens in North Carolina. The study includes the recruitment of paired dyads (Spanish-speaking preteens and parents) to focus groups to evaluate the acceptability of cultural adaptations to the existing web-based game intervention. We will recruit up to 25 parents and preteens ages 11-12 who will receive a link to the Spanish game to play for 7-10 days in advance of the focus group discussions. The focus groups will ask participants about cultural and language adaptations to the existing game and how they react to a game that will serve as an interactive, educational tool on HPV vaccination. The focus groups will take place in Harrisburg, PA between January and March of 2018. No health information will be collected as part of this study.

Yes
 

William Calo
William Calo - at wcalo@phs.psu.edu or 717-531-3535
Public Health Sciences (HERSHEY)
 

All
All
This study is also accepting healthy volunteers
SITE00000339
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Inclusion Criteria:
Pretens 11 or 12 years old
Not vaccinated with the HPV vaccine
Have computer, tablet, or smartphone

Exclusion Criteria:
Having received the HPV vaccine
Children's Health, Prevention
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Harrisburg, PA ,

Biologic and Environmental Impacts on Neurodevelopment and Growth (BEING)

Examine associations between biologic factors (genetic, epigenetic, transcriptomic, metabolomic) and environmental factors (family psychosocial dynamics, environmental allergens, diet, microbiome) in developing children, and their relationship with health and disease over the lifespan.

Depending on the age your child is when they are enrolled into the study will determine their designated enrollment group (Cohort 1, Cohort 2, Cohort 3, or Cohort 4) to determine how many study visits are required to complete participation in the study.For Cohort 1 participants (for infants enrolled at age 5-50 days):-11 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes at minimum a saliva swab sample**Infants will be asked to collect a stool sample for 3 study visits-Optional mother participant for breast-feeding mothers who will agree to provide a small breast milk sample for 3 study visits.For Cohort 2 participants (for children enrolled at age ~24 months):-8 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes a saliva swab sample**Children will be asked to collect a stool sample for 1 study visitFor Cohort 3 participants (for children enrolled at age 5-7 years):-5 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes a saliva swab sampleFor Cohort 4 participants (for children enrolled at age 12-14 years):-2 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email-Each study visit includes a saliva swab sample

30-100

No
 

Steven Hicks
Alexandra Confair - at aconfair1@pennstatehealth.psu.edu or 717-531-0003, ext=323206
Pediatrics: General Pediatrics (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00014022
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Inclusion Criteria:
Child participant under 18 years old
Fluent in spoken/written English
Parent or legal guardian 18+ years old
Child ages: 5-50 days old, 2 years old, 5-7 years old, and 12-14 years old

Exclusion Criteria:
Wards of the state
Non-english speaking
Parent or legal guardian with decisional impairment
Children's Health
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Prevalence of Avoidant Restrictive Food Intake Disorder (ARFID) traits among children and adolescents with Food Allergy

This study looks at understanding eating behaviors and attitudes toward food in children/adolescents. More specifically the study's goal is to compare those with and without food allergies to gain a better understanding of a possible underlying factor towards certain behaviors. Children and their caregivers will complete a survey composed of a short section on the child's medical history regarding allergies followed with questions in commonly used clinical assessments.

No
 

Jodi Brady-Olympia
Jodi Brady-Olympia - at jbradyolympia@pennstatehealth.psu.edu or 717-531-1383
Pediatrics: General Pediatrics (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00015831
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Inclusion Criteria:
Ages 8-17

Exclusion Criteria:
Age under 8 years old
Age 18 years or older
Intellectual disability preventing comprehension of questions
Child and/or caregiver unable to respond to English-language questionnaire
Children's Health, Allergies, Food & Nutrition
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Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony

Anxiety can emerge as early as pre-school age (4-7) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.

Participation requires three steps; a remote video session with the primary parent, an in-lab visit scheduled with the primary parent and child, and then an additional set of questionnaires given to the secondary caregiver.The remote session consists of obtaining consent, 2 questionnaires, and a clinical interview. The in-lab visit typically lasts about 2-3 hours, consisting of two parent-child activities and several child-only activities. Participants will be asked to wear mobile eye-tracking glasses and special caps used to measures brain activity during some of the tasks.

$125, $100 for the primary parent/or child and $25 for secondary parent

Yes
 

Koraly Perez-Edgar
Dakota Reis - at drr5484@psu.edu or 814-867-2322
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00017857
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Inclusion Criteria:
Parents/Caregivers over 18
Children ages 4 to 6

Exclusion Criteria:
major medical illness
Children less than age 4 or over age 6
Children's Health, Mental & Behavioral Health
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State College, PA ,

The Role of Parental Emotion Regulation in Parent-Child Conflicts

This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.

Participants will complete C-DISC while caregiver will complete rating scales around ADHD, ODD, and CD symptoms during initial visit. On the second visit, participants will complete emotion regulation tasks while EEG data is collected. Caregivers will also complete a monetary task while connected to EEG equipment. Parents will use LifeData to report inattentiveness, hyperactivity, and oppositional behaviors over 14 days. Optional parent child interaction and 8-week parenting intervention are offered to participating families.

$50

Yes
 

James Waxmonsky
james waxmonsky - at jwaxmonsky@pennstatehealth.psu.edu or 717-531-8646
Psychiatry and Behavioral Health (HERSHEY)
 

All
Younger than 18 years old
This study is NOT accepting healthy volunteers
STUDY00006470
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Inclusion Criteria:
Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD

Exclusion Criteria:
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study
Children's Health, Mental & Behavioral Health
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Hershey, PA ,

Interoception, the 8th Sensory System, Is it measurable?

Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.

No
 

Cheryl Tierney
Cheryl Tierney - at ctierney@pennstatehealth.psu.edu or 717-531-8414
Pediatrics: General Pediatrics (HERSHEY)
 

All
All
This study is also accepting healthy volunteers
STUDY00004312
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Inclusion Criteria:
Ages 11-18
Reading at 5th grade level in English
Healthy controls OR high functioning Autism

Exclusion Criteria:
Unable to read at 5th grade reading level
Under age 11 or over age 18
Cannot read English
Children's Health, Mental & Behavioral Health
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The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.

The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.The aims of the PRIDE Program are to:1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered, or another IRB approved research protocol initiated blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure.2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants.3. Establish a mechanism for approving use of the banked biospecimens for future research.

The participant will meet with PRIDE Program team member in person to join the study.The participant with supply a saliva sample for the program.There is no compensation for joining the PRIDE Program.

Yes
 

James Broach
Molly Pells - at IPM@pennstatehealth.psu.edu or 855-369-3540
Biochemistry and Molecular Biology (HERSHEY)
 

All
All
This study is also accepting healthy volunteers
PRAMS00040532
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Inclusion Criteria:
Any age
Ability of patient, child and/or parent to understand or complete the consent process

Exclusion Criteria:
Unable to understand or complete the consent process
Men's Health, Children's Health, Women's Health
Not applicable
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Hershey, PA ,

Strong Foundations: Intervening to Promote Co-Parenting and Reduce Father Hazardous Drinking in Expectant Parents.

This is a randomized efficacy trial of a family and alcohol intervention (mFF+) for expecting couples with heavy drinking fathers and light drinking/abstaining (in pregnancy) mothers. We propose to test an innovative preventive strategy by adapting an evidence-based preventive intervention for couples at the transition to parenthood - Family Foundations (FF) - to yield a multi-modal intervention that incorporates alcohol content into existing modules of FF and adding alcohol screening and brief intervention (SBI) for hazardous drinking. This is a multi-PI application with Drs. Eiden (at Penn State) and Godleski (at Rochester Institute of Technology) as co-PIs. Dr. Colder (at the University at Buffalo (UB)) is a co-investigator and will serve as PI of the UB subcontract. Families will be recruited in Western New York (Buffalo and Rochester). Investigators at Penn State (Drs. Eiden and Feinberg) will provide training and supervision. Data management and analyses will occur at Penn State

Couples will be asked to participate in online parenting classes and family assessments during and after pregnancy. There are 3-5 prenatal and 1-4 postnatal classes that take place over Zoom. Family are also asked tp participate in 3 family assessments: 1 during pregnancy, 1 at 6 months of infant age, and one at 12 months of infant age. Families will be asked to complete inline surveys before each assessment. Additionally, families are asked to submit hair and saliva samples.

425.00

No
 

Rina Eiden
Rebecca Lim - at becca.lim@psu.edu or 814-865-6902
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04441307
SITE00000607
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Inclusion Criteria:
Pregnant/Expecting Couples
First time parents
18 years of age or above
English speaking
Both parents living together

Exclusion Criteria:
Below 18 years of age
Not pregnant with first child
Parents not living together
Children's Health, Pregnancy & Infertility, Women's Health
Survey(s)
I'm interested
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Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony

Anxiety can emerge as early as pre-school age (4-6) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.

This is a longitudinal study examining the role that parent-child synchrony and emotional modeling plays in the transmission of anxiety. Participants will complete yearly laboratory visits and 6-month follow-up visits. The yearly laboratory visits (V1,3,5) will include a battery of tasks and questionnaires, but the six-month follow-up visits(V2,4) will only include online questionnaires. Participants at both Penn State and Washington University, St. Louis will follow the same procedures.

Participating families will be given $100 at each of V1 and V3, $25 for each of the follow-ups at V2 and V4, $100 and a $50 completion bonus at V5, for a total amount of $400.

Yes
 

Koraly Perez-Edgar
Kimberly Labra-Franco - at kml7098@psu.edu
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00019415
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Inclusion Criteria:
Families with children between the ages of 4 and 6
Children without serious medical issues or complications
Parents or caregivers aged 18 or older

Exclusion Criteria:
Families that cannot communicate in either English, Spanish, or a language with an available translator
Children diagnosed with any neurological disorders and/or diseases
Children unable to communicate at a level similar to their peers
Children that have experienced a head injury with a loss of consciousness
Children 0 to 3 years of age; Children 7 and older
Children's Health, Mental & Behavioral Health
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State College, PA ,

Characterizing resilience to food-cue induced overeating in children

This is a behavioral and neuroimaging study that will examine how food commercials affect the way a child eats and responds to food. Children enrolled in the study will complete 5 in-lab sessions that include eating meals and snacks, watching TV, and playing computer games. For one of these sessions, children will complete an fMRI scan. On the first and last visit to the lab, children will receive a DXA scan to assess their body composition.

We are looking for children to help us learn about how kids respond to different types of foods and food advertisements. The study consists of 5 visits to our facilities in Noll and Chandlee Labs, located on the University Park Campus. For 3 visits your child will eat test meals and snack buffets in our laboratory. On 1 visit we will use fMRI to take pictures of your child’s brain. We will use a DXA to scan for lean muscle and conduct an IQ test. These procedures are not harmful. You and your child will fill out questionnaires.Your child will also play computer games and watch commercials.

$250.00-450.00

Yes
 

Kathleen Keller
Ben Baney - at bab349@psu.edu or 814-753-1005
Nutritional Sciences (UNIVERSITY PARK)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT05073185
STUDY00015835
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Inclusion Criteria:
In order to be enrolled, children must be of good health based on parental self-report.
Be 7-9 years-old at enrollment.
Not be taking any medications known to influence body weight, taste, food intake, behavior, or blood flow.
Have no learning disabilities (e.g., ADHD).
The biological mother must have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 (high-risk group).

Exclusion Criteria:
They are not within the age requirements (< than 7 years old or > than 9 years-old at baseline).
If they have a learning disability, ADD/ADHD, language delays, autism or other neurological or psychological conditions.
If they have a pre-existing medical condition such as diabetes, rheumatoid arthritis, Cushing’s syndrome, Down’s syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, cerebral palsy, or can't engage in moderate exercise.
If they don’t speak English.
Biological mother must have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers (high-risk group), or they are excluded.
Children's Health, Food & Nutrition, Prevention
Not applicable
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State College, PA ,

NMTRC014: NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)

A study of DFMO for patients with neuroblastoma in remission.

Participating in this study requires that you visit the Penn State health Medical Center multiple times over the course of the full study for evaluations (physical exam, blood draw, urine analysis, etc.) and scans (MRI/CT, MIBG).If you agree to take part, you will receive treatment on this study for about 2 years and will be followed for survival for 5 years after the last dose of study drug. You will be asked to return to the research site approximately 15 times.

Yes
 

Valerie Brown
Suzanne Treadway, MS, RN, CCRP - at streadway@pennstatehealth.psu.edu or 717-531-3097
Pediatrics: Hematology/Oncology (HERSHEY)
 

All
All
This study is NOT accepting healthy volunteers
NCT02679144
STUDY00004295
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Inclusion Criteria:
A confirmed diagnosis of neuroblastoma.
Must be in complete remission (CR).
Tests and scans will be required to confirm remission.

Exclusion Criteria:
Patients below the defined minimum of height and weight.
Patients who are currently receiving another study drug may not participate.
Patients who are currently receiving other anticancer agents may not participate.
Children's Health, Cancer
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Hershey, PA ,

Home Observation of Meals and Environment (HOME) Bytes

This study aims to measure child eating behavior at home. Parents will video record their child eat 3 meals at home using a smart phone device and then take pictures of food storage locations (e.g., fridge, pantry). Videos will be coded for child eating behaviors. Parents will complete baseline and follow-up questionnaires. Children will wear an activity watch (like a Fitbit) for 1 week. In addition to these study procedures, there is an optional urine sample collection for children in order to study urinary metabolites as a marker of diet.

You will be asked to video record your child eating 3 meals at home and to take photos of food storage locations in your home (e.g., fridge, pantry).

$75 and an optional $25 for completing the urine sample collection

No
 

Alaina Pearce
Alaina Pearce - at homebytes@psu.edu
Nutritional Sciences (UNIVERSITY PARK)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00023102
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Inclusion Criteria:
Child must be of good health
Child must have no neurodevelopmental disorder (e.g., ADHD) or learning disabilities (e.g., dyslexia)
Child must not be taking any medications known to influence body weight, taste, food intake, behavior, or blood flow.
Child must be 7-10 years-old at enrollment
The child must speak English

Exclusion Criteria:
Child is not within the age requirements (< than 7 years old or > than 10 years-old at baseline).
Child is taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow.
Child has a learning disability, ADD/ADHD, language delays, autism or other neurological or psychological conditions.
Child has a pre-existing medical condition such as type I or type II diabetes, rheumatoid arthritis, Cushing’s syndrome, Down’s syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, or cerebral palsy.
Child has a highly restrictive diet limiting their ability to consume typical meals due to disordered eating (anorexia, RFID) or severe allergies.
Children's Health, Food & Nutrition
Not applicable
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Testing a Biosocial Model of Borderline Personality Features in Youth

In this study, we hope to better understand the neural mechanisms underlying risk for Borderline Personality Disorder (BPD) in adolescent girls. BPD is a condition that is usually found in adults. However, it may be possible to identify risk for the disorder before adulthood. Understanding who is at risk for BPD early in development is important in order to develop preventative interventions.

There will be a total of three visits - one main visit and two follow-ups. Participants will be completing questionnaires, participating in a parent-child observation task, and children will be doing an EEG assessment during the first visit. Participants will be asked to complete questionnaires and participate in a parent-child observation task during the follow-up visits.

$100

Yes
 

Dara Babinski
Dara Babinski - at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285968
Psychiatry and Behavioral Health (HERSHEY)
 

Female
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00018370
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Inclusion Criteria:
Children 10 to 13 year olds
Girls
With or without a current or past history of mental health disorder
Fluent in English

Exclusion Criteria:
Children who are younger than 10 years of age and children who are older than 13 years of age
Diagnosis of intellectual or developmental disabilities (e.g., Autism, Asperger's) , or any psychotic disorders (e.g., schizophrenia, bipolar disorder)
Males
Not fluent in English
Children's Health, Mental & Behavioral Health
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Hershey, PA ,

Insulitis, Inflammation, Dietary intake and Omega-3 Biostatus of Youth with Partial Remission of Type 1 Diabetes

Only 50% of patients with type 1 diabetes (T1D) recover insulin secretion function after 3 months of initial diagnosis, and this phase is called partial remission (PR) of T1D, also called "Honeymoon phase". During this PR phase of T1D, patients recover the ability to secrete more than 50% of their insulin secretion function. This phase of PR typically lasts no longer than 6 or up to12 months, and has been frequently defined as requiring exogenous insulin below 0.5 units per kilogram per day, and hemoglobin A1C is typically below 7.5%. Most recently the use of a coefficient called IDAA1C ≤ 9 has became more accepted as the methodology to determine the development of partial clinical remission of T1D (honeymoon phase). Prior data published by the SEARCH study (national epidemiological study) showed that youth with prolonged honeymoon phase had higher intake of omega -3 fatty acids, vitamin D intake and leucine intake than those youth without prolonged honeymoon phase of T1D. Currently, there are not approved medications to prolong this phase of partial remission of type 1 diabetes, however inducing PR in youth with T1D could potentially decrease the risk of multi-organ damage caused by chronic severe hyperglycemia associated to the chronic hyperglycemia related to T1D.We aim to perform a case- multiple control study between youth with prolonged partial remission phase of T1D after one year of diagnosis, and compare these youths with multiple controls matched by age, gender, race, and puberty stage to study the potential protective factors associated to the development of prolonged partial remission of T1D.

Participants will be approached at their routine Pediatric diabetes clinic appointment. If participants agrees to be in the research, informed consent/assent will be reviewed and signed by all parties. Participant's parent/guardian will be asked to complete a questionnaire. The participant's glucose machine/insulin pump will be downloaded for study purposes. Participant will undergo a fingerstick and a blood draw to collect specific lab values as outlined in the consent.

$35.00

Yes
 

Lina Huerta-Saenz
Erica Miller - at emiller25@pennstatehealth.psu.edu or 717-531-5656
Pediatrics: Endocrinology (HERSHEY)
 

All
Younger than 18 years old
This study is NOT accepting healthy volunteers
STUDY00014114
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Inclusion Criteria:
Type 1 diabetes diagnosis for more than one year
Age 1-17 years old, any gender
Attendance to the Pediatric diabetes clinic at Penn State Health in Hershey, PA
Most recent hemoglobin A1C below 7.5%

Exclusion Criteria:
Age older than 17 years old
History of seafood allergies and/or milk/dairy related allergies
Medical conditions (such as severe cerebral palsy, etc.) that could make patients unable to communicate with the study team
Existence of other autoimmune diseases in addition to T1D requiring regular treatment with immunosuppressive or anti-inflammatory treatment
Diagnosis of type 2 diabetes, monogenic diabetes (MODY), secondary diabetes, pregnancy, compromised kidney function, or liver diseases
Children's Health, Food & Nutrition, Diabetes & Hormones
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Carlisle, PA ,
Harrisburg, PA ,
Hershey, PA ,

Caregiver's Perceptions of High-quality Early Education and Care

This is an exploratory study which looks at how caregivers define high-quality early education and care. Participants will fill out a questionnaire containing open-ended and closed-ended questions. It will take participants no longer than 20 minutes to complete.

No
 

Hannah Mudrick
Hannah Mudrick - at hxm99@psu.edu
Behavioral Sciences and Education (HARRISBURG)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011162
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Inclusion Criteria:
Adults age 18 and older
Adults who are fluent in English
Adults who are regular caregivers of children between birth and age 5
Individuals who can read and respond to written close- and open-ended survey questions electronically
Individuals who live in the United States

Exclusion Criteria:
Individuals under the age of 18
Individuals who are not fluent in English
Individuals who are not regular caregivers of children between birth and age 5
Individuals with poor reading comprehension and are otherwise limited in their ability to read and respond to survey questions
Individuals who do not currently live in the United States of America
Children's Health, Education, Mental & Behavioral Health
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PACE – Development of an Eating Behavior Risk Score

The prevention of obesity is a far more effective approach than treating obesity after it has developed. Researchers and medical providers need better tools to identify risk factors for developing obesity, so families and their physicians can work to reduce a child's risk. This proposed study tests whether a novel risk score (PACE) is good at predicting if children will develop obesity. The PACE Score combines the measures of sensitivity to portion size, behavior while hungry or craving, loss of control during eating, and eating speed. This study will follow children in middle childhood through four visits, followed by two visits one year later. We will identify the components of PACE as well as biological and environmental factors that may work with or against the PACE factors to predict how children's body composition changes over a year.

Four baseline visits followed by two follow-up visits one year laterChildren will be provided meals at each visitChildren and parents will complete questionnairesChildren will have a DXA scan and an MRI scanChildren will play learning games on the computerChildren will wear an activity monitor for one weekChildren will perform brief and moderate exercise while wearing a heart rate monitor

$300

Yes
 

Kathleen Keller
Jonathan Bauman - at jmb7118@psu.edu or 814-753-1005
Nutritional Sciences (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
NCT05073185
STUDY00023903
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Inclusion Criteria:
children must be between the ages of 7-9 years-old at enrollment
The biological mother must have a BMI between 18.5 – 25 or greater than 30. The parent primarily in charge of feeding must be able to accompany children to the visits.
children must speak English fluently
children should have no learning disabilities or developmental delays (e.g., ADHD, Autism, dyslexia)
children generally healthy with a BMI-for-age percentile less than 85 or greater than 95 to be enrolled.

Exclusion Criteria:
If they have a learning disability, ADD/ADHD, language delays, autism or other neurological or psychological conditions.
Child medical condition affecting digestion, cardio, etc.
Child not fluent in English
Child should not be taking a medication that affects blood flow, appetite, behavior, etc.
Child should not have any unremovable metal in their body (e.g. steel dental work) or be claustrophobic
Children's Health, Food & Nutrition, Prevention
Not applicable
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State College, PA ,

Decision-Making in ADHD: An Evaluation of the Subjective Value of Rewards and Costs

Children with attention and behavior problems often need external rewards to motivate them to perform challenging tasks, but we don’t yet know much about how children weigh potential rewards and the effort required to obtain the rewards. This research is being done to find out how children with varying levels of ADHD symptoms value rewards and costs when making decisions about whether or not to perform a difficult task.

There will be one in-person visit. Children will complete two computerized cognitive tasks (thinking games), and will be able to earn prizes from the points they earn on these tasks. Parents will also be asked to complete a few questionnaires that should take about 25 minutes to finish. Children can earn up to $50 in compensation for completing the study.

$50

Yes
 

Dan Waschbusch
Hunter Weidlich - at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285969
Psychiatry and Behavioral Health (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00018076
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Inclusion Criteria:
Children ages 8 to 12 years old
Children with normal or corrected vision
Caregiver and child must be fluent in written and spoken English
Willing to stop stimulant medications, when appropriate, for research testing

Exclusion Criteria:
Children who are younger than 8 years of age and children who are older than 12 years of age.
Current or past diagnosis of autism spectrum disorder, schizophrenia or other psychotic disorders.
Current use of non-stimulant medication due to its extended washout period.
Physical disabilities that are incompatible with completing laboratory tasks such as hearing impairments, or visual impairments that cannot be corrected with visual aids (i.e., glasses, contacts).
Children's Health, Mental & Behavioral Health
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Hershey, PA ,

Saliva microRNA signatures in infants with wheezing associated respiratory illness

Wheezing is a common symptom of respiratory distress in infants and children. Infants who wheeze are at increased risk of being diagnosed with asthma, the most common chronic disease of childhood. This study aims to yield an objective measure of asthma risk using molecular markers obtained from saliva. Saliva miRNA (markers used in this study) levels will be measured using HiSeq technology. Refinement and validation of this measure in future large-scale studies could allow clinicians to accurately predict for families an infant’s risk of asthma and optimize medical management to prevent future hospitalizations.

If your child has a respiratory illness you will be asked to provide a saliva sample at one clinic visit. Six months after the initial encounter, you will be asked to do complete surveys designed to be done remotely at home.

$20.00

Yes
 

Steven Hicks
Courtney Byrnes-Rumbaugh - at cbyrnes@pennstatehealth.psu.edu or 717-531-5656
Pediatrics: General Pediatrics (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00018136
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Inclusion Criteria:
Less than or equal to 12 months of age
Presence of respiratory illness symptoms (cough, congestion, shortness of breath, runny nose)

Exclusion Criteria:
Congenital lower respiratory tract malformation or anomalies
Concurrent pneumonia (bacterial lung infection) at the time of enrollment
Bronchopulmonary dysplasia
Concurrent bacterial infection requiring antibiotics (e.g. otitis media)
Infectious Diseases & Immune System, Children's Health, Allergies
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Hershey, PA ,

One Talk at a Time - Anti-Racism

This is a psychological study to examine the effect of a new intervention that provides parents with tools to speak with their kids about race, racism, and privilege.Participants will complete a 2-3 hour long program and answer questionnaires over the course of 6-8 weeks. The total time required for this study is approximately 4.5 hours for parents and 2 hours for children. Parents can earn up to $165 and children can earn up to $50.

Parents and children will both be asked to participate, and all participation will be remote.Over the course of 6-8 weeks, parents will answer 3 sets of questionnaires in addition to completing 2-3 hour long interactive program. Parents will also be asked to participate in a recorded discussion task with their child, and will be invited back for a short interview as the final task.Children will answer 2 sets of questionnaires at the beginning and end of the study, and will also participate in the recorded discussion task with their parents.

215

No
 

Chardee Galan
Chardee Galan - at dreamlab@psu.edu or 626-205-5563
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00023214
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Inclusion Criteria:
Non-Hispanic, White parent and child
Child between the ages of 10-14 years old
Child in 5th through 8th grade
Parent and youth are fluent in English
Parent and youth have access to devices with WiFi

Exclusion Criteria:
Parent or youth identify as any race/ethnicity other than non-Hispanic White, including multiracial individuals that identify as White
Family does not have reliable internet access or access to a device that can appropriately display the virtual program.
Parent or children does not speak or read sufficient English
Youth or parent/caregiver has an intellectual disability, autism spectrum disorder, or other disorder that may limit ability to complete study (surveys and interviews require sustained attention, mental processing, and comprehension)
Children's Health, Education, Mental & Behavioral Health
Not applicable
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Examining Maternal Reward Responsiveness and the Intergenerational Risk for Depression

Children of depressed mothers are at high risk for developing depression, particularly as youth age into adolescence, yet relatively little is known about the mechanism underlying risk for depression in youth with depressed mothers. The present study examines maternal reward responsiveness, measured across neurophysiological, behavioral, and self-report measures as a marker of depression in mothers of adolescents. Associations between maternal reward responsiveness and parenting difficulties often associated with maternal depression, as well as adolescent functioning will be examined, to explore the clinical impact of maternal reward responsiveness on the intergenerational transmission of depression.

Yes
 

Dahlia Mukherjee
Sarah Shahriar - at sshahriar1@pennstatehealth.psu.edu or 717-531-0003, ext=285189
Psychiatry and Behavioral Health (HERSHEY)
 

All
All
This study is also accepting healthy volunteers
STUDY00009643
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Inclusion Criteria:
Female adults 18 years and above with an adolescent child aged 13-16 years
Capacity for informed consent
Fluent in verbal and written English
Adolescent between the ages of 13 and 16 years (inclusive)

Exclusion Criteria:
Diagnosis of autism spectrum disorder, substance use disorders, schizophrenia or other psychotic disorder
Any hearing or visual impairments
Investigator discretion regarding ability to participate in the study
Children's Health, Mental & Behavioral Health, Women's Health
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Hershey, PA ,

Expanding Family Foundations to 2nd-Time Parenthood - Focus Group

This focus group study, funded by Penn State's Social Science Research Institute, brings together couples with preschool-aged firstborns who are pregnant with their 2nd child or who have given birth to their 2nd child within the last 12 months. Couples will be interviewed about how they worked together as a team (as coparents) to prepare their firstborn for the birth of the second child and to prepare themselves for 2nd-time parenthood.

Yes
 

Douglas Teti
Douglas Teti - at dmt16@psu.edu or 814-863-9570
Human Development and Family Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015968
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Inclusion Criteria:
1.Two-caregiver families, any race or ethnicity, with one or two children: a.One subgroup with one child < 6 years of age and pregnant with a 2nd child b.One subgroup with one child < 6 years of age and an infant between 1-to-12 months of age.
2.Each caregiver is over 18 years of age.
3.Caregivers are living together in the same household and are either married or living with a partner.
4.Families living independent of parents’ families of origin.
5.Both caregivers fluent in communicating in English.

Exclusion Criteria:
1.One or the other caregiver cannot understand or speak English
2.Caregivers are under 18 years of age.
3.Caregivers not living together
4.Caregivers not living independently of their families of origin
5.Single-parent families with no live-in partner.
Children's Health, Prevention, Mental & Behavioral Health
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Altoona, PA ,
Carlisle, PA ,
DuBois, PA ,
Erie, PA ,
Greater Philadelphia Area, PA ,
Greater Pittsburgh Area, PA ,
Harrisburg, PA ,
Hazleton, PA ,
Hershey, PA ,
Mont Alto, PA ,
Reading, PA ,
Schuylkill Haven, PA ,
Sharon, PA ,
State College, PA ,
Wilkes-Barre/Scranton Area, PA ,
Williamsport, PA ,
York, PA ,

Nurse Situation Awareness in ICUs

This is an interview and survey study that will examine how the design of ICU warning information system influence nurses situation awareness.

This study aims to understand how the design factors of warning information system influence nurse situation awareness in ICUs. You will participate an online interview study and fill out two questionnaires. The study takes 1-2 hours.

$30

No
 

Yiqi Zhang
Yiqi Zhang - at yuz450@psu.edu
Industrial and Manufacturing Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020979
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Inclusion Criteria:
Be a practicing nurses or a nursing student who has clinical experience in ICU settings

Exclusion Criteria:
NA
Children's Health, Education, Mental & Behavioral Health
Not applicable
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The Child Health Study

We want to understand how a child's environment affects biology in ways that impact child health

The project involves completing three Penn State ChildHealth Days on the University Park Campus in StateCollege, PA 2 years apart. Your child will receive a comprehensivehealth screening and you will be asked to completeseveral assessments about your child’s physical healthand emotional well-being. Travel and hotel costs arefree for eligible families.

520

Yes
 

Hannah Schreier
Finnley Christine - at childhealthstudy@psu.edu or 888-924-4535
Biobehavioral Health (UNIVERSITY PARK)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00006550
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Inclusion Criteria:
Children 8-13 years of age
Speak and understand English
Participation of a legal guardian

Exclusion Criteria:
Intellectual or learning disability
Children's Health, Food & Nutrition, Education
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State College, PA ,

Central Pennsylvania Rural Birth Cohort

This study is being conducted to understand what strategies are most successful: 1) in building and retaining a cohort of families from rural communities in Central Pennsylvania with recruitment beginning in pregnancy, infant/toddler age, and preschool age using a cohort sequential design; 2) for collecting clinical and semi-invasive, remote-based biobehavioral measurements to better characterize synergistic factors associated with obesity and substance use in this high risk population; and 3) for identifying points for future intervention, treatment, prevention, and policy efforts to reduce health disparities in maternal-child morbidity and promote positive family processes.

Cohort 1 (Pregnancy Cohort) will follow the assessment schedule as described below:Visit 1 will occur around 16-weeks gestation. You will complete online surveys. The surveys should take 1 hour or less.. Visit 2 will occur around 32-weeks gestation. You will complete online surveys, and a semi-structured health behaviors interview via Zoom. You may also be asked to collect hair and/or nail samples. The visit should take 2 hours or less. Visit 3 will occur around 6 months post-delivery. You will complete online surveys. The surveys should take 1 hour or less. Visit 4 will occur around 12 months post-delivery. You will complete online surveys and a parent-child interaction observation (one session). This visit should take 1 hour or less.Cohort 2 (12 month old child Cohort) will follow the assessment schedule as described below:Visit 1 will occur around 12 months post-delivery. You will complete online surveys, and a parent-child interaction observation (one session). You may also be asked to provide hair and/or nail samples. This visit should take 2 hours or less. Visit 2 will occur around 24 months post-delivery. You will complete online surveys. This visit should take 1 hour or less.Cohort 3 (24 month old child Cohort) will follow the assessment schedule as described below:Visit 1 will occur around 24 months post-delivery. You will complete online surveys. You may also be asked to provide hair and/or nail samples. This visit should take 1 hour or less.Visit 2 will occur around 36 months post-delivery. You will complete online surveys. This visit should take 1 hour or less.All electronic health record data will be extracted at the end of study participation.

$100-200

No
 

Danielle Downs
Birth Cohort Team at birthcohort@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00020841
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Inclusion Criteria:
Pregnant person over age of 18 with a singleton pregnancy
Over the age of 18
Families with toddlers that are either 12 or 36 months of age
Live in rural Pennsylvania
Have smartphone/wifi access

Exclusion Criteria:
Not pregnant or multiple pregnancy
Pregnant person or parents under age of 18
Families without toddlers that are either 12 or 36 months of age or a multiple (twin, triple, etc.)
Live outside of rural Pennsylvania
Do not have smartphone/wifi access
Children's Health, Pregnancy & Infertility, Women's Health
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