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Novel Therapies to Improve Cardiac and Skeletal Muscle O2 Supply-Demand Mismatch in Older Adults with Peripheral Arterial Disease: Esmolol infusion

This research is being conducted to determine how oxygen delivery to the heart and leg muscles is altered when beta-1 receptors (receptors involved in the “fight or flight” response) are temporarily blocked through a medication infused into an arm vein (compared to when a simple saline solution is infused). This will help us determine whether the medication, Esmolol, a beta-1 blocker, can eventually be used in the evaluation or treatment of PAD.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
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18 year(s) or older
This study is also accepting healthy volunteers
NCT04181606
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Inclusion Criteria:
Men and women age 21-85 years
Healthy
Not currently taking medications affecting heart rate or contractility
Exclusion Criteria:
Females who are pregnant or lactating
Bleeding or clotting disorder
HIstory of angina or recent heart attack
Diabetes or hypertension
Heart & Vascular
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Location
Hershey, PA