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The role of nuclear factor from activated T-cells (NFAT) in microvascular dysfunction

High blood pressure can lead to cardiovascular disease (CVD). CVD is a leading cause of illness and death in the United States. This research explores some of the ways high blood pressure impairs blood vessel function. This study uses minimum-risk procedures (flow meditated dilation, skin biopsy, and microdialysis) to explore the mechanisms underlying the impaired blood vessel function. We conduct experiments before and after 7-day treatment with FDA-approved drugs Telmisartan (prescribed to treat high blood pressure) and Tacrolimus (prescribed to treat eczema). The results of this study could suggest new ways to diagnose and treat high blood pressure. The expression of NFAT isoforms are altered in essential hypertensive vascular tissue and that short term telmisartan decreases NFAT-mediated cytokine production in hypertensive adults. We predict that 10 days of Telmisartan will alter the expression profiles of NFATc1 and NFATc3 and improve endothelial function and vascular smooth muscle cell responsiveness.
Susan Slimak at sks31@psu.edu
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18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Men and women, 18-70 years of age
Normal or high blood pressure
Non-obese, BMI ≤ 39.9
Normal HbA1C of <6.5%
Not pregnant or breastfeeding
Exclusion Criteria:
Rash, skin disease, disorders of pigmentation
Diabetes, kidney, liver disease
Taking heart and blood pressure drugs
Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
Low blood pressure, < 90/60 mmHg
Heart & Vascular
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Location
State College, PA