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Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

1 Study Matches

Site for A 2-Part Seamless Part A (phase 2)/Part B (Phase 3) Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of BIIB059 in Participants with Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus with or without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)

SLE/CLE Lupus: 18 years and older; SC (subcutaneous injection) every 4 weeks with an additional dose given at Week 2 and Week 26. Randomization is 2:1 BIIB059 to placebo (non active ingredient); 52 weeks of treatment. There are 2 parts to the study, Part A and Part B. The goal of Part A is to confirm the adequacy of an investigator specific evaluation. The goal of Part B is to demonstrate the efficacy and safety of BIIB059 compared with placebo.

You will attend 21 visits and have 2 phone calls over approximately 52 weeks. At different time points throughout the study you will have photographs taken of your lesions, labs drawn, an ECG performed, skin examinations, a chest x-ray, you will need to complete questions, and fill out a diary.

Joslyn Kirby
Amy Longenecker - at or 717-531-5136

18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Confirmed CLE diagnosis
Previous use and failure of antimalarial agents; study coordinator will discuss further

Exclusion Criteria:
History or positive test result at Screening for HIV; Current hepatitis B or C infection
Certain medications not allowed; study coordinator will discuss
Certain medical history may be excluded from participation; study coordinator will discuss
Skin Conditions
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Location Contacts
Hershey, PA ,