Examining elderly traumatic brain injury and risk for neurodegeneration
The purpose of this proposal is to understand the risk factors for Alzheimer’s disease after TBI, including time since diagnosis, ethnicity, and genetic predictors. In Aim 1 the goal is to collect data in a large group of individuals with TBI to understand these interacting factors in predicting cognitive decline. Then in Aim 2, in a sub-group of individuals we use brain imaging methods in order to determine the network response associated with neurodegeneration decades post TBI. Ultimately, the ability to monitor the neural network response to injury-specific factors in combination with risk/resiliency factors (e.g., genetic, health) may bring greater precision to rehabilitation in TBI and aid in identifying patients at risk for neurodegeneration years prior to onset. Three specific aims were designed to clarify the role of neural recruitment in recovery from TBI:
There will be one in person visit that lasts ~5 hours. It involves an MRI scan, blood pressure measurement, cognitive testing, and interviews about social and emotional wellbeing.
sustained a traumatic brain injury
history of neurological disorder such as stroke, epilepsy, or multiple sclerosis
history of bipolar