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1 Study Matches

Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

For this study, 75 smokers will be randomly assigned to smoke research cigarettes with a very low or normal nicotine content. Participants will complete functional magnetic resonance imaging (MRI) scans at 2 in-person study visits to help us better understand how reducing nicotine intake affects decision making and reward processing.

There will be 2 in-person visits that require the following at each visit: MRI scan, saliva and urine samples. There are 2 remote visits conducted over Zoom. Subjects will be randomly assigned research cigarettes that will replace their normal cigarettes for 6 weeks between their 2 MRI scans. There will be surveys to complete and daily smoking logs to keep.


Andrea Hobkirk 717-531-5473

18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Smoke greater than or equal to 5 cigarettes per day
21-60 years old
>1 year daily smoking
Live local for next 3 months
No plans to quit smoking in next 6 mos.

Exclusion Criteria:
Regular use of non-cigarette tobacco products
MRI safety contraindications
Unstable or significant medical conditions
smell dysfunction
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse
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Location Contacts
Hershey, PA ,