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Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

1 Study Matches

A double-blind randomized placebo-controlled study on the analgesic properties of amiloride in exercise-induced skeletal muscle pain

To determine if the drug Amiloride will reduce exercise related muscle pain and improve exercise tolerance in healthy volunteers.

In each visit, you will be asked to perform foot exercise with, and without a blood pressure cuff inflated on your leg. You will also be asked to take pills prior to visit 2 and 3. One of these pills will be a drug called amiloride (10mg), which was traditionally used to lower blood pressure. The other pill will be a placebo (no active medication). During each visit, we will collect the following measurements: • We will collect a nerve recording from the leg not performing exercise, which will require a small needle-like electrode to be inserted behind your knee, just under the skin (a procedure called microneurography). • We will collect blood pressure from cuffs placed on your finger and upper arm. • We will collect blood lactate by sticking your finger with a small pin-prick (similar to taking a blood sugar measurement). • We will place to light-sensing device over the skin of your leg(s) to measure the oxygen level in your muscle. • We will hold a doppler ultrasound probe over your hip/leg region to measure blood flow. • We will use sticky-gel electrodes to measure heart rate and muscle activity.

You will receive $25 per hour for your participation in this research study

Jian Cui
Aimee Cauffman - at or 717-531-1617

18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
healthy males and females
between 21-40 years old
any race or ethnicity

Exclusion Criteria:
Females who are pregnant or lactating
high blood pressure
opiod use
taking amiloride or similar medication
Heart & Vascular
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Location Contacts
Hershey, PA ,