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Assessment of nocturnal hypoventilation in amyotrophic lateral sclerosis

The overall goals of this study are to identify how measurement of carbon dioxide during sleep can improve recognition of respiratory distress in neuromuscular disease and thus improve timely access to respiratory therapies which prolong survival. Subjects in this study will participate for up to one year, during which their carbon dioxide levels will be measured in clinic and in their homes during sleep.

Subjects in this study will participate for up to one year, during which their carbon dioxide levels will be measured using deviced attached to the skin while in clinic and in their homes during sleep. Subjects will also complete surveys at the time of clinic visits.

50

Andrew Geronimo
Andrew Geronimo - at ageronimo@pennstatehealth.psu.edu
 

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18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00017603
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Inclusion Criteria:
Diagnosis of amyotrophic lateral sclerosis
18 years of age or older.
Plan to be followed up in person in the Hershey ALS Clinic for the next 12 months.
Experiencing early respiratory change.
Able to perform or have assistance performing home CO2 measurements.
Exclusion Criteria:
In hospice or in active transition to hospice
Use of any type of non-invasive ventilation, except in the case of CPAP for obstructive sleep apnea, or have a tracheostomy
Use of diaphragm pacer
Pre-existing pulmonary disease requiring supplemental oxygen for any portion of the day or night
Neurology
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Hershey, PA ,