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1 Study Matches

Efficacy and safety investigation of NNC0194-0499 co-administered with semaglutide in subjects with non-alcoholic steatohepatitis: a dose-ranging, placebo-controlled trial

Currently, no drugs are globally approved for the treatment of non-alcoholic steatohepatitis (NASH). First-line of treatment is lifestyle intervention to achieve weight loss. Combination treatment with multiple drugs may be more effective. This trial will assess the safety and efficacy of three doses of NNC0194-0499 (the study drug) in combination with semaglutide versus placebo in the treatment of NASH.
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Aged ≥ 18 years at the time of signing informed consent
Evidence of NASH based on a liver biopsy
Stage 2, 3 or 4 of fibrosis
non-alcoholic fatty liver disease (NAFLD) activity score (NAS) ≥ 4
Exclusion Criteria:
causes of chronic liver disease other than NAFLD
Treatment with vitamin E
alcohol dependence
Digestive Systems & Liver Disease
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Hershey, PA