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Effects of acid sensing ion channels blockade with amiloride on exercise pressor reflex in patients with peripheral artery disease
The purpose of the study is to determine the effects of amiloride on the blood pressure response during exercise, and exercise tolerance in patients with PAD and healthy controls.
There will be 3 in-person visits. You will take a capsule of amiloride or placebo before visits 2 and 3 and blood pressure, heart rate and other physiological measurements will be recorded.
You will receive $25 per hour for your participation in this research study
Yes
Cheryl Blaha - at cblaha@pennstatehealth.psu.edu or 717-531-1605
Heart and Vascular Institute (HERSHEY)
All
18 year(s) or older
STUDY00018295
Inclusion Criteria:
Men and women age 21- 85 years Any race or ethnicity
Healthy: Free of acute medical conditions
PAD: Diagnosis of PAD, no pain at rest
Exclusion Criteria:
Pregnant or nursing womenResting blood pressure of 150/100 or higher
Already taking amiloride
Recent heart attack or epilepsy
Peripheral neuropathy
Men's Health, Heart & Vascular, Women's Health