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Effects of acid sensing ion channels blockade with amiloride on exercise pressor reflex in patients with peripheral artery disease
The purpose of the study is to determine the effects of amiloride on the blood pressure response during exercise, and exercise tolerance in patients with PAD and healthy controls.
Cheryl Blaha - at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
STUDY00018295
Inclusion Criteria:
Men and women age 21- 85 years Any race or ethnicity
Healthy: Free of acute medical conditions
PAD: Diagnosis of PAD, no pain at rest
Exclusion Criteria:
Pregnant or nursing womenResting blood pressure of 150/100 or higher
Already taking amiloride
Recent heart attack or epilepsy
Peripheral neuropathy
Men's Health, Heart & Vascular, Women's Health