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Women In Steady Exercise Research - Window of Opportunity for Exercise and Tumor Biology

The aim of the study is to test how an increase in the heart rate can interact with cancer. The study population is newly diagnosed breast cancer patients. The study intervention is an acute exercise test. The primary outcome of the study is imaging of the tumor before, and in a time course after, the acute exercise test.

The study is one single visit that lasts for about 3 hours. We will ask participants to fill out a few short questionnaires. Participants will be asked to walk or jog on a treadmill for as long as they can. We will collect blood samples via an IV line 1) before the acute exercise, 2) immediately after the exercise, 3) 30 min after the exercise, and 4) 2 hours after the exercise. Also, we will use an ultrasound machine to image breast and tumor 1) before the acute exercise, 2) immediately after the exercise, 3) 30 min after the exercise, and 4) 2 hours after the exercise.

100

Kathleen Sturgeon
Kathleen Sturgeon - at kms99@psu.edu
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05428709
STUDY00019979
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Inclusion Criteria:
Newly diagnosed breast cancer patients
Breast tumor is more than 2 cm (T2)
No initiation of chemotherapy treatment
Pre-surgical breast resection
With or without lymph node involvement (N0-3)

Exclusion Criteria:
Current use of blood-thinners
Body weight <100 lbs
Started chemotherapy for breast cancer
Absolute contraindications for exercise stress testing by self-report, such as acute myocarditis or pericarditis, uncontrolled heart failure
Pregnant women
Cancer
Not applicable
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See this study on ClinicalTrials.gov
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Study Locations

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Location Contacts
Hershey, PA ,