Women In Steady Exercise Research - Window of Opportunity for Exercise and Tumor Biology
The aim of the study is to test how an increase in the heart rate can interact with cancer. The study population is newly diagnosed breast cancer patients. The study intervention is an acute exercise test. The primary outcome of the study is imaging of the tumor before, and in a time course after, the acute exercise test.
The study is one single visit that lasts for about 3 hours. We will ask participants to fill out a few short questionnaires. Participants will be asked to walk or jog on a treadmill for as long as they can. We will collect blood samples via an IV line 1) before the acute exercise, 2) immediately after the exercise, 3) 30 min after the exercise, and 4) 2 hours after the exercise. Also, we will use an ultrasound machine to image breast and tumor 1) before the acute exercise, 2) immediately after the exercise, 3) 30 min after the exercise, and 4) 2 hours after the exercise.
Breast tumor is more than 2 cm (T2)
No initiation of chemotherapy treatment
Pre-surgical breast resection
With or without lymph node involvement (N0-3)
Body weight <100 lbs
Started chemotherapy for breast cancer
Absolute contraindications for exercise stress testing by self-report, such as acute myocarditis or pericarditis, uncontrolled heart failure