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Effects of acid sensing ion channels blockade on the exercise pressor reflex following ischemia-reperfusion stress in healthy individuals
The purpose of this voluntary research study is to test if the drug amiloride can decrease blood pressure during exercise.
This project includes 3 visits to the research lab. Each visit last approximately 3.5-4 hours (~11-12 hours altogether). In each visit, you will be asked to perform foot exercise before and after a blood pressure cuff on your leg was inflated. You will also be asked to take pills prior to visit 2 and 3. One of these pills will be a drug called amiloride (10mg), which was traditionally used to lower blood pressure. The other pill will be a placebo (no active medication).
You will receive $25 per hour for your participation in this research study
Yes
Cheryl Blaha - at cblaha@pennstatehealth.psu.edu or 717-531-1605
Heart and Vascular Institute (HERSHEY)
All
18 year(s) or older
STUDY00021886
Inclusion Criteria:
Men and women of any race or ethnicity21-40 years of age
Healthy (absence of any active or chronic disease)
Exclusion Criteria:
Are not between 21-40 years oldPregnant or nursing women
Have a major disease (heart, lungs, kidney, diabetes, cancer)
current smoker
High blood pressure
Heart & Vascular
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