In today’s climate of anti-Asian hate, we believe that it is important to uncover different aspects of what “being Chinese” could look like. To this end, we are looking for individuals who self-identify as ethnically Chinese, woman, and a member of the LGBTQIA+ community to participate in a one-time 90-minute online interview to learn about what they do in their regular, everyday life to try to show or tell others about who they are. As part of the study, we will ask interviewees to share some visual images (e.g., photos, drawings, etc.) that they own as a way of elaborating on the ways that they communicate their self-identity in everyday life.

The purpose of this study is to compare any good and bad effects of using stereotactic body radiation therapy (SBRT), a technique that gives treatment in a shorter amount of time compared to the usual radiation therapy. SBRT is experimental for treating this type of cancer. SBRT uses special equipment to position a participant and precisely deliver radiation to tumors in the body. Both the study and the usual radiation treatments use daily images to guide the radiation treatment to protect normal tissue. The study treatment, treatment over a shorter amount of time, may prevent the tumor from returning but it could also cause side effects. This study will allow the researchers to know whether this different approach using SBRT is better, the same, or worse than the usual approach. To be better, the study treatment should increase the time without the cancer coming back by six months or more compared to the usual approach, and show improvements in side effects to the bladder or rectum.

The purpose of this study is to compare any good and bad effects of using stereotactic body radiation therapy (SBRT), a technique that gives treatment in a shorter amount of time compared to the usual radiation therapy. SBRT is experimental for treating this type of cancer. SBRT uses special equipment to position a participant and precisely deliver radiation to tumors in the body. Both the study and the usual radiation treatments use daily images to guide the radiation treatment to protect normal tissue. The study treatment, treatment over a shorter amount of time, may prevent the tumor from returning but it could also cause side effects. This study will allow the researchers to know whether this different approach using SBRT is better, the same, or worse than the usual approach. To be better, the study treatment should increase the time without the cancer coming back by six months or more compared to the usual approach, and show improvements in side effects to the bladder or rectum.

The purpose of this study is (1) to understand how the brain processes sensory information and (2) how this is affected by factors like blindness or synesthesia. In addition to behavioral testing, the study will use functional magnetic resonance imaging (fMRI) which enables us to take pictures of the brain while you are doing a task, using an instrument called an MRI scanner.

Participants will perform simple behavioral tasks either stand-alone or while being scanned; they may also complete questionnaires or rating scales.

Amount varies depending on the study

The purpose of this Phase III study is to compare Overall Survival (OS) and Recurrence Free Survival (RFS) across the two arms: MK3475 (Pembrolizumab) to Standard of Care Observation. Patients will undergo standard clinical procedures including physical, labs, vitals, ecg's, and imaging.

We are asking you to take part in a research study. We do research studies to try to answer questions about how to prevent, diagnose, and treat diseases like cancer.

The purpose of this proposal is to understand the risk factors for Alzheimer’s disease after TBI, including time since diagnosis, ethnicity, and genetic predictors. In Aim 1 the goal is to collect data in a large group of individuals with TBI to understand these interacting factors in predicting cognitive decline. Then in Aim 2, in a sub-group of individuals we use brain imaging methods in order to determine the network response associated with neurodegeneration decades post TBI. Ultimately, the ability to monitor the neural network response to injury-specific factors in combination with risk/resiliency factors (e.g., genetic, health) may bring greater precision to rehabilitation in TBI and aid in identifying patients at risk for neurodegeneration years prior to onset. Three specific aims were designed to clarify the role of neural recruitment in recovery from TBI: 



There will be one in person visit that lasts ~5 hours. It involves an MRI scan, blood pressure measurement, cognitive testing, and interviews about social and emotional wellbeing.

$150

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.

There will be three in person visits for this study. At the screening visit, participants will undergo a detailed medical history and physical examination and then will complete a mental test while lying down and standing. If eligible based on the results of the mental test, participants will undergo a pregnancy test if female and of childbearing potential, measurements of blood pressure and heart rate and blood draws while lying down and standing up, and a test to determine if they can tolerate being in a lower body negative pressure (LBNP) device that distributes more blood to the legs to mimic standing. If eligible based on the results of the screening visit, participants will be asked to complete an online questionnaire and two study visits that are separated by at least one week. At these study visits, they will perform a mental test in a magnetic resonance imaging (MRI) scanner. The LBNP device will also be used while in the MRI scanner to distribute more blood to the legs to mimic standing.

$25 per hour; additional $25 for completion of online questionnaire

Tobacco users will be randomized to use electronic cigarettes containing varying levels of nicotine and flavor during laboratory protocols to investigate the effects on the brain and behavior. Subjects will complete surveys, functional magnetic resonance imaging scans, and complete computerized tasks. Eligible participants include daily users of inhaled tobacco products who are at least 21 years old, able to read and write in English, and not planning to quit tobacco use within the next month. Exclusion criteria include: current substance use impairing participation, unstable or significant medical conditions, current use of smoking cessation medication, uncontrolled serious mental illness, and MRI safety or neurological contraindications.

Subjects will taste test a variety of e-cigarette flavorings, answer questions and complete a single MRI.

50

The purpose of this research is to take and store blood, urine samples from pregnant women diagnosed by a positive pregnancy test or by ultrasound imaging. The purpose of this study is to determine a better way to diagnose the location and/or viability (chance of survival) of a pregnancy, as compared to current clinical care. Many women are found to be pregnant by a hCG (human chorionic gonadotropin) test which detects a hormone that is indicative of pregnancy. However, in early pregnancy, it is often difficult to see the pregnancy by ultrasound, which is called a pregnancy of unknown location (PUL). In early pregnancy, doctors do many tests (including blood tests and ultrasounds) to try to determine how far along the pregnancy is, whether it is healthy, and most importantly whether the pregnancy is growing in the right place. The doctors running this research project are trying to see if there are substances (biomarkers) in the blood or urine of a pregnant woman that can tell whether the pregnancy is a normal, healthy pregnancy, an ectopic pregnancy, or if pregnancy is not viable (miscarriage). To do this, blood and/or urine samples are being collected from women who have a pregnancy of unknown location, an ectopic pregnancy, women who are having a miscarriage, and women with a healthy growing pregnancy. The study will then look at a pre- determined panel of biomarkers that have been shown to be elevated (higher) or decreased (lower) in different types of pregnancy to determine the effectiveness and accuracy of this test in earlier diagnosing the viability and location of early pregnancy.

There will be one visit at the visit participants will be consented and following consenting blood and urine will be collected.

$25.00

The purpose of this study is to investigate how language is organized in neurologically normal adults using magnetic resonance imaging (MRI) and behavioral measures. Our overarching goal is to characterize the behavioral and MRI responses associated with language production and language comprehension in older and younger adults, and to examine the relations between age, behavior, cognition, and neural factors.

Participants will complete a remote visit and two in person visits at the University park campus. Visit activities will include answering questions, completing computer-based tasks, and completing an MRI scan.

$100

Rates of obesity have risen sharply throughout the world over the past several decades. The increase in the availability of highly palatable, high-calorie foods may be one factor that has contributed to this trend. That is, the availability of such foods may lead to their over-consumption and corresponding weight gain. Currently, relatively little is known about how the availability of foods, per se, affects things such as the motivation to eat and the ability to resist doing so. The current study is designed to help address this knowledge gap by examining the effects of food availability in people with high levels of dietary restraint. Dietary restraint, which refers to the intention to restrict food intake deliberately in order to prevent weight gain or to promote weight, is linked to problematic patterns of eating. This project uses laboratory tasks and brain imaging to study the effects of food availability on various outcomes, including food choices, food craving, and responses in brain areas linked to motivation.

Participants will be asked to fill out some online questionnaires and complete some computerized behavioral tasks. They will be asked to attend a one-hour virtual screening/baseline session via Zoom, and a 3-hour MRI session in the Penn State campus, University Park. In the MRI session, participants will be performing on a task involving asking them to view a series of colorful food pictures inside an MRI scanner while their brain activity is being scanned.

80

This study is being done to answer the following question:Can tomosynthesis mammography, three-dimensional x-ray imaging of the breast, lower your chance of developing life-threatening breast cancer through routine screening compared with digital mammography, two-dimensional x-ray imaging of the breast?We are doing this study because we want to find out which of the two usual approaches to breast cancer screening are better in the early detection of life-threatening breast cancers.

The goal of this study is to measure emotional and brain responses related to the motivation to smoke cigarettes. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. The study also involves measuring moment-to-moment changes in emotion by coding facial expressions. A primary goal of the project is to examine how changes in brain activity are related to changes in emotion over time. If successful, the project will help to demonstrate the usefulness of combining fMRI and facial coding to study cigarette smoking and other harmful behaviors.

There will be two in-person visits. Brain imaging scans (using functional magnetic resonance imaging) will be completed at one of these visits.

100

The goal of this research is to understand the role of motion-processing areas on limb motor control. We will be using behavioral studies and combining that with functional brain imaging, EEG, and non-invasive brain stimulation using transcranial magnetic stimulation (TMS). TMS has been used in thousands of studies and is a very safe method to understand brain function for eye hand coordination.

There will be three visits. Participants will under go brain scanning. They will perform eye-hand coordination tasks by grabbing a robotic manipulandum. During the eye-hand coordination tasks, participants' brain activity will be measured using electroencephalography (EEG) and muscle activity using surface electromyography (EMG). Researchers will also apply transcranial magnetic stimulation (TMS) to temporarily inhibit and excite different brain areas. TMS is a noninvasive procedure that uses magnetic fields to stimulate nerve cells

50

The purpose of the study is to test how social decisions are affected by possible risk of infection. We aim to examine how choices in a risky social decision-making situation can influenced by viewing images of infection threat (e.g., person with runny nose) vs. images of neutral scenes or other threatening scenes.

There will be one 90-minute in-person visit. Participants will be asked to have electrodes placed on their skin to record their physiological signals, answer questionnaires, and complete a decision-making task on the computer while looking at different images.

$30

The purpose of this voluntary research study is to find out more about changes in the brain as we age. This study is trying to determine if magnetic resonance imaging (MRI), genetic variations, amyloid positron emissions tomography (PET), neuropsychological testing, and smell tests can be used to evaluate memory loss and cognitive impairment.

You will be asked to come to the research site once a year for 5 years.Annual (and semi-annual) procedures include completing smell tests, neuropsychological tests, magnetic resonance imaging (MRI). One-time procedures include provide blood sample, amyloid PET scan (if indicated), and optional lumbar puncture.

Up to $250 a year

A study looking at the neural and genetic correlates of depression. Presently, the current study is looking to recruit individuals for two separate groups: 1. MS but NO history of depression2. Depression but NO history of MS or neurological disease. The purpose of the study is to look at patterns of brain structure and function in individuals with depression and compare them to those with MS. We will explore how any differences we find contribute to more problems with depression in MS and see how such differences might lead to better treatment options for depression.

Heart disease is the leading cause of death in the United States. The loss of estrogen from menopause puts women at a greater risk of developing heart disease. The purpose of this study is to determine the effects of drinking beetroot juice on measures of blood vessel health and blood pressure. Participants will drink beetroot juice and placebo juice each for one week followed by blood pressure measurements and ultrasound imaging of an artery in the upper arm. A sub-aim of this study is to investigate the effects of estrogen status on blood vessel function between pre- and post-menopausal women.

There are a total of 6 in-person visits to the Clinical Research Center. You will be asked to drink beetroot juice (2 oz) every day for 7 days. Participants will undergo vascular assessments, blood pressure measurements, and blood draws (11 in total for 6 visits).

$120

This research is being done to find out the relationship between an individual’s mental state and how well they perform visual-perceptual tasks. This will allow us to understand the brain processes related to errors in image perception, to understand how mental states impact medical image interpretation. Overall, this research will help us develop training programs to reduce the amount of perceptual errors in diagnosing images

The goal of this study is to learn more about how people who smokecigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.

We are interested in what adults notice about stimuli that are presented to them. These stimuli typically consist of novel objects, abstract images, or made-up words.

This study aims to evaluate the effect of providing one avocado per day for consumption over a six month period on established health parameters, including visceral adiposity, hepatic lipid content, markers of metabolic syndrome and high sensitivity C-reactive protein (hsCRP), compared to habitual diet.The primary aim of this study is to determine whether providing one avocado per day for consumption for six months will produce a greater decrease in visceral adiposity as measured by magnetic resonance imaging (MRI) in Americans with an increased waist circumference as compared to habitual diet.

The purpose of this study is to see if neck and shoulder function and pain are better after SLN biopsy surgery compared to the usual approach and to see if SLN biopsy surgery is as good as the usual approach in extending your time without cancer. SLN biopsy surgery is potentially less invasive compared to the usual approach, but it requires a radioactive imaging agent to see the lymph nodes and it could also cause side effects. These side effects are described in the risks section below. Your study doctor will choose the appropriate imaging agent, Lymphoseek or sulfur colloid, for use in your surgery.This study will help the study doctors find out if this different approach is better than the usual approach at improving neck and shoulder function. To decide if it is better, in the first part of the study, doctors will be looking to see if shoulder and neck function and quality of life are better after SLN biopsy surgery compared to the END surgery.

We are asking you to take part in a research study. This study has public funding from the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) in the United States Department of Health and Human Services. We do research studies to try to answer questions about how to prevent, diagnose, and treat diseases like cancer. We are asking you to take part in this research study because you have early-stage oral cavity cancer and are having neck dissection surgery.

The objective of this study is to compare to different methods of measuring the size of calf muscles: magnetic resonance (MRI) and ultrasound imaging. Participant will undergo a MRI scan (about 1 hour) and an ultrasound imaging session (about 1 hour). Images obtained from patients with Achilles tendon rupture will also be used to determine the feasibility of quantifying damage to the soleus muscle.

After you accept participating demographic questions will be asked. You will also be asked standard MRI safety/screening questions. These questions are used to determine that it is safe for you to participate in MRI research. You will be asked to leave metal objects and personal belongings and to remove any articles of clothing with metal before entering the MRI room. Please ask the experimenter if you are unsure about any items. If it is safe, an MRI will be performed on your leg. Additionally, several images will be taken from your leg using ultrasound. The ultrasound and MRI sessions can be performed the same day or in different days depending on your preference. Depending on scheduling constraints at the MRI facility, you may be scheduled for the ultrasound session first.

You will receive $25 after completing the MRI and $25 after completing the ultrasound imaging sessions.

This study seeks to verify the findings of the CHARM I pilot study by conducting a multi-center clinical trial. We hypothesize that:•Pancreatic cyst infusion with a specifically designed drug therapy cocktail following normal saline lavage will result in cyst destruction rates that do not significantly differ from those achieved by alcohol-based cyst treatment (ethanol lavage followed by infusion of the same chemotherapeutic cocktail).•The removal of alcohol from the procedure will decrease both serious and minor adverse event rates associated with pancreatic cyst treatment.•There may be molecular markers contained within the fluid of these cystic tumors which identify cysts that are favorable to or resistant to EUS-guided fine needle infusion using this drug combination. As such, we will test all treated cysts for 10 of the best known molecular markers for evaluation in post study analysis. We expect that administering a specifically designed chemotherapeutic cocktail without prior alcohol lavage will result in an equivalent rate of cyst resolution with fewer complications when compared to alcohol. The results of this study will provide important information about the most efficient and safest method for treating premalignant pancreatic cysts, an important step for treating these lesions with a minimally invasive technique and preventing their progression to cancer. Standard alternative treatment options for this patient group (if not taking part in this study) would be ongoing periodic radiographic monitoring with MR or CT imaging waiting for signs of cancer to develop or to consider surgical removal of the affected tissue.

Patients will have to sign the consent form to participate in the trial

The purpose of this study is to test the performance of a web-based system for automated review of MRI images across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Participants will attend two study visits that will include questionnaires, a physical exam and motor exams and an MRI (during one of the visits).

300

The purpose of this study is to gather information about what family mealtimes look like for families with children between the ages of 3 and 8. Families will be asked to video record their family mealtime, in addition to answer some questions and to complete some questionnaires, some about body image and dieting.

On one occasion, your family's mealtime will be recorded via Zoom. You and your family will be asked some questions and to complete some questionnaires online.

$20

Prior to enrollment, potential subjects will be evaluated during the Screening Period to determine eligibility. The following assessments will be performed during the Screening Period:●Review of eligibility ●Placement of hydrogel spacer and fiducial marker after eligibility is determined Visit 2 or Day 2 or Post-test - Radiotherapy per standard of care.

Prior to enrollment, potential subjects will be evaluated during the Screening Period to determine eligibility. The following assessments will be performed during the Screening Period:●Review of eligibility ●Placement of hydrogel spacer and fiducial marker after eligibility is determinedVisit 2 or Day 2 or Post-test - radiotherapy per standard of care

This is a drug study that will evaluate how well the investigational drug works compared to a placebo following CAR-T cell therapy. Participants will be required to keep all your scheduled visits, receive drug treatment, blood draws, imaging, and possibly a tumor biopsy.

Participants will be required to receive the study treatments including CAR-T infusion, blook tests, imaging, tumor biopsy, and study medications.

Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to reflect relevant mental processes as they change over time. However, methodological issues have hindered the ability to capitalize on this potential and prevented an understanding of how brain activity and corresponding psychological processes unfold in the critical moments that immediately precede a smoking lapse. The proposed project will address this knowledge gap using a novel fMRI paradigm adapted from a well-validated behavioral lapse task. The goals of the project are to characterize changes in brain activity that lead up to a lapse and to investigate how these changes are related to concurrent affect and subsequent cigarette use.

There will be two in-person visits, both will involve completion of computerized questionnaires and one will involve completing and MRI scan

175

The purpose of this voluntary research study is to evaluate potential new anticancer to treat people with tumors similar to yours. This study will provide information about the safety, the ability of your body to accept the study drug(s), the amount of study drug(s) and/or break-down products in your blood, and your body’s reaction to the study drug(s). Participants will be required to take study medication, have blood drawn, and have imaging tests such as CT, MRI, ECG, MUGA, ECHO, and bone scans.

Participants in the expansion stage will receive study treatment, imaging exams (ECHO, MUGA, ECG, CT, MRI, bone scans), blood draws, tumor assessments, and tumor tissue samples.