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Study matches: 152

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Natural History Study of the Development of Type 1 Diabetes

Natural History Study of the Development of Type 1 Diabetes
Patricia Carper at pcarper@pennstatehealth.psu.edu or 717-531-5656
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
aged 1-45 years and a sibling, offspring, or parent of an individual with type 1 diabetes
aged 1-20 years and a niece, nephew, aunt, uncle, grandchild, cousin, or half sibling of an individual with Type 1 diabetes
willing to have blood drawn
Exclusion Criteria:
Have previous or current use of medications for the control of hyperglycemia
Currently use immunosuppressive or immunomodulatory therapies
Has diabetes
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NCT00097292
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Location
Hershey, PA

Cognitive Processes in Bilinguals: ERP Studies

In this study, we examine how people read words and sentences in their first language or in their second language (if they speak or are learning a second language). We use behavioral (e.g., button presses or recording people's eye movements) or neuroscience methods (e.g., recording of brain waves using electrodes) to collect our data. Participants receive monetary compensation for their participation. I hope you contact us to participate!
Paola Dussias at pdussias@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Adults 18 years or older
Right handed
Normal or corrected-to-normal vision
No history of neurological disorders or language disorders
Participants will be recruited from the following language groups: monolingual English speakers; bilinguals whose native language is English; native speakers of Spanish whose second language is English
Exclusion Criteria:
Children under the age of 18
Left handed or ambidextrous
Uncorrected vision
A history of neurological disorders or language disorders
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N/A
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Location
State College, PA

Establishing a Normal Database for Comparison to Specialized Populations; Oxygen consumption

This study located in Hershey, PA, will examine the cardiovascular and respiratory responses to exercise testing on a treadmill, stationary bike or arm bike to determine overall aerobic fitness capacity. This will contribute to a database of healthy adults to compare to persons with disabilities.
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy Adults
Age 18-75
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Current orthopedic injuries
Claustrophobia
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N/A
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Location
Hershey, PA

PIRE II (Translating cognitive and brain science research to the field and education settings): How Children and Adults Understand Sentences

The focus of the research being conducted asks how bilingual Spanish-English children who are growing up in a Spanish-speaking environment (Granada) but who attend a private school in which they are instructed solely in English, process syntactic ambiguity in Spanish and English. The study is motivated by two questions that the parents of these children have concerning their children’s language development. These are: (1) Whether their children are learning to process English natively; and (2) What effect learning English has on the children’s ability to process Spanish. In this respect, the results have the potential to inform decisions about bilingual education ( translation al implication). In addition to testing bilingual Spanish-English children in Granada, we will also test: bilingual Spanish-English children in the US; bilingual Spanish-English adults in the US; bilingual Spanish-English adults in Spain; monolingual Spanish adults; monolingual English adults; monolingual Spanish children; monolingual English children to serve as our control groups.
Paola Dussias at pdussias@psu.edu
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
Monolingual adults whose native language is English OR Spanish-English bilingual adults
Be 18 years or older (adults)
Have normal to corrected vision
Monolingual children whose native language is English OR Spanish-English bilingual children
Be between 4-14 years old (children)
Exclusion Criteria:
Children who are not monolingual native English speakers or who are not Spanish-English bilinguals
Children outside of the target age range
Adults who are under the age of 18
Children who are not typically developing
Monolingual adults whose native language is not English or adults who are not Spanish-English bilingual speakers
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N/A
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Study Locations

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Location
State College, PA

Parental Stress and Coping Post-NICU Discharge: Perceptions of Daily Stress and Psychobiological Patterns of Response to Stress Challenge

Parental stress levels following discharge from the neonatal intensive unit (NICU) can have impacts on mental health and relationship functioning. The current practice and understanding of Family-centered NICU care often does not address interventions to facilitate parental means to cope with this stress, be it through religious/spiritual means or traditional forms of coping, both of which are tied to their babies’ functioning outside of the NICU. Thus, parental experiences of stress as assessed through self-perceptions and biological and behavioral indicators of stress and coping strategies is an important first-step in future development of a psychospiritual intervention, which is thus far lacking in family-centered NICU care.  
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Parent of a former preterm infant hospitalized in NICU within the past 12 months with parental custody of the infant
Fluent in written and spoken English
Exclusion Criteria:
Chronic illness impacting cardiovascular or autonomic stress measurement (autoimmune disorders- e.g., Lupus, RA, Crohn’s disease)
Advanced cardiovascular disease (e.g., CHD, CHF, arrhythmia, pacemaker, history of MI)
Individuals with endocrine disorders impacting stress hormonal measures (e.g., Cushing’s Disease, Addison’s Disease, IDDM)
Mental illness (e.g., schizophrenia, psychosis, panic disorder)
Pregnant women
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N/A
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Study Locations

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Location
Hershey, PA

Improving Autism Screening with Brain-Related miRNA

The central aim of this project is to characterize the expression of exosomal microRNA (miRNA) in children with autism spectrum disorder (ASD). We propose to measure the expression of extracellular miRNA in children with ASD. Expression levels of miRNA from blood and saliva will be compared between children with autism and normally developing controls. The goal of this study will be to identify genetic regulatory mechanisms involved in ASD and provide potential biomarkers for diagnostic screening.
Julie Vallati at jvallati@pennstatehealth.psu.edu or 7175313049
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Age: 24 Months
•6 Years
Confirmed Diagnosis of Autism or Developmental Delay or Healthy Child
Exclusion Criteria:
Wards of the state
Underlying Seizure Disorder
Underlying Genetic Disorder
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NCT02712853
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A Pilot Trial of Subtyping Pediatric Conduct Problems by the Presence of Severe Persistent Irritability and Callous Unemotional Traits

Youth with irritable and aggressive behaviors, or conduct problems, are thought to be sensitive to rewards and insensitive to punishments. Parents and children will complete rating scales and computer tasks that will assess for sensitivity to rewards and punishments. This study will help to target interventions for treating children with conduct problems.
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Ages 7--12 years
Elevated degree of conduct problems
IQ greater than 80
Exclusion Criteria:
Diagnosis of an intellectual disability, psychosis, ASD, or a pervasive developmental disorder
Sever suicidality
Visual or hearing impairments
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N/A
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Location
Hershey, PA

Memory and Aging Study

This research is being done to find out more about changes in the brain as we age and to determine if MRI, genetic (DNA) variations, and neuropsychological tests can be used to evaluate memory loss and cognitive impairment.
Lauren Spreen at lspreen@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of Alzheimer's disease
Diagnosis of Mild Cognitive Impariment
Normal Controls-Cognitively normal functioning
Exclusion Criteria:
Neurological disease (e.g., stroke, tumor, Parkinson's disease, etc.)
Psychiatric disorder (e.g., bi-polar, schizophrenia, etc.)
History of chemotherapy
Presence of a cold or viral infection
Presence of a pacemaker, aneurysm clips, or any metal in body
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N/A
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Study Locations

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Location
Hershey, PA

Development of a caregiver-report instrument to assess child behavior.

It is commonly agreed that school-aged children display observable attachment behavior, although it is difficult to elicit in laboratory tasks. However, caregivers will observe this behavior on a regular basis when it occurs and can provide useful information regarding the structure and function of that behavior. The goal of the current proposal is to define a potential caregiver-reported instrument assessing early school-age children’s attachment behavior and collect initial data sufficient to examine the factor structure and reliability of the measure. Data collection will utilize anonymous online survey methodology and recruit through schools and preschools.
Brian Allen at ballen1@pennstatehealth.psu.edu or 7175314100
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
Adult caregiver of a child between the ages of 4 and 8
Adult caregiver is at least 18 years of age
Adult caregiver is the primary caregiver of the child.
Exclusion Criteria:
Child has an autism spectrum disorder, intellectual disability, or other developmental delay.
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N/A
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Tongue movement in adults with motor speech disorder

Tongue movement in adults with motor speech disorder
Elizabeth Rodriguez at ezr16@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
be a native speaker of American English
have normal hearing
between 18 and 40 years of age
have no known speech, language, learning or neurological disorders
have very little experience in communicating with people that have motor speech disorders
Exclusion Criteria:
younger than 18 years of age; older than 40 years of age
Not a speaker of American English only
With hearing impairment
have neurologic and/or speech/language disorders
have extensive experience in communicating with people that have motor speech disorders
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N/A
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Study Locations

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Location
State College, PA

Role of angiotensin II and inflammation in persistent vessel dysfunction following preeclampsia

The purpose of this study is to determine what contributes to blood vessel damage during and immediately following a preeclamptic pregnancy. To do this, we examine blood vessel function in the small vessels in the skin. Understanding what contributes to these impairments may lead to better treatments and/or prevention strategies for vessel dysfunction in women who have or had preeclampsia. Two groups of subjects will be enrolled in this study: women who have delivered within 1 year and who have had a preeclamptic pregnancy diagnosed by their obstetrician, and women who have delivered within 1 year and did not have preeclampsia.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
had a baby in the last 12 months
had preeclampsia or did not have preeclampsia
Exclusion Criteria:
had gestational diabetes
history of hypertension prior to pregnancy
current tobacco use
currently pregnant
currently taking medication to lower cholesterol
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NCT03482440
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Location
State College, PA

Exploring Parental Influence in Youth Disability Sport Participation

We are conducting an online survey study for parents of children with disabilities that explores their perceptions of participation in disability sport within their communities.
Courtney Jasiulevicius at cmj5308@psu.edu or 8138464145
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
has a child with a physical disability or sensory disability
has a child that is enrolled in a disability or adapted sport program
has a child between the ages of 10 and 17
Exclusion Criteria:
does not have a child with a physical or sensory disability
does not have a child with a disability between the ages of 10 and 17
does not have a child that plays a disability or adapted sport
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N/A
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Cheese Consumption and Human Microvascular Function

The human body controls the amount of blood flowing through healthy blood vessels. The body performs this vital function by changing the diameter of the blood vessels. The way the body controls blood flow can be different with age and the presence of some diseases such as hypertension (high blood pressure). One of the first signs of a disease that affects blood vessels is a change in the function of the very small blood vessels (microcirculation) of the skin. Studying blood flow control in the skin’s blood vessels helps researchers to learn about the onset and effects of, and develop treatments for diseases that affect blood vessels. Dietary sodium can impair the function of the microcirculation in the skin. This study’s goal is to determine if and how natural cheese may protect against impairments in the function of the microcirculation caused by sodium in an otherwise healthy older people. We conduct a study in which participants eat cheese (6 servings/day) or no cheese during a 7-day low-sodium or high-sodium base-diet. Our approach uses methods specific to the microcirculation to examine how sodium causes human microcirculation impairment and the potential protective effects of natural cheese. Also, we measure blood biomarkers and the function of larger blood vessels to examine the effects of cheese on overall vascular health.
Susan Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Men and women (55-75 years)
Apparently healthy
Normal blood pressure
Non-diabetic (HbA1C <5.7%)
Exclusion Criteria:
Taking a drug that alters peripheral vascular control
Pregnant or Breastfeeding
Females taking contraceptives (pills, patches, shots, etc.) or hormone replacement therapy
Use of nicotine use (e.g. smoking, chewing tobacco, etc.)
Known allergy to latex or investigative substances
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NCT03376555
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Location
State College, PA

Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury

This research is being done to examine the relationship between body composition, metabolism, and dietary needs in people with Spinal Cord Injury.
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
C4-L2 Spinal Cord Injury greater than 12 months
Motor Complete (AIS A & B) spinal cord injury
<5% change in body weight over the past 12 months
Exclusion Criteria:
<22% body fat
Coronary artery disease
Type 1 Diabetes or insulin requiring Type 2 Diabetes
Hypothyroidism
Renal Disease
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N/A
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Study Locations

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Location
Hershey, PA

Mechanisms of neurovascular dysfunction in psoriasis patients

The purpose of this study is to determine what leads to blood vessel and nervous system dysfunction and the increased risk of cardiovascular disease in adults with psoriasis. Psoriasis is an independent risk factor for cardiovascular disease, because cardiovascular disease and psoriasis share common underlying inflammatory causes. This study may lead to treatment and/or prevention strategies to reduce cardiovascular disease risk in psoriasis patients. We explore 1) changes in nitric oxide that could make the body less able to relax blood vessels and 2) changes in sympathetic nervous system function that may contribute to increased cardiovascular disease risk in psoriasis patients. We will investigate the effect of oral salsalate administration on neural and blood vessel function in adults with psoriasis. The study includes experiments that examine blood vessel function in small vessels in the skin and nerve activity in the leg.
Billie Alba at bka125@psu.edu or 814-863-8557
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Men and women (18-65 years)
Apparently healthy
Exclusion Criteria:
Pregnant or Breastfeeding
Allergies to NSAIDs or aspirin
Bleeding disorders or history of gastrointestinal bleeding
Renal disease
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N/A
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Study Locations

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Location
State College, PA

Penn State Hershey Sitting and Health Study

This study aims to examine the effect of pedaling a compact elliptical device at the desk on employees' work productivity. This study also aims to evaluate the effect of different types of incentives on promoting desk-based pedaling.
Liza Rovniak at activitystudy@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Penn State Hershey full time employee
Overweight or obese
Spend at least 5 hours per day sitting at a desk
Have eligible overweight/obese coworker who can do study together with you
18-70 years old
Exclusion Criteria:
Currently pregnant
Planned surgical or medical treatment that will prevent ability to complete study
Heart condition, or chest pain during physical activity
Planned travel or relocation during study period
Already have desk cycling device or treadmill at desk
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NCT03274635
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Location
Hershey, PA

Nasality characteristics in adults with motor speech disorder

The goal of this proposed study is to understand nasality characteristics in individuals with dysarthria (motor speech disorder) secondary to ALS. The research question the proposed study seeks to answer is how does the perception of speakers’ hypernasality relate to the severity of their dysarthria and their nasalance scores.
Elizabeth Rodriguez at ezr16@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
are 18-40 years of age
are a speaker of American English only
have normal hearing
have no neurologic and/or speech/language disorders
have very little experience in communicating with people that have motor speech disorders
Exclusion Criteria:
younger than 18 years of age; older than 40 years of age
Not a speaker of American English only
With hearing impairment
have neurologic and/or speech/language disorders
have extensive experience in communicating with people that have motor speech disorders
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N/A
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Study Locations

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Location
State College, PA

Replication of The Multi-Media Social Skills Project for Adolescents with Autism Spectrum Disorders

Replication of The Multi-Media Social Skills Project for Adolescents with Autism Spectrum Disorders
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between 13 and 17 years of age or still enrolled in high school
A primary diagnosis of Asperger's Syndrome or high-functioning autism, as confirmed by the Checklist for Autism Spectrum Disorders (CASD; Mayes, 2012)
English as primary language spoken
Ability to fluently speak in full sentences
A verbal IQ of 85 or above on the Kaufman Brief Intelligence Test, Second Edition (KBIT-2; Kaufman & Kaufman, 1990)
Exclusion Criteria:
A significant language delay
Difficulty with aggression directed at peers
A primary thought disorder
A secondary disorder of anxiety or depression so severe as to prevent the individual's participation in the treatment
Low social motivation demonstrated through formalized assessment (SRS) and/or by responses given to screening interviews assessing treatment goals
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N/A
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Study Locations

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Location
Altoona, PA
Greater Philadelphia Area, PA
Greater Pittsburgh Area, PA
Hershey, PA
Wilkes-Barre/Scranton Area, PA

Aging and Language

The purpose of this study is to investigate how language is organized in neurologically normal adults using magnetic resonance imaging (MRI) and behavioral measures. Our overarching goal is to characterize the behavioral and MRI responses associated with language production and language comprehension in older and younger adults, and to examine the relations between age, behavior, cognition, and neural factors.
Anna Eppes at aze23@psu.edu or 814-865-2912
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age over 18 years old
Native Monolingual English Speaker
Right-handed
Exclusion Criteria:
History of neurological injury or disease
Taking medications that affect the brain of blood flow
Contraindications to MRI (e.g., pacemaker)
Claustrophobia
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N/A
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Study Locations

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Location
State College, PA

Cyclic Variation in Micronutrient Concentrations and Plasma Volume in Reproductive-Age Women

In this study, we will examine how the menstrual cycle influences micronutrient concentrations in women of reproductive age. We will also examine how the menstrual cycle affects plasma volume in these women. Finally, we will assess the relationship between plasma volume and micronutrient concentrations among study participants. This study involves three visits to the Clinical Research Center (CRC) located in Noll lab, University Park. To participate, interested women will contact the study coordinator via phone or email and provide their name and phone number. A member from the PI lab will contact the interested participant to screen her for eligibility. If a participant is eligible, she will be scheduled to visit the CRC, where eligibility will be confirmed. To confirm eligibility, we will measure her weight, height, blood pressure and conduct a pregnancy test. If eligible, we will conduct hydration test, and measure body composition, then she will complete a short questionnaire about her pregnancy histories and health. She will then rest on bed for 15 to 20 minutes and the nurse will insert an IV to draw some blood ~15mL. Then the nurse will inject her with a small amount of a green dye followed by a series of blood draws (total ~15mL) within the next 5 minutes. She will relax on the bed or sit on a chair for 15 minutes to be monitored by the nurse, to be sure that she is okay. Then we will provide her with a home-based fertility monitor to be used to track her menstrual cycle. We will instruct her on how to use her urine sample to track daily changes in some targeted reproductive hormones during the cycle. The results are displayed in a simple to read format from the monitor. We will use the readings from this monitor to schedule visit 2 (~ day 12 of her cycle). After visit 2, the participant will conduct a few more urine test at home and the results of those tests will be used to schedule her final last visit (~ day 21 of her cycle). On the 2nd and 3rd visits, we will again measure her weight, height, blood pressure and conduct pregnancy to confirm that the participant is still eligible. If we confirm she is still eligible, we will complete the rest of the measurements as in visit one. Blood samples at each visit will be processed and stored at -80C until the data collection is completed. Plasma samples will be processed same day to determine the subject’s plasma volume.
Sixtus Aguree at sua204@psu.edu or 814-867-5938
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Female
18 to 44 years of age
General good health (does not have a known, ongoing health condition/medical issue that requires regular monitoring by a doctor or regular visits to the hospital)
BMI 18.5-24.9 kg/m2
Regular menstrual cycle (26-35 days) & currently non-pregnant
Exclusion Criteria:
Known allergy to shellfish or iodine
Currently using hormonal birth control or used within last 3 months
Blood pressure on the day of measurements is low or high (SBP <100 or >140 mmHg and/or DBP <60 or >90 mmHg)
Current hypertension or previous hypertensive disorder in pregnancy (gestational hypertension or preeclampsia)
Currently trying to conceive
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NCT03422809
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Location
State College, PA

Interoception, the 8th Sensory System, Is it measurable?

Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.
Cheryl Tierney at ctierney@pennstatehealth.psu.edu or 717-531-8414
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
Ages 11-18
Reading at 5th grade level in English
Healthy controls OR high functioning Autism
Exclusion Criteria:
Unable to read at 5th grade reading level
Under age 11 or over age 18
Cannot read English
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N/A
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Prediction of Muscle Force Generation using Ultrasound Imaging and Computational Simulations

The objective of this study is to develop and validate a method to predict force production of individual muscles from ultrasound measurements of muscle stiffness, size, and structure. We hypothesize that there is a linear relationship between muscle size, shear modulus and force generated by the muscle.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy individuals without history of muscle disease or injury
Exclusion Criteria:
Pregnant women
Allergy to ultrasound gels
contraindications to MRI scans
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N/A
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Study Locations

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Location
State College, PA

Lunch Feeding Study for Men and Women

Investigating the relationship between portion size and satiety.
Alyssa Spaw at ads27@psu.edu or 814-863-8482
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
18
•60 years old
BMI between 18 -35
Exclusion Criteria:
<18 years old, > 60 years old
BMI <18 and/or >35
Show full eligibility criteria
NCT03409601
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Location
State College, PA

Factors Impacting Student Perceptions of CIS and CIS Majors

The purpose of this study is to assess the perceptions of students in regards to computing majors and computing’s role in society.
Jeffrey Stone at jas86@psu.edu or 610-285-5003
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Undergraduate Students at Penn State
At Least 18 Years of Age
Exclusion Criteria:
NOT Undergraduate Students at Penn State
Under 18 Years of Age
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N/A
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The effect of fatigue on the exercise pressor reflex

This research is being done to find out if fatigue effects the body's response to exercise.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
At least 21 years old
Healthy
Exclusion Criteria:
Pregnant or nursing women
smokers
taking medication for cancer, heart or lung disease
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N/A
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Study Locations

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Location
Hershey, PA

Prevalence of Shoulder Labrum Abnormalities on MRI in a Non-Athletic Asymptomatic Young Adult Population

The purpose of this study is to determine the prevalence of shoulder and specifically labral abnormalities found on 4.5 Tesla Magnetic Resonance Imaging (MRI) sequences in a young non-athletic cohort. We hypothesize that this population will have greater abnormal findings in their dominant shoulder compared to their non-dominant shoulder.
Jessica Wright at jwright3@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
age 18-28
willing to undergo shoulder MRI
No current injury that interferes with daily living
No history of formal competitive athletics
Exclusion Criteria:
Previous shoulder surgery
Contraindication of MRI
Current shoulder injury that interferes with daily living
Younger than 18 or older than 28
Non-English Speaking
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N/A
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Study Locations

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Location
Hershey, PA

Study driving behaviors in connected and autonomous vehicles with a driving simulator

This is a behavioral study that will examine the effect of different messages designs and driver characteristics on driver behavior using a driving simulator. The driving simulator will be used to simulate various traffic events and record driver behavior and performance in the simulated connected vehicles and autonomous vehicle environments. All you need to do is driving on a driving simulator and complete questionnaires.
Yiqi Zhang at yuz450@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
You must possess a valid and unrestricted driver’s license, and display it to the experimenter
You must not be under the influence of alcohol, and have abstained from drinking alcohol for no less than 8 hours prior to participating in this study
Exclusion Criteria:
Participants who doesn't possess a valid driver license will be excluded from the study
Participants who drinks alcohol within the 8 hours before the study will be excluded from the study
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N/A
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Study Locations

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Location
State College, PA

Reproducibility of neurocardiovascular responses to static handgrip in young adults

Given that habitual physical activity has clear beneficial effects on cardiovascular function, understanding the cardiovascular responses to exercise is important. Importantly, good reproducibility of these responses within an individual is critical for the appropriate interpretation of data. In this study, we are measuring the blood pressure, heart rate, and nervous system responses to exercise and determining their repeatability. This study is being conducted in young healthy adults (18-30 years).
Gabie Dillon at gad27@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
18-30 years
healthy weight
blood pressure <140/90 mmHg
no medications
Exclusion Criteria:
overweight
high blood pressure
medication use
chronic disease
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N/A
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Location
State College, PA

Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis

Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women. Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
• Women, Ages 18-45
• Do or do not have endometriosis
• Have normal blood pressure
Exclusion Criteria:
• Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
• High Blood Pressure
• Abnormal liver function
• Known allergy statins (Lipitor)
• Pregnant or Breastfeeding
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Location
State College, PA

A multi-site randomized clinical trial to compare healthy eating recommendations for six months on changes in visceral adiposity in overweight/obese Americans

The purpose of the Habitual Diet and Avocado Trial (HAT) is to determine whether eating avocados has an impact on decreasing body fat in adults. Consumption of avocado has been linked to a variety of health benefits, but much of this research has been for short periods of time and in small samples.
Kristin Davis at kmd74@psu.edu or 814-863-0856
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
25 years of age or older
Increased waist circumference defined as ≥35 inches for women, ≥40 inches for men
Not currently eating more than 2 avocados per month
Exclusion Criteria:
Does not eat avocados
Not willing or unable to undergo MRI scans
Pregnant, lactating, intention of pregnancy
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N/A
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Study Locations

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Location
State College, PA