This research is being done to find out what triggers an immune response in white blood cells. For example, understanding the triggers of the individual interferon responses may lead to future therapies that are more selective for treating an exaggerated immune response.

A single visit for a whole blood sample.

$30.00

Our research study is testing a brief exercise program designed to help older adults walk better. The exercise program is done from the comfort of the participants' home for only 5 minutes a day!

Meet with an exercise coach virtually via Microsoft Teams Come to Penn State Hershey Medical Center 3 times for appointments Wear a physical activity monitor 3 times Complete surveys

115

A study that looks at the efficacy of Frexalimab compared to placebo in adults with nonrelapsing secondary progressive MS.

This study explores the efficacy and safety of Frexalimab compared to placebo in delaying disease disability progression in non-relapsing secondary progressive multiple sclerosis (nrSPMS). There will be about 53 in person visits over 4.5 years that consist of monthly IV medication administration, vitals, monthly blood draw for lab work, clinical outcome assessments, ECG, and Magnetic resonance imaging (MRI) roughly every 6 months. All study activities will be done at the Penn State Health Hershey Medical Center in the Neurology Clinic at 30 Hope Drive and Clinical Research Center (CRC) in the main hospital.

Up to $4300

This study is being done to answer the following question: Can we shrink the amount of AML or get rid of it in your bone marrow and body by treating you with the standard approach of cytarabine + daunorubicin (7+3) or one of the following experimental groups: 1) cytarabine and daunorubicin with venetoclax 2) azacitidine and venetoclax, 3) daunorubicin and cytarabine liposome, or 4) daunorubicin and cytarabine liposome with venetoclax? Study will last 5 years. After study treatment, doctor will continue to follow condition for 5 years and watch for side effects. The follow-up care may be in-person clinic visits or phone calls. They will check subject every month for 1 year after they join the study. After that, they will check subject every 2 months for the second year, every 3 months for the third year, and every 6 months for the fourth and fifth years.

Study will last 5 years. After study treatment, doctor will continue to follow condition for 5 years and watch for side effects. The follow-up care may be in-person clinic visits or phone calls. They will check subject every month for 1 year after they join the study. After that, they will check subject every 2 months for the second year, every 3 months for the third year, and every 6 months for the fourth and fifth years.

This study is being done to answer the following question: Will preventative radiation therapy lower the number of bone metastases-related complications (such as fracture caused by the tumor in the bone and tumor pushing on the spinal cord) compared to the usual approach? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your type of cancer. The usual approach is defined as care most people get for high-risk bone metastases that are not causing symptoms.

If the participant decides to take part in this study, they will either get the usual approach or they will get radiation therapy for up to 5 days plus the usual approach. After the participant finishes treatment, the doctor and study team will continue to follow their condition and watch for side effects. The doctor and study team will check the participant 3, 6, 12, and 24 months after they join the study.

This a pilot study that will evaluate the feasibility of assessing perceived barriers to accessing clinical trials in the PSCI patient population through a questionnaire.

Patient need to fill out a survey about accessing clinical trials to the best of their ability.

We will ask people who currently use—or have used—hair-styling tools (e.g. Dyson Airwrap, Shark Flexstyle) to complete an online questionnaire about how easy the tools are to use and how loud they seem. Our goal is to understand user experiences and preferences so manufacturers can design quieter, more user-friendly devices.

There will be an online consent form and an eligibility questionnaire before an approximately 10 minute survey on Qualtrics.

Participants will be required to come to all study visits. At those visits the following may occur, blood tests to see if you are well enough to participate or continue to participate in the trial, a physical exam by the study doctor, meeting with the study team to talk about how you are feeling followed by getting toripalimab and chemotherapy. At other time you will need to have scans to see if how your cancer has responded to the treatment. These visit will continue until your cancer grows back, doesn’t respond to the treatment or the study is stopped by the sponsor. Although toripalimab is approved for the treatment of NPC, it is not approved to be used with these other two drugs.

Participants will be required to come to all study visits. At those visits the following may occur, blood tests to see if you are well enough to participate or continue to participate in the trial, a physical exam by the study doctor, meeting with the study team to talk about how you are feeling followed by getting toripalimab and chemotherapy. At other time you will need to have scans to see if how your cancer has responded to the treatment. These visit will continue until your cancer grows back, doesn’t respond to the treatment or the study is stopped by the sponsor.

Testing the effects of low-impact vibration training vs. body squats only on strength, balance, and walking outcomes in people aged 40-65 years.

There will be one study visit lasting approximately 2.5 hours. Following a short screening and consent process, study participants will complete a series of baseline tests to acquire information about body composition, walking ability, strength, and balance. Participants will then complete a workout consisting of vibration training group or a squats only. Each workout will last approximately 10-minutes. The tests will be repeated to assess any changes resulting from the training.

$25.00

this trial will see if using Rina S is better in treating ovarian cancer than standard treatment.,

Participants will need to come in for all study visits, take the medication as instructed, report all side effects and all medications including over the counter ones to the study team.

RO7790121 will be used in the adult patients with Ulcerative colitis, to find out if it is safe and efficient in treatment of ulcerative colitis. The subjects will receive either RO7790121 drug or a placebo. After 12 weeks, the participants who complete treatment can continue to the open label treatment and receive a drug. Induction will consist of about eleven visits to the study site. The subjects will receive four intravenous treatments of either a drug or the placebo.

All subject must show understanding of the study requirements and sign the informed consent. The participants will have study procedures done, such as colonoscopy with biopsies, blood draws, and if eligible, they will be randomized at the start of induction treatment. The treatment will consists of the study drug or placebo. They will receive treatment by infusion in five study visits. After twelve weeks, the patience will be evaluated and they could continue to the open label treatment.

$75 per completed visits including endoscopy, and up to $50 for travel compensation for completed visit. You can receive a total of $1380.00 for your participation in the study.

Several easy methods will be used to study how blood vessels change in middle-aged people. These methods include heating a small spot on the arm, using a small TENS unit, using an ultrasound with a blood pressure cuff on the arm, and taking a blood sample.

There will be 2 in-person visits, one will be ~1 hour, the other will be ~2. We will take a blood sample at each visit. The second visit will require you to be seated and resting the entire time.

75

This research study aims to address a gap in the current literature by focusing on technology acceptance and usage factors among minority elderly individuals. The overall goal of this study is to find the perceived barriers and reasons for the digital healthcare divide within the minority elderly population in respects to patient portals.

All participants will be required to review an informed consent form prior to starting the survey or interview. Participants will be screened for eligibility criteria via questions on their age, race, and if they reside in the United States. If they meet the study's inclusion criteria, they will be able to complete the survey and/or interview focusing on electronic patient portals and demographic questions, along with data privacy, security, and data governance questions regarding patient portals.

This is an exploratory sequential mixed methods study that will explore the extent to which the barriers of diagnostic delay in Black women with endometriosis are generalizable to the general endometriosis population. There will be two phases of this study: a qualitative phase followed by a quantitative phase. The qualitative phase will involve semi-structured interviews with Black women who have a confirmed endometriosis diagnosis. The findings from the qualitative phase will be used to modify a questionnaire for the quantitative phase of the study. The quantitative phase will be a short questionnaire, taken by endometriosis patients of any racial/ethnic background with a confirmed diagnosis.

Participants will be asked to complete a 15 minute online questionnaire about their experiences with receiving an endometriosis diagnosis. Questions will include demographic information, endometriosis history, and perceptions of barriers that contributed to a delayed diagnosis.

$10

This study is trying to understand more about factors that cause pain in people who have had experiences of discrimination.

2 in-person visits 3-4 hours each plus at-home online questionnaires In-person visits will involve: 1. Sensory and pain testing 2. Physical function testing 3. Blood draw 4. MRI scan 5. Questionnaires

Up to $250

The purpose of this study is to evaluate the effectiveness and safety of navenibart as a preventative treatment for people with Type I or Type II Hereditary Angioedema (HAE).

You will need to come to Penn State Health Milton S. Hershey Medical Center 8 times. You will answer questions about your health/HAE attacks, provide blood samples, undergo routine urine laboratory tests, receive the trial drug, undergo electrocardiogram (ECG), complete questionnaires, undergo physical exams, and provide HAE attack information.

A sample repository for the examination of biomarkers for Amyotrophic Lateral Sclerosis (ALS) and other Motor Neuron Diseases

Participants will be asked to donate blood one or more times and provide age, sex and general history of neurological disease. ALS/motor neuron disease patients will be asked to release information from the medical record about their neurological disorder, strength, function, treatments, known pathogenic ALS-related gene variants, quality of life, and results of breathing tests.

The purpose of this study is to compare the usual radiation therapy and usual chemotherapy, temozolomide, to using the usual radiation therapy and usual chemotherapy plus the chemotherapy drug lomustine (Gleostine). Lomustine (Gleostine) is already approved by the FDA for use in brain tumors but it is usually used alone and is not the first-line choice for methylated MGMT tumors.

• Group 1 If you are in this group, you will get the usual approach used to treat this type of cancer (radiation plus temozolomide, followed by temozolomide alone). You will receive radiation plus temozolomide for about 6 weeks. During this time, you will receive radiation 5 days per week and temozolomide every day. Beginning about 1 month after you finish radiation, you will receive temozolomide for 5 days in a row every 4 weeks for up to 6 months. You will get temozolomide as a pill you take by mouth. After radiation, you may receive the Optune device if you and your treating physician decide it is best for you. There will be about 153 people in this group. • Group 2 If you are in this group, you will get the usual treatment of radiation 5 days per week for 6 weeks with the chemotherapy drugs lomustine (Gleostine) and temozolomide.. You will get both lomustine (Gleostine) and temozolomide as pills you take by mouth. After radiation, you may receive the Optune device if you and your treating physician decide it is best for you. There will be about 153 people in this group.

This trial will examine the outcome of comparing Sonrotoclax Plus Zanubrutinib vs. Zanubrutinib alone in the treatment of mantle cell lymphoma

Participants must come to all study visits, take the medication as instructed, tell the study how you are feeling and tell the study team about any medications you are taking, especially over the counter medications.

This study is for participants who have a brain tumor and decide with their doctor to use GammaTile radiation therapy to treat their brain tumor. This treatment is FDA approved. The purpose of this study is to collect data on how this treatment impacts your health and wellbeing.

There are no required visits or treatments for this study. At your regularly scheduled doctor visits, your study doctor or staff will enter relevant health and medical information into the study database. You will also be asked to complete questionnaires about the quality of your life during your routine medical appointments.

Each participant will have a maximum study participation of 61 weeks, which includes a total duration of study treatment approximately 52 weeks: Period 1 (double-blind, placebo-controlled treatment; 16 weeks) and Period 2 (double-blind, active treatment; 36 weeks). At different timepoints throughout the study subjects will have their skin examined, have labs drawn, have an ECG perfomed, as well as answer questionnaires.

Study participation will last approximately 56 weeks. During the study, participants will attend 20 in person visits in the research office. At different timepoints the participant will have their skin examined, blood drawn, have an ECG done, answer questionnaires and take study medication as directed by the study team.

Older and younger adults may differ in how they comprehend language. Here we plan to EEG of word and sentence processing to understand differences in how older and younger adults use context to form predictions.

There will be a single, 2-hour visit in which your 'brain waves' are recorded while you read words. We will also ask you to complete pencil and paper tasks and computer tasks to learn more about how your brain works.

$30

The purpose of this study is to measure Event Free Survival (EFS) with IL cemiplimab (investigational intervention) compared with primary surgery for participants who have an eligible CSCC (cutaneous squamous cell carcinoma) that is great than or equal to 1 to less than or equal to 2 cm in the longest diameter. The maximum length that a participant will be on study is approximately 3 years. Participants will be assigned 2 to 1 to either the experimental arm or the control arm.

The maximum length that a participant will be on study is approximately 3 years. Visit Frequency: - Experimental Arm: Every week for 6 treatment visits. There is a clinical visit for TL assessment on Week 8. Assessment of response at the TL site occurs at week 13. -Control Arm: 1 day for surgery, with post-surgical visits at week 3 and week 13 -Both Arms: Week 19, then every 3 months for years 1 and 2, and every 4 months for year 3. Additional visits may occur for clinical issues that may arise, per standard of care. At different timepoints throughout the study participants will have their skin examined and photographed, answers questionnaires/interview, have blood drawn, and have a biopsy.

We know that both what (e.g., apples, pizza) and how (e.g., large vs small bites, fast vs slow) can contribute to overeating. The study will be focused on how children eat. We want to see if children eat the same way in the lab as they eat at home. We will assess laboratory and home eating styles (e.g., bite rate) in 100 prepubertal 6-9-year-old children. Children will be video-recorded while consuming identical study-provided meals at home and in the laboratory in addition to a ‘typical’ meal at home.

Healthy 6-9 year-olds and their parents are needed for the MEAL-TIME Study at Penn State University. We are looking for children to help us learn about how kids respond to different types of foods and computer games. The study consists of 3 visits to our facilities in Noll and Chandlee Labs, located on the University Park Campus. Your child will eat a meal and complete computer game tasks at each visit. Between visits, you will be asked to record your child eating at home using a study-provided smart phone. Your child will also complete an IQ test. Some children may experience anxiety when completing clinical procedures (e.g., height, weight). You and your child will be compensated $50 per visit for a total of $150. Each visit is expected to be 1.5 hours long and at-home meal recordings are expected to take 30-45 min, for a total of 8 hours participating in our lab.

$150

The purpose of this research study is 1.) to determine if Parkinson’s Disease (PD) causes changes in the way that people sense the movements of and forces produced by their bodies, and to connect any of these changes in sensation to changes in the brain, and 2.) to identify how changes in movement might come from different parts of the nervous system. This study will use a combination of electromyography, via electrodes placed on the skin, and finger force recordings to infer how PD affects patients' sense of force production, and the neural mechanisms underlying this change.

Participants will complete a phone screen, then attend one in-person visit at Penn State Health. During the visit, they will perform finger-pressing tasks, have surface electrodes placed on their skin to record muscle activity, complete motor and memory assessments, and fill out questionnaires.

40

This study is loking at how a new drug treats breast cancer. The breast cancer must have the following genetic mutations BRCA1, 2 or PALB2

You will need to come to all the study visits, take the study medication as prescribed, tell the study doctor about all medications you are taking, including over the counter and to tell the doctor how you are feeling.

AHOD2131:A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab. This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma.

Consent to treatment, required labs and imaging, sample collections, and completion of research study tests and surveys and/or questionnaires.

This phase III trial compares standard chemotherapy to therapy with CPX-351 and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. CPX-351 is made up of daunorubicin and cytarabine and is made in a way that makes the drugs stay in the bone marrow longer and could be less likely to cause heart problems than traditional anthracycline drugs, a common class of chemotherapy drug. Some acute myeloid leukemia patients have an abnormality in the structure of a gene called FLT3. Genes are pieces of DNA (molecules that carry instructions for development, functioning, growth and reproduction) inside each cell that tell the cell what to do and when to grow and divide. FLT3 plays an important role in the normal making of blood cells. This gene can have permanent changes that cause it to function abnormally by making cancer cells grow. Gilteritinib may block the abnormal function of the FLT3 gene that makes cancer cells grow. The overall goals of this study are, 1) to compare the effects, good and/or bad, of CPX-351 with daunorubicin and cytarabine on people with newly diagnosed AML to find out which is better, 2) to study the effects, good and/or bad, of adding gilteritinib to AML therapy for patients with high amounts of FLT3/ITD or other FLT3 mutations and 3) to study changes in heart function during and after treatment for AML. Giving CPX-351 and/or gilteritinib with standard chemotherapy may work better in treating patients with acute myeloid leukemia compared to standard chemotherapy alone.

Consent to treatment, required labs, sample collections, and completion of research study tests and surveys and/or questionnaires.

This phase 3 trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs that work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. The overall goal of this study is to see if selumetinib works just as well as the standard treatment of CV for patients with LGG. Another goal of this study is to compare the effects of selumetinib versus CV in subjects with LGG to find out which is better. Additionally, this trial will also examine if treatment with selumetinib improves the quality of life for subjects who take it.

Consent to treatment, required labs, sample collections, and completion of research study tests and surveys and/or questionnaires.

To evaluate safety of combining chemotherapy (cisplatin and gemcitabine) with an anti-PD1 immune checkpoint inhibitor (nivolumab) in children, adolescents and young adults with nasopharyngeal carcinoma (NPC) by determining the rate of CTCAE Grade 3 or higher immune related adverse events (irAEs).

Consent to treatment, required labs, imaging, and sample collections.