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The purpose of this study is to find out if full-fat dairy and low-fat dairy have similar effects on risk factors for heart disease and diabetes. The study will take approximately 4 months to complete. During the study, participants will consume two types of dairy products: low-fat dairy (milk, yogurt, and cheese) and full-fat dairy (milk, yogurt, and cheese). Each type of dairy will be consumed for 6 weeks with a ≥4-week break between. Participants will be provided with all the dairy products. Testing will be conducted on two separate days at the beginning and end of each 6-week study period (a total of 8 testing days).

• The total time commitment for this study is approximately 4 months. It may take up to 7 months to complete the study from the time that you do the clinic screening visit. • During the study, you will be asked to consume two types of dairy products: low-fat dairy (milk, yogurt, and cheese) and full-fat dairy (milk, yogurt, and cheese). We will provide you with the dairy products. • Each type of dairy will be consumed for 6 weeks with a ≥4-week break between. • You will be asked to come to the Penn State Research Kitchen on campus every 7 days during each 6-week period to pick up your dairy products. • We will draw blood from you several times during the study, once at screening, and on two consecutive days at the start and end of each study period (total 9 times). • At the start and end of each period, we will also measure your blood pressure and perform non-invasive tests of artery health. • You will also be asked to collect a stool sample at the beginning and end of each study period (4 total).

$400

The potential participants must have Crohn's disease diagnosis. They should have had previous standard or advanced therapies for CD and have been intolerant or have lost response. They will be asked to sign and understand the informed consent. The volunteers will provide biological specimens blood, urine, stool, and the biopsy during endoscopy. They will answer daily diary questions about the symptoms, and complete questionnaires in the clinic. The screening will involve at least two visit and will last five weeks. They will be treated in the open label sub-study 1, or double-blinded randomization with placebo in the sub-study 2. The non-responders will be eligible for extended induction in sub-study 3. Each sub-study is 12 weeks long.

Participants will attend in person visit at the research clinical facility in Hershey, PA. If they sign the informed consent and want to participate, they will have vitals checked, and physical examination done. They will provide specimens such as blood and stool. They will answer questionnaires at home and in the clinic. The endoscopy will be done with biopsy to evaluate the disease response to the treatment at screening and week 12, or week 24 for the extended induction if applicable. The drug will be administered by subcutaneous injection in the clinic or at home. There will be a compensation for every completed clinic visit.

TBD

Exercise conducted above the shoulders (i.e., overhead exercise) can reduce blood flow and oxygen delivery to the exercising muscle due to the effects of gravity. This ultimately leads to greater muscle fatigue during overhead exercise tasks which can lead to fatigue-related injuries in occupational settings. Cold-water exposure increases blood pressure (i.e., cold pressor response) and could increase blood flow to exercising muscle by increasing muscular perfusion pressure (i.e., pressure that pushes blood into the muscle) during overhead exercise. This has the potential to reduce muscle fatigue during overhead exercise. However, no studies to date have investigated the effect of cold-water exposure on muscle fatigue during overhead exercise.

There will be 4 in person visits at Penn State Altoona for this study. The first visit will be ~1 hour and the other 3 visits will be ~30 minutes. Participants will complete questionnaires, undergo body composition measurements, and resting blood pressure and heart rate measurements during visit 1. Participants will complete a handgrip exercise test during each visit and their arm will be placed in different positions (overhead or straight in front) during the exercise test. Blood pressure, muscle oxygen levels, and blood flow will be measured during the exercise test. During two of the visits, the participant's foot will be exposed to cold water (~40 degrees F) with a cold-water foot sleeve for a brief period of time (1-3 minutes).

$25

This is a behavioral and biological research study that will examine how first-time parents’ interactions, brain activity, and hormone levels during pregnancy are related to later parenting and infant development. Participants will complete questionnaires, take part in video-recorded interaction tasks, wear a non-invasive brain activity monitor, and provide saliva samples. At a follow-up visit, parents and their infant will participate in similar activities together.

There will be two in-person lab visits for first-time expectant father–mother couples: one during pregnancy and one when the baby is about 8 months old. During both visits, participants will complete questionnaires, take part in interaction tasks, wear a soft headband to measure brain activity, and provide saliva samples. At the second visit, parents will complete similar activities together with their baby, including parent–infant interaction tasks.

Up to $375 per family (including travel reimbursement)

This trial will see if bevacizumab, in combination with carboplatin, paclitaxel, and pembrolizumab is better than carboplatin, paclitaxel, and pembrolizumab (the control arm) or carboplatin, paclitaxel, and bevacizumab in prolonging survival.

After it has been determined that it is safe for you to participate, you will be randomized to one of three treatment combinations. All of the arms will use real drug to treat your cancer. You will need to come to the clinic every three or every six weeks for treatment. You will continue treatment until your cancer comes back, you do not want treatment any more or the doctor feels it is not safe for you to continue. You will then be followed for five years once you complete all treatment.

This qualitative research study uses the Interpretative Phenomenological Analysis (IPA) method to explore the lived experiences of first-generation adult students who have graduated from fully online college degree programs. The primary goal is to gain a deeper understanding of how these individuals made meaning of their academic journeys, the challenges they faced as first-generation students, and the factors that contributed to their success in an online learning environment. Participants will engage in one-hour open-ended interviews with the researchers held via Zoom videoconference

All participants will complete a brief 5-minute screening process via Zoom to determine eligibility. If participants meet the study criteria and are interested in moving forward with the study, an approximately 60-minute Zoom interview will be conducted. The interview will discus their experiences as first-generation adult graduates of fully online bachelor’s degree programs. A brief follow-up interview may be requested if clarification is needed.

$50 Amazon Gift Card

The purpose of this study is to evaluate the effectiveness of the Growing Healthy Hearts (GHH) program, a remotely delivered gardening, nutrition, and cooking intervention, on cardiovascular health behaviors and outcomes among adults with cardiovascular disease (CVD) risk factors who have a child living in the home. Participants will be randomized to either the GHH intervention or a waitlist control group. The intervention is designed to promote sustained improvements in fruit and vegetable intake and physical activity by leveraging interest in gardening as an entry point for behavior change and by providing integrated education in gardening, nutrition based on the Dietary Approaches to Stop Hypertension (DASH) eating pattern, and cooking skills.

2 arm randomized controlled trial (intervention and waitlist control) Intervention group will be required to meet virtually 5 times for the study visits and attend two zoom sessions a month for 6 months.

$410

SPK-8011QQ is a one time IV infusion gene therapy drug. The purpose is providing an adeno-associated viral vector (a non-disease vector transport) to carry a human FVIII gene to the liver in order to increase the production of FVIII. This study will assess the safety & tolerability of SPK-8011QQ. Patients will receive a single dose of SPK-8011QQ & will then be followed for approx. 5 years. Total visits (all on-site) will be approx. 52.

SPK-8011QQ is a one-time IV infusion gene therapy drug. The purpose is providing an adeno-associated viral vector (a non-disease vector transport) to carry a human FVIII gene to the liver in order to increase the production of FVIII. This study will assess the safety & tolerability of SPK-8011QQ. Patients will receive a single dose of SPK-8011QQ & will then be followed for approx.5 years. Total visits (all on-site) will be approx. 52.

$75.00 travel reimbursement, $180.00 for the screening visit & day of infusion visit. A $130.00 stipend for each in person visit is also included.

The LAAOS-4 study is to determine if closure of the left atrial appendage using a closure device called the WATCHMAN, in addition to taking oral anticoagulant medications, is more effective at reducing strokes and blood clots in the body, than taking oral anticoagulant medications on their own.

The research study involves eleven visits, one being in person and ten being completed by telephone. A review of your medical history, current medications, and questionnaires at each visit. If you are randomly chosen to have the WATCHMAN closure device, this will involve an overnight stay in the hospital after the device implant.