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Strengths, Outcomes, Adversity, and Resilience in College-Aged Childhood Cancer Survivors: The PSU SOAR Study

The purpose of this study is to analyze the strengths, outcomes, adversity, and resilience, as indicated by self-reported experiences in college students who may or may not be childhood cancer survivors. We are asking college students aged 18-23 years attending 4 year universities in the United States to report on their childhood health experiences and their current mental, physical, and social well being during college using a confidential survey. We plan to recruit students who have or have not had a childhood history of cancer and will also ask questions about their demographic information and health habits.

The participants will be asked to complete a confidential online survey that will take 10-15 minutes to complete.

Participants are eligible to earn a $75 Amazon gift card through a random drawing that they can choose to enter after submitting their survey responses

No
 

Laura Klein
Nikolette Nolte - at nmn5225@psu.edu or 484-268-6550
Biobehavioral Health (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00019071
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Inclusion Criteria:
Aged 18-23 years
College student attending 4 year university
English as primary language

Exclusion Criteria:
Younger than 18 years or older than 23 years
Not attending a 4 year university
Does not have English as primary language
Mental & Behavioral Health, Cancer
Not applicable
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PSCI #24-126 A Phase III Trial Of Perioperative Versus Adjuvant Chemotherapy For Resectable Pancreatic Cancer.

This study is for subjects who have removable pancreatic cancer. If subjects decide to take part in this study, subjects will either get the study drugs FOLFIRINOX for about 4 months followed by surgery and then more FOLFIRINOX for about 2 months, or subjects will get surgery followed by FOLFIRINOX for about 6 months. After subjects finish their treatment, the subject's doctor will continue to watch them for side effects. They will check subjects in the clinic every 4 months for 2 years after you started the study. After that, they will check subjects either in the clinic or by phone every 6 months for 6 years after the subject started the study. This means that the subject will keep seeing or hearing from their doctor for 6 years after they started the study.

Subject will either get the study drugs FOLFIRINOX for about 4 months followed by surgery and then more FOLFIRINOX for about 2 months, or the subjects will get surgery followed by FOLFIRINOX for about 6 months. After treatment the doctor will continue to watch for side effects. They will check on the subjects in the clinic every 4 months for 2 years after the subject started the study. After that, they will check the subject either in the clinic or by phone every 6 months for 6 years after you started the study. This means that the subject will keep seeing or hearing from your doctor for 6 years after you started the study.

Yes
 

Nelson Yee
Kelly Sentz-Brenneman - at ksentzbrenneman@pennstatehealth.psu.edu or 717-531-7417
Medicine: Hematology and Medical Oncology (HERSHEY)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT04340141
STUDY00025939
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Inclusion Criteria:
Pathology: Histologic or cytologic proof of pancreatic adenocarcinoma or adenosquamous carcinoma. TNM Stage: Tx-4, N0-1, M0*
No evidence of metastatic disease
Less than 180° interface between tumor and vessel wall of the portal vein or superior mesenteric vein, and patent portal vein/splenic vein confluence
No involvement or abutment of the celiac artery, common hepatic artery, superior mesenteric artery, or replaced right hepatic artery (if applicable)
Age ≥ 18 years

Exclusion Criteria:
Gilbert’s Syndrome or known homozygosity for UGAT1A1*28 polymorphism
comorbid conditions that would prohibit curative-intent pancreatectomy
ECOG Performance Status greater than 0-1
Cancer
Approved drug(s)
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Hershey, PA ,

The role of thromboxane A2 and its receptor in vascular regulation in women with endometriosis

Women with endometriosis have more thromboxane being produced in their platelets. Thromboxane affects blood vessels, making them constrict, and sensory nerves, making them more sensitive. This study will determine if women with endometriosis are negatively effected by the excess thromboxane.

There will be three in-person visits: one screening and two experimental visits. Participants will take aspirin before one visit and a placebo before the other then will undergo brief tests of nerve sensitivity and a blood draw.

$150

Yes
 

Lacy Alexander
Sue Slimak - at sks31@psu.edu or 814-863-8556
Kinesiology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT05962034
STUDY00021851
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Inclusion Criteria:
18-48 years
born with a uterus
with and without endometriosis

Exclusion Criteria:
diagnosed cardiovascular disease
hormone replacement therapy within previous 2 months
nicotine use
pregnant or breastfeeding
aspirin allergy or hypersensitivity
Heart & Vascular, Pain Management, Women's Health
Approved drug(s)
I'm interested
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Study Locations

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Hershey, PA ,
State College, PA ,

Interlimb differences in Motor Control and Learning

This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.

Yes
 

Robert Sainburg
Brooke Fosaaen - at sainburglab@psu.edu or 814-865-7937
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
PRAMS00040722
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Inclusion Criteria:
over the age of 18

Exclusion Criteria:
neurological disease
upper-extremity orthopedic injuries that interfere with participation
Neurology, Sports Medicine, Muscle & Bone
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Hershey, PA ,
State College, PA ,

PSCI 23-144 NRG-LU008: PHASE III PROSPECTIVE RANDOMIZED TRIAL OF PRIMARY LUNG TUMOR STEREOTACTIC BODY RADIATION THERAPYFOLLOWED BY CONCURRENT MEDIASTINAL CHEMORADIATION FOR LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER

Patients diagnosed withy inoperable node positive non small cell lung cancer will be randomized to with radiation therapy to all know sites of disease in the lung, followed by immunotherapy or radiation to the primary lung tumor, followed by radiation to the lymph nodes followed by immunotherapy

Participants will be required to come to all study visits, report to the study doctor any new medications, prescription or over the counter that they may be taking,

Yes
 

Joseph Miccio
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
Radiation Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05624996
STUDY00024448
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Inclusion Criteria:
Pathologically (histologically or cytologically) proven diagnosis of Stage II or III (AJCC Eighth Edition) non-small cell lung cancer (NSCLC) with known PD-L1 status prior to registration.
The patient must be deemed clinically appropriate for curative intent definitive combined modality therapy, based on the following staging assessments:
No evidence of distant metastases based on FDG PET/CT scan obtainedwithin 60 days of registration.
Primary tumor ≤ 7 cm;
Age ≥ 18;

Exclusion Criteria:
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields that is determined by the treating physician to impede the treatment of the study malignancy.
Patients without identifiable primary tumor
Centrally located primary tumor < 2 cm from involved nodal disease which would result in significant overlap of the primary SBRT and nodal radiation fields
Participants who are pregnant or unwilling to discontinue nursing.
Participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) unwilling to use highly effective contraceptives during therapy
Cancer
Approved drug(s)
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Hershey, PA ,

Human Interaction with Information and Communication Technology

This study investigates users’ experience with Information and Communication Technology (ICTs). This study makes further implications for designing more user-friendly ICT for a better user experience. We aim to make such contributions by answering these questions:1.How do users interact with ICTs?2.What challenges do users face when using ICTs?3.What strategies do users apply to adapt themselves to ICTs?4.What service do ICT producers provide for users to get better user experience?5.When does user experience break down when interacting with ICTs?

No
 

Yao Lyu
Yao Lyu - at yml5549@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016978
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Inclusion Criteria:
18 years or elder
all genders included
have prior experience with ICT
speak Madarin or English

Exclusion Criteria:
younger than 18 years old
vulnerable populations like cognitive impaired adults, prisoners.
no prior experience with ICT
speak neither Madarin nor English
I'm interested
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Normalizing preteen HPV vaccination with practice-based communication strategies (Protect Them)

This study seeks to adapt and test a culturally-relevant, web-based game intervention to motivate Spanish-speaking preteens to initiate and complete human papillomavirus (HPV) vaccination. The present study will adapt an existing web-based game developed as an educational tool on HPV vaccination for English-speaking preteens in North Carolina. The study includes the recruitment of paired dyads (Spanish-speaking preteens and parents) to focus groups to evaluate the acceptability of cultural adaptations to the existing web-based game intervention. We will recruit up to 25 parents and preteens ages 11-12 who will receive a link to the Spanish game to play for 7-10 days in advance of the focus group discussions. The focus groups will ask participants about cultural and language adaptations to the existing game and how they react to a game that will serve as an interactive, educational tool on HPV vaccination. The focus groups will take place in Harrisburg, PA between January and March of 2018. No health information will be collected as part of this study.

Yes
 

William Calo
William Calo - at wcalo@phs.psu.edu or 717-531-3535
Public Health Sciences (HERSHEY)
 

All
All
This study is also accepting healthy volunteers
SITE00000339
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Inclusion Criteria:
Pretens 11 or 12 years old
Not vaccinated with the HPV vaccine
Have computer, tablet, or smartphone

Exclusion Criteria:
Having received the HPV vaccine
Children's Health, Prevention
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Harrisburg, PA ,

How Immigration Looks to America: Perspectives of the Photographic Portrayals of Immigrants in News Photographs

This study will involve surveying college students regarding their perceptions about how immigrants are portrayed in news media.

No
 

Hans Schmidt
Hans Schmidt - at hcs10@psu.edu or 610-892-1251, ext=6108921251
Academic Affairs (BRANDYWINE)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00014540
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Inclusion Criteria:
Student at Penn State

Exclusion Criteria:
Below age 18
Education
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Dynamic Assessment of Vocabulary Learning Strategies

To provide better understanding of Chinese students' vocabulary learning Strategies and help develop better learning strategies

Complete seven sessions, which may take approximately 20-30 minutes of your time per session.Read several English short texts and identify meanings of target words.Possibly participate in a virtual interview that will be scheduled at your convenience.

No
 

Yuwei Xia
Yuwei Xia - at yxx5304@psu.edu or 626-999-1712
Division of Graduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00021134
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Inclusion Criteria:
Of Chinese origin or descent
Adult English learners
Currently enrolled in a college or university

Exclusion Criteria:
English as Native Language
Not Chinese
Education
Not applicable
I'm interested
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Watch Over: Using Apple Watches to Assess and Predict Substance Co-use in Young Adults

This study seeks to understand substance use and other health behaviors in young adults' daily lives. Interested participants can email the study team to complete a brief screener to see determine their eligibility. If eligible, participants will be asked to complete a short online survey and follow-up surveys for up to four weeks via a mobile device. Financial compensation will be provided.

This study involves three parts. First, potential participants will complete an online screener survey. If they are eligible, they will be immediately enrolled in the study and will proceed to the baseline survey. Second, participants who have completed the baseline portion of the study will schedule an in-person visit with the research team for the next portion of the study. At the start of the in-person visit, participants will be oriented about the study design which involves completing daily surveys about various health behaviors. Third, participants will come back in-person for a brief final visit and receive payment.

76

Yes
 

Saeed Abdullah
Sahiti Kunchay - at sahiti@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00013672
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Inclusion Criteria:
Between 18-25 years of age
Current Penn State student
Currently owns and uses an iPhone with iOS version 15 or newer
Determined eligible through screener

Exclusion Criteria:
Eligibility determined using a screening survey
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State College, PA ,

CCTG MA.39- A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer

Purpose of this study is to compare any good and bad effects of not using regional radiotherapy to using radiotherapy. The study will help researcher learn if not giving regional radiotherapy is just as good as using regional therapy to treat node positive breast cancer in women.

Blood will be drawn at two time points and number of visits will be determined by the individual radiation treatment plan.

Yes
 

Marc Rovito
Michelle Eschbach - at meschbach@pennstatehealth.psu.edu or 610-378-2336
Cancer Institute (ST. JOSEPH)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03488693
AFFILCCTGMA39
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Inclusion Criteria:
Estrogen Receptor Positive / Her2 Negative Breast Cancer
No evidence of metastasis
1 - 3 positive lymph nodes
May have had breast conserving surgery or mastectomy
35 years of age or older

Exclusion Criteria:
Nodal disease limited to micromets or isolated cells
History of ipsilateral breast cancer or DCIS
Synchronous or contralateral breast cancer
pT4 disease
Neoadjuvant Chemotherapy for breast cancer
Cancer
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Reading, PA ,

Dining Out in NYC: Using VR to investigate the influence of multisensory urban design factors on eating behavior in emerging adults

This study uses virtual reality to investigate how sensory aspects of an environment influence eating behavior. Specifically, subjects will be immersed in a virtual outdoor café environment and consume a standardized meal while being exposed to either a pleasant or unpleasant smell. Total food intake and mood will be measured following each visit.

Answer initial screening and demographics questionnaires. Two in-person visits to the lab to experience a VR setting and consume a provided meal. One visit will include a small hair sample. Answer questionnaires following the VR experience.

$20 in Amazon gift cards

Yes
 

Travis Masterson
Christina Blackmon - at cmb8633@psu.edu
Nutritional Sciences (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT06662149
STUDY00025849
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Inclusion Criteria:
Ages 18-29
Fluent in English
Not color blind or nose blind
No food allergies/sensitivities
No diagnosis of mental or physical disabilities that may affect appetite, eating behavior, or body awareness and balance (such as eating disorders, Major Depressive Disorder, epilepsy, and vertigo)

Exclusion Criteria:
Younger than 18 or older than 29
Not fluent in English
Color blind or nose blind
Self-reported food allergies/sensitivities
Have diagnosis of mental or physical disabilities that may affect appetite, eating behavior, or body awareness and balance (such as eating disorders, Major Depressive Disorder, epilepsy, and vertigo)
Food & Nutrition, Mental & Behavioral Health
Not applicable
I'm interested
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State College, PA ,

A Confirmatory Phase 3 Mutlicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy of Topical HyBryte (Hypericin Sodium) and Visible-Light Activation for the Treatment of Cutaneous T-Cell Lymphoma (CTCL).

The purpose of this trial is to evaluate the safety and efficacy of 18 weeks of HyBryte (topical gel) treatment in combination with visible light therapy in subjects with cutaneous T-cell lymphoma when compared to placebo (no active ingredient). Cutaneous T-cell lymphoma (CTCL), of which the most common early stages are also known as mycosis fungoides (MF), is the most common type of T cell lymphoma. Participants will be enrolled in this trial for 30 weeks and will follow up at the clinic site every 4 weeks following the last trial treatment for a total of 12 weeks.

Participants will attend in person visits over 30 weeks. At different timepoints throughout the study participants will have their skin evaluated and photographed, have blood drawn, have an ECG done, and apply the study medication as directed by the study team.

Yes
 

Christopher Bazewicz
Samantha Gettle - at dermatologyclinicaltrials@pennstatehealth.psu.edu or 717-531-5136
Dermatology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT06470451
STUDY00025614
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Inclusion Criteria:
Participants must have a clinical diagnosis of CTCL (MF)
Participants must have a minimum of 3 evaluable, discrete lesions
Participants must be willing to follow the clinical protocol and voluntarily give their written informed consent

Exclusion Criteria:
Certain medications are not allowed to be used during the study; study coordinator will discuss.
Participants with extensive skin disease may not be eligible to participate; investigator will discuss during skin evaluation
Certain medical conditions may not be eligible to participate; study coordinator will discuss further.
Skin Conditions, Cancer
Experimental drug compared to a placebo/”sugar pill”
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Hershey, PA ,

Can more sleep improve pain responses, symptomatology, and regulation in college students?

This study is being done to find out how whether sleep duration is associated with pain responses and if a sleep intervention predicts a higher tolerance and a higher threshold for pain. This is a 21-day study. Participants will be asked to wear sleep-monitoring watches. Pressure pain and cold pain will be measured at study visits.

There will be four in-person visits. Height, weight, and blood pressure will be measured during each study visit. Participants will also be asked to complete surveys during each study visit.Pain will be measured during visits 2-4. Blood will be drawn during visits 2-4. Retinal images will be captured during visits 2-4. A Trail making test (a test for executive functioning) will be administered during visit 2-4. Participants will also be asked to provide screen shots of their phone screen use at visits 2-4.

$150

Yes
 

Anne-Marie Chang
moresleep@psu.edu 814-343-1928
Biobehavioral Health (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05816434
STUDY00022196
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Inclusion Criteria:
18 to 24 (inclusive) years of age at enrollment
Fluent English speaker and reader
Willing to refrain from initiating new therapeutic interventions (e.g., medication; behavioral) designed to target sleep or pain for the duration of study participation

Exclusion Criteria:
Diagnosed with a sleep disorder
Diagnosed with a pain disorder
Has experienced a cold-related injury or has any other nerve damage to the feet
Has a history of injury to any of the muscular measurement sites for pain (I.e. shoulder, jaw, forearm)
Diagnosed with hypertension or cardiovascular disease
Prevention
Not applicable
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State College, PA ,

EA8183 A Phase III Study of Early Intervention after RADICAl ProstaTEctomy with Androgen Deprivation Therapy with Darolutamide vs. Placebo in Men at Highest Risk of Prostate Cancer Metastasis by Genomic Stratification (ERADICATE) (PSCI# 21-122)

This study is being done to answer the following question:Will the addition of a new drug, darolutamide, to standard Androgen Deprivation Therapy (ADT) (a hormonal therapy that is a usual approach to treatment) after surgery cure more men with prostate cancer than using Androgen Deprivation Therapy alone?We are doing this study because we want to find out if this approach is better or worse than the usual approach for your prostate cancer. The usual approach is defined as care most people get for prostate cancer.

This study is being done to answer the following question:Will the addition of a new drug, darolutamide, to standard Androgen Deprivation Therapy (ADT) (a hormonal therapy that is a usual approach to treatment) after surgery cure more men with prostate cancer than using Androgen Deprivation Therapy alone?We are doing this study because we want to find out if this approach is better or worse than the usual approach for your prostate cancer. The usual approach is defined as care most people get for prostate cancer.

Yes
 

Joseph Miccio
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
Radiation Oncology (HERSHEY)
 

Male
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04484818
SITE00001026
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Inclusion Criteria:
Patient must be = 18 years of age.
Patient must have undergone a radical prostatectomy (RP) and must be preregistered to Step 0 of this study at least 6 weeks after but not more than 12 weeks after their radical prostatectomy.
Patient must not have any previous treatment with androgen deprivation therapy (ADT), chemotherapy, or other physician prescribed systemic therapy for treatment of their prostate cancer.
Patient must have an ECOG performance status of 0-2.

Exclusion Criteria:
Patient must not have pathologic evidence of pelvic lymph node involvement.
Patient must not have an uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association Class III and IV heart failure).
Cancer
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Hershey, PA ,

Comparing runners’ perception of their biomechanics through validation of RunScribe wearable technology in an outdoor environment.

Comparing runners' perceptions of their running gait biomechanics to actual mechanics using RunScribe wearable technology validated drone video capture and subsequent kinematic analysis in a natural outdoor running environment.

You will complete a survey and be asked to run a short distance on a track at your typical long distance pace while being filmed by a drone and while wearing a wearable RunScribe device on your shoe.

$50

Yes
 

Morgan Chambers
Morgan Chambers - at mchambers@pennstatehealth.psu.edu or 570-916-2739
Student Affairs (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00025813
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Inclusion Criteria:
18-50 years old
No prior or current running injuries in the past 3 months
Runs at least 15 km per week
Able to speak English

Exclusion Criteria:
Pre-existing cardiac condition
Current musculoskeletal injury
Currently under medical supervision or not cleared for running
Congenital or traumatic deformity resulting in altered bone alignment
No prior outdoor running experience
Sports Medicine
Not applicable
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Hershey, PA ,

Abstract Reasoning, Decision Making and Social Judgment as Markers of Frontotemporal Lobar Degeneration (FTLD) in Midlife in Juvenile Myoclonic Epilepsy (JME)

This study will look for emerging patterns of Frontotemporal Lobar Degeneration (FTLD), an early onset dementia, in Juvenile Myoclonic Epilepsy (JME). JME is a type of epilepsy that usually begins in adolescence and is known to be associated with disturbances of higher-level reasoning, mood and personality. JME patients are often managed by family physicians, rather than epilepsy specialists; with little known about aging with JME. We think that JME patients will demonstrate a pattern of executive dysfunction that is consistent with consensus criteria for FTLD, characterized by declines in abstract reasoning, judgment, and verbal problem solving, as well as behavior. We also think that there will be an inverse relationship between apathy and conscientiousness. We plan to obtain this information by formal cognitive testing of non-demented JME patients over a period of 2 years, at 6-month intervals, to look for progression of symptoms. Loved ones/caregivers will complete informant questionnaires about patient's mood and personality at the beginning of the study and at 6 month intervals throughout the duration of the 24 month study. We will also include loved one/caregiver cognitive testing at the beginning of the study to obtain healthy information for comparison to patient's findings. Our objectives are to characterize the executive functioning profiles of JME in midlife, taking into account cognition, mood, personality, nutritional status and lifestyle. The information obtained may contribute to better care of JME patients prior to midlife and throughout the course of aging.

Visit 1 for both patient and healthy caregiver participants will involve administration of the JME Virtual Visit Protocol via PSH Zoom. Participants will have completed their REDCap questionnaires prior to the visit to the research coordinator, who will be conducting the assessment. Visit 2-5 for patient participants will involve administration of the JME Virtual Visit Protocol via PSH Zoom. JME participation consists of 5 virtual visits with the study’s research coordinator, lasting approximately two hours each, for completion of standardized tests of problem-solving, thinking, and concentration, as defined above. Caregiver healthy control participation consists of 1 virtual visit with the study’s research coordinator, lasting approximately two hours, for completion of standardized tests of problem-solving, thinking, and concentration, as defined above. Remaining participation involves completion of objective inventories providing a caregiver perspective of the patient participant’s mood and behavior at 6-month intervals, within the 24 month time frame of the study.

No
 

Claire Flaherty
Meghan Grubb - at mgrubb1@pennstatehealth.psu.edu or 717-531-1804
Neurology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016306
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Inclusion Criteria:
JME in the absence of any other neurological condition
Primary language English
age 35 - 65
Mainstream Education
Loved one or caregiver to complete questionnaires

Exclusion Criteria:
Neurological conditions other than JME, including history of head trauma
Cardiac conditions affecting cognition
Other medical conditions affecting cognition,e.g.,hypoglycemia
Hospitalization for major depressive disorder within the past year
No available loved one or caregiver to complete questionnaires
Neurology, Mental & Behavioral Health, Language & Linguistics
Not applicable
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Angiotensin-(1-7) and Energy Expenditure in Human Obesity

We will investigate the effects of the hormone angiotensin-(1-7) on energy expenditure in patients with obesity.

This is an outpatient study that requires a screening visit, and if eligible, one study visit in the Clinical Research Center within the Penn State Health Milton S. Hershey Medical Center. The screening visit will take about one hour and includes a brief physical examination and medical history, urine pregnancy test if female and of childbearing potential, measurement of heart rhythm, collection of blood samples, and measurements of body composition. If eligible based on the results of the screening visit, participants will be invited to participate in one study visit that will take about four hours. Participants will complete food recall and activity questionnaires prior to the study visit and asked not to change eating or physical activity patterns. A urine pregnancy test will be given for females of childbearing potential. Participants will lie down on a bed and a catheter (small plastic tube) will be placed in a vein in each arm to draw blood samples and to give study medications. Equipment will then be placed to measure heart rate, blood pressure, breathing rate, and the amount of oxygen in the blood. After placing this equipment, participants will be allowed to rest for at least 20 minutes. Resting energy expenditure will then be measured by asking participants to breathe through a canopy placed over their head that is connected to a metabolic cart for 45 minutes. Blood samples will be taken to measure hormones influencing resting energy expenditure. Participants will then receive either angiotensin-(1-7) or normal saline (salt water) through the catheter in the arm for up to two hours. Angiotensin-(1-7) is a substance that the body produces naturally; however, in this form, it is considered experimental, which means the Food and Drug Administration has not approved it for this use. Participants will receive either angiotensin-(1-7) or normal saline. The treatment will be randomly assigned meaning that it is determined purely by chance, and neither the participant nor study investigators will know which treatment is received. Blood pressure, heart rate, breathing rate, and oxygen in the blood will be measured continuously while giving angiotensin-(1-7) or normal saline. During the last 45 minutes of the treatment, resting energy expenditure will be measured again and additional blood samples taken. Participants will also have the option of allowing for a small piece of fat to be taken from under the skin in the abdominal region (fat tissue biopsy). Participants will then be allowed to recover for at least 20 minutes and then all equipment will be removed. After the study visit, a nurse will contact participants to check on general well-being and answer any questions.

$25 per hour; additional $75 for fat tissue biopsy

Yes
 

Amy Arnold
Aimee Cauffman - at acauffman@pennstatehealth.psu.edu or 717-531-1617
Neuroscience and Experimental Therapeutics (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03777215
STUDY00009895
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Inclusion Criteria:
Men and women of all races
Age 18-60 years
Body mass index between 30-40 kg/m2
Capable of giving informed consent

Exclusion Criteria:
Age less than 18 years or greater than 60 years
Pregnant or nursing women
Current smokers
Type I or type II diabetes
History of major cardiovascular or cerebrovascular disease, immune diseases, impaired kidney or liver function
Heart & Vascular, Diabetes & Hormones
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Children’s reaction to multimodal cues in instructional materials

We aim to study how minoritized students perceive multimodal cues in instructional materials to improve STEM teaching for their STEM identity development.

To participate in the study at Penn State, students will be accompanied with their parent or a legal guardian. During the 40-minute session, participants will be asked to complete a brief survey and take part in an interview.

$50

Yes
 

Chanmin Kim
ChanMin Kim - at cmk604@psu.edu or 814-865-9919
Learning and Performance Systems (UNIVERSITY PARK)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00022788
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Inclusion Criteria:
Racially and/or ethnically minoritized students among 2nd through 5th graders
English is understood by prospective subjects or representatives

Exclusion Criteria:
Not racially and/or ethnically minoritized students among 2nd through 5th graders
English is not understood by prospective subjects or representatives
Education
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State College, PA ,

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis

A phase 3 clinical trial to investigate the effectiveness and safety of a study drug in subjects in Idiopathic Pulmonary Fibrosis

You will be required to attend 8 in-person visits at the Hershey Medical Center over the span of approximately one year. During the study you will have physical examinations, complete questionnaires, review your medical history and current medications, have vital signs and ECGs taken, have blood tests performed, complete pulmonary function testing, and potentially have a high resolution CT scan done. You will take the inhaled treprostinil or placebo daily at home throughout the study.

Yes
 

Rebecca Bascom
Timothy Sheehan - at tsheehan@pennstatehealth.psu.edu or 717-531-2925
Medicine: Pulmonary, Allergy and Critical Care (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04708782
STUDY00020859
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Inclusion Criteria:
At least 40 years of age
Diagnosed with Idiopathic Pulmonary Fibrosis

Exclusion Criteria:
Taking both Esbriet (pirfenidone) and Ofev (nintedanib)
Female participants who are pregnant or lactating
Receiving more than 10 L/min of oxygen supplementation at rest
Lung Disease & Asthma
Experimental drug compared to a placebo/”sugar pill”
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Hershey, PA ,

Prevalence of Avoidant Restrictive Food Intake Disorder (ARFID) traits among children and adolescents with Food Allergy

This study looks at understanding eating behaviors and attitudes toward food in children/adolescents. More specifically the study's goal is to compare those with and without food allergies to gain a better understanding of a possible underlying factor towards certain behaviors. Children and their caregivers will complete a survey composed of a short section on the child's medical history regarding allergies followed with questions in commonly used clinical assessments.

No
 

Jodi Brady-Olympia
Jodi Brady-Olympia - at jbradyolympia@pennstatehealth.psu.edu or 717-531-1383
Pediatrics: General Pediatrics (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00015831
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Inclusion Criteria:
Ages 8-17

Exclusion Criteria:
Age under 8 years old
Age 18 years or older
Intellectual disability preventing comprehension of questions
Child and/or caregiver unable to respond to English-language questionnaire
Children's Health, Allergies, Food & Nutrition
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Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony

Anxiety can emerge as early as pre-school age (4-7) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.

Participation requires three steps; a remote video session with the primary parent, an in-lab visit scheduled with the primary parent and child, and then an additional set of questionnaires given to the secondary caregiver.The remote session consists of obtaining consent, 2 questionnaires, and a clinical interview. The in-lab visit typically lasts about 2-3 hours, consisting of two parent-child activities and several child-only activities. Participants will be asked to wear mobile eye-tracking glasses and special caps used to measures brain activity during some of the tasks.

$125, $100 for the primary parent/or child and $25 for secondary parent

Yes
 

Koraly Perez-Edgar
Kimberly Labra - at kml7098@psu.edu or 814-867-2322
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00017857
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Inclusion Criteria:
Parents/Caregivers over 18
Children ages 4 to 6

Exclusion Criteria:
major medical illness
Children less than age 4 or over age 6
Children's Health, Mental & Behavioral Health
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State College, PA ,

Genomic Profiling of Urothelial Cancers Study

The objective of this protocol is to study urothelial cancer with detailed health history, tumor and/or normal tissues available for genomic sequencing to study cancers in the bladder, upper urinary tract, and urethra. There will be 3 groups of subjects in this study:1)Urothelial cancer patients receiving care at Penn State Health2)Relatives of patients with urothelial cancer3)High risk-cohort of individuals with family history of urothelial cancers or inherited cancer syndromes (such as Lynch syndrome) candidates for urothelial cancer screening evaluation

All subjects will be asked to fill out questionnaires to assess risk factors for urinary cancer and document family history of cancer. You will be asked to provide a blood sample and urine sample for genetic testing. Patients with urothelial cancer will be asked to allow us to test leftover tissue from a past or future biopsy to test cancer and/or normal cells for certain mutations. We may also ask you for a saliva sample, cheek swab, skin biopsy, or nail clippings for comparison.

Yes
 

Hong Truong
UrologyResearch@pennstatehealth.psu.edu
Urology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00021468
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Inclusion Criteria:
personal or family history of urothelial cancer
personal or family history of bladder cancer

Exclusion Criteria:
Cancer other than urothelial cancer
Cancer
Not applicable
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Hershey, PA ,

Towards Efficient Adaptive Federated Learning: Algorithms, Theories, and Applications

The broad goal of this project is to provide both theoretical and algorithmic solutions for efficient adaptive federated learning, as well as build practical adaptive federated learning systems for real-world applications.

Each participant carrying or wearing a smart device will conduct six activities, including (a) Wiping the whiteboard; (b) Walking; (c) Moving a suitcase; (d) Rotating the chair; (e) Sitting; (f) Standing up and sitting down. We will collect nine signals from each smart device, including three axes of the accelerometer, three axes of the gyroscope, and three axes of the magnetometer.

$20

Yes
 

Jinghui Chen
Jinghui Chen - at jzc5917@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00024201
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Inclusion Criteria:
The proposed study will involve adults no less than 18 years old.
Efforts will be made to include both men and women.
No Vulnerable populations will be included.

Exclusion Criteria:
Vulnerable populations such as pregnant women, children, cognitive impaired adults, and prisoners.
People who are less than 18 years old.
Not applicable
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State College, PA ,

Multidisciplinary Collaboration as a Bridge to the Ethical Collection of Patient-level Data on Social Determinants of Health (SDoH)

The purpose of this study is to create a tool that will evaluate a patients social determinants of health, which is the environment in which someone is born, works and lives. This tool could provide information to physicians that could help the patient avoid negative health outcomes.

Yes
 

Susan Veldheer
Brianna Hoglen - at bhoglen@pennstatehealth.psu.edu or 717-531-0003, ext=321654
Family and Community Medicine (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00012893
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Inclusion Criteria:
Adult 18+
Patient at Penn State Health OR Community Member
Can read and write in English

Exclusion Criteria:
Inability to make their own decisions/consent
prisoner
Brain Injury
Education
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Harrisburg, PA ,
Hershey, PA ,

Longitudinal Associations Between Food Insecurity, Diet, Mental Health, Sleep and Academic Outcomes in College Students

This is a questionnaire study that seeks to discover the prevalence of food insecurity at PSU's University Park campus over the course of a semester and the relationship between long-term food insecurity and academic outcomes, as mediated by mental health and sleep outcomes.

No
 

Muzi Na
Kiara Smith - at kxs782@psu.edu
Nutritional Sciences (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015990
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Inclusion Criteria:
Must be a Penn State student at University park
Must be in their 2nd semester during Spring 2021
Must have internet access
Must be at least 18 years old
Must not have children or other dependents

Exclusion Criteria:
Has diagnosed learning or mental disabilities
Has diagnosed mental disorders
Is unable to read, write or understand English fluently
Food & Nutrition, Sleep Management, Mental & Behavioral Health
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Women, Opioid Use Disorder, and Criminal Justice: A Qualitative Study

Opioid-related overdose deaths and incarceration rates have skyrocketed and have disproportionately affected women. Despite having a higher burden of substance use disorders and HIV/AIDS than criminal justice-involved (CJI) men, CJI women are less likely to have access to substance use and HIV treatment. This qualitative study will conduct in-depth interviews with CJI women, MAT providers, and criminal justice professionals to identify facilitators and barriers to illicit opioid use cessation and related issues among CJI women.

No
 

Abenaa Jones
Abenaa Jones - at avj5462@psu.edu
Human Development and Family Studies (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00018974
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Inclusion Criteria:
women
substance use
opioid use
criminal justice
drug treatment

Exclusion Criteria:
Younger than 18 years of age
Addiction & Substance Abuse, Mental & Behavioral Health, Women's Health
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Errorless and error-based syntactic priming effects in neurologically intact older adults

This research study is being done to understand how different techniques for practicing sentences are affected by healthy aging. This will help us create better language therapy for people with aphasia.

There will be one visit. It can be in-person or over Zoom. We will ask you to fill out a questionnaire about yourself, complete a brief cognitive assessment, and complete a sentence production task. This visit should only last about 90 minutes.

up to $15

No
 

Chaleece Sandberg
Parisa Osfoori - at pvo5112@psu.edu
Communication Sciences and Disorders (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00024639
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Inclusion Criteria:
at least 40 years of age
native speaker of English
at least high school education
normal or corrected-to-normal vision and hearing

Exclusion Criteria:
history of neurodegenerative disorder (e.g., Alzheimer's)
history of acquired neurological disorder (e.g., stroke)
history of developmental neurological disorder (e.g., dyslexia, autism)
history of psychiatric disorder (e.g., schizophrenia)
active medical condition (e.g. cancer) or medications that could affect cognition (e.g., opiods)
Language & Linguistics
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The Effects of Healthy Diets with Plant Oils on Heart and Metabolic Health

The purpose of this study is to assess if a healthy diet containing cottonseed oil improves markers of heart and metabolic health compared to healthy diets containing other commonly consumed plant oils. Participants will be asked to consume three different healthy diets containing plant oils for 28 days each, with a minimum 1-month break between the three diets. Measurements of blood markers (sugar, insulin, cholesterol), blood pressure, and heart health, will be done at the start of the study and the end of each diet period.

In this study, you will be asked to consume three different diets for 28 days each. The diets will be provided and include 3 meals, 2 snacks and beverages daily. These diets will meet your energy and nutrient needs. You will be asked not to eat any foods outside of what is provided by the study. You will have a minimum 1-month break between the three diets. Testing will be conducted on two consecutive days at the start of the study, and the end of each of the three diet periods (a total of 8 testing days). For these visits, you will need to fast for 12 hours prior and avoid alcohol for 48 hours prior. At these visits, we will take a blood draw, measure your body weight, and perform non-invasive tests to assess your vascular health.

500

Yes
 

Kristina Petersen
Janhavi Damani - at dchlab@psu.edu or 814-863-8056
Nutritional Sciences (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT06216678
STUDY00023998
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Inclusion Criteria:
Age: 25-60 years
BMI: 25-40 kg/m2
LDL cholesterol: 100-190 mg/dL

Exclusion Criteria:
Diagnosis of heart disease, stroke, kidney or liver disease
Current use of tobacco-containing products or (≤6 months) cessation
Pregnant or nursing individuals
Allergy to study foods
Food & Nutrition, Heart & Vascular
Not applicable
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State College, PA ,

Applying Social cognitive theories of learning to Adaptive Learning

In this work, we wish to explore how social learning can be promoted in the case of adaptive learning.

No
 

Sanjana Gautam
Sanjana Gautam - at sqg5699@psu.edu
Division of Graduate Studies (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00017614
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Inclusion Criteria:
Above 18 years of age

Exclusion Criteria:
Below 18 years of age
Education
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