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442 Study Matches

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction

This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies with a small number of people with large hemispheric infarction (LHI). These studies suggested that the study drug was safe, did not cause serious side effects or discomfort, and may reduce brain swelling, disability, and death in subjects with LHI. In this study, we want to investigate the study drug in a larger number of subjects (hundreds) to know more about it. LHI is a type of stroke. An ischemic stroke occurs when blood flow to parts of the brain is blocked, such as by a blood clot. This can cause damage to the brain. In LHI a large portion of the brain is damaged. People who have LHI can develop swelling of the brain called cerebral edema, which can worsen the symptoms and outcomes of LHI. Currently, there are no medications available to specifically reduce brain swelling caused by LHI. In this study, we want to investigate how well the study drug works to improve functional outcomes (the ability to do normal daily activities, such as walking and getting dressed) in subjects with LHI. This study will also look at the long-term effects of the study drug over time and see how safe the study drug is.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02864953
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Inclusion Criteria:
A clinical diagnosis of acute ischemic stroke in the MCA territory within 10 hours of symptom onset
Aged 18 to 85 years old, inclusive, at the time of informed consent
Screening NIHSS ≥10
Exclusion Criteria:
In the judgment of the Investigator, the subject is likely to have supportive care withdrawn in the first day
Commitment to decompressive craniectomy (DC) prior to enrollment
Evidence (clinical or imaging) of concurrent infarction in the contralateral hemisphere deemed by the Investigator to be sufficiently serious so as to affect functional outcome
Clinical signs of herniation and/or loss of other brain stem reflexes, attributable to edema or herniation according to the Investigator’s judgment
Brain hemorrhage (other than small petechial/punctate hemorrhages) on NCCT/MRI
Neurology
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Hershey, PA

Immersive Virtual Reality Storm Surge: Scale and Risk Perception

Evaluating if an immersive virtual reality experience of storm surge flooding gives people an understanding of the scale of the flooding and increases their risk perception of such flooding compared to a non-immersive desktop experience.
Mark Simpson at marksimpson@psu.edu or 575-491-5512
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Normal or corrected-to-normal vision
English-speaking
Exclusion Criteria:
Under age 18
Education
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State College, PA

Creative Thinking and Problem Solving

This is a behavioral study that will examine cognitive processes relevant for creative thinking. Participants will be asked to complete a series of cognitive tasks and self-report measures on a computer.
James Lloyd-Cox at jll487@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years or older
They must consent to participate in research
Healthy volunteers

Native English Speakers
Exclusion Criteria:
Cannot be non-native English speakers
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State College, PA

Efficacy of Virtual Reality Exposure Therapy Scripts for Social Phobia

This research is conducted to test if virtual reality technology is effective to help people face their social fears and promote the use of adaptive social skills in various settings. You will be immersed in a range of virtual reality environments and work with a research therapist to learn certain skills, such as managing fears of negative evaluation during job interviews, and interacting with peers in common social settings (e.g., classrooms, cafeterias).
Hani Zainal at nvz5057@psu.edu or 814-863-0115
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Be at least 18 years old
Experiencing significant social anxiety
Able to read, write, and understand English
Not struggling with ongoing ongoing alcohol or substance use
Not actively suicidal
Exclusion Criteria:
Not interested in engaging in mental health treatment
Not socially anxious
Men's Health, Mental & Behavioral Health, Women's Health
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State College, PA

Story Circles as a Methodology: Exploring Illness Perceptions in Advanced Heart Failure

We will utilize Story Circles with persons living with advanced heart failure to explore their experiences, their illness perceptions, and how these perceptions might influence goals of care and decision making. There is a gap in our current understanding of how persons living with an advanced life-limiting illness such as heart failure perceive their illness and how this might influence decision-making. New knowledge regarding a person’s illness perceptions has important implications for future work including goals of care conversations and decision making for heart failure throughout the illness trajectory and especially at the end of life.
Lisa Kitko at lkitko@psu.edu or 814-863-2228
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years of age or greater
Diagnosis of heart failure
English speaking
Exclusion Criteria:
Unable to provide informed consent
Heart & Vascular
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Altoona, PA
Hershey, PA
State College, PA

Site for Cabazitaxel with Abiraterone versus Abiraterone alone Randomized Trial for Extensive Disease following Docetaxel: the CHAARTED2 Trial

To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel and ADT for HSPC can improve PFS compared to abiraterone acetate alone.
Kathleen Rizzo at kar23@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03419234
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Inclusion Criteria:
Age ≥ 18 years
Histologically confirmed diagnosis of prostate cancer (adenocarcinoma of the prostate).
Previous chemotherapy with at least 3 cycles of docetaxel for hormone-sensitive metastatic prostate cancer.
Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (CT/MRI of abdomen/pelvis, bone scintigraphy or NaF PET/CT).
Ability to swallow abiraterone acetate tablets as a whole.
Exclusion Criteria:
Any prior chemotherapy or AR-directed therapy for CRPC, (e.g. docetaxel, cabazitaxel, mitoxantrone, abiraterone
Pure small cell or other variant (non-adenocarcinoma) prostate cancer histology for which treatment with abiraterone would not be considered appropriate.
Patients may not be receiving other therapeutic investigational agents or be receiving concurrent anticancer therapy other than standard androgen deprivation therapy.
Any medical condition for which prednisone (corticosteroid) is contraindicated.
Active infection requiring treatment with antibiotics.
Cancer
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Hershey, PA

Understanding the Relationship between Education and Well-being among College Students with Disabilities

The purpose of the study is to gain an understanding of students’ experiences in college and their engagement help-seeking and healthy behaviors. Participation in the study involves completing a brief online-survey on Qualtrics, which we anticipate will take approximately 20 minutes to complete.
Amber O'Shea at amo5208@psu.edu or 814-867-5721
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Currently enrolled as a college student
18 years of age or older
Capable of providing informed consent
Diagnosis of a disability
Able to understand written English
Exclusion Criteria:
Adults unable to provide legal consent
Individuals who are not yet legal adults
Pregnant women
Prisoners
Education, Mental & Behavioral Health, Women's Health
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A more naturalistic interaction: using back-channeling in smart-speakers to indicate active listening

In this project, we aim to extend the capabilities of smart-speakers (such as Amazon Alexa, Google Home, Siri, etc.) to support more engaging interactions with their users. Specifically, we would like to make the future of smart-speakers more conversational. One of the key aspects in developing a conversation is to be an active listener; showing interest in the speaker and allowing them to extend their turn in talk. In this study we investigate how smart-speakers can become better listeners by incorporating some of the human-human conversational features of active listening. Our question is, how can smart-speakers extend the users' turn in talk by being better listeners?
Nasim Motalebi at nfm5140@psu.edu or 814-753-2081
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years of age and older
English speaking individuals
Exclusion Criteria:
under 18 years old
non english-speaking individuals
Mental & Behavioral Health
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State College, PA

A phase III, multicenter, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, early breast cancer (New Adjuvant TriAl with Ribociclib [LEE011]: NATALEE).

This is a drug study that will examine the drug Ribociclib with endocrine therapy versus just endocrine therapy in patients with early breast cancer.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03701334
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Inclusion Criteria:
Patient with histologically confirmed unilateral primary invasive adenocarcinoma of the breast with a date of initial cytologic or histologic diagnosis within 18 months prior to randomization
Patient has breast cancer that is positive for ER and/or PgR
Patient has HER2-negative breast cancer defined as a negative
Patient has available archival tumor tissue from the surgical specimen, for submission to a central laboratory.
If indicated, patient has completed adjuvant and/or neoadjuvant chemotherapy according to the institutional guidelines
Exclusion Criteria:
Patient has received any CDK4/6 inhibitor
Patient has received prior treatment with tamoxifen, raloxifene or AIs
Patient has received prior treatment with anthracyclines at cumulative doses of 450 mg/m² or more for doxorubicin, or 900 mg/m² or more for epirubicin.
h a known hypersensitivity to any of the excipients of ribociclib and/or ET (
Patient with distant metastases of breast cancer beyond regional lymph nodes
Cancer
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Hershey, PA

Site for EA9161: A Randomized Phase III Study of the addition of Venetoclax to Ibrutinib and Obinutuzumab versus Ibrutinib and Obinutuzumab in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)

The is a drug study to compare the progression free survival of the three drug combination Ibrutinib-Obinutuzumab-Venetoclax (IOV) to Ibrutinib-Obinutuzumab (IO) in untreated CLL patients younger than 70 years of age.
Michelle Stojanovic at mstojanovic1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03701282
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Inclusion Criteria:
Diagnosis of CLL according to the NCI/IWCLL criteria or SLL according to the WHO criteria
Negative FISH analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy
Age ≥ 18 years and < 70.
ECOG performance status between 0-2.
Life expectancy of ≥ 12 months.
Exclusion Criteria:
No deletion of 17p13 on cytogenetic analysis by FISH
No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment.
No current use of corticosteroids.
No previous autoimmune complications
No other active primary malignancy
Cancer
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Hershey, PA

Storytelling on Snapchat

This study will examine via ethnographic observation the Story feature on social media. Participants will be asked to provide their Snapchat or Instagram username and must be willing to let the researcher observe the Stories that they post. The primary aims are to illuminate how and why people are using the Story feature on social media, and to analyze how this feature is changing how we relate to and understand the world around us.
Michael Krieger at mlk75@psu.edu or 646-430-0117
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
User of the Story feature on Snapchat or Instagram
At least 18 years old
Exclusion Criteria:
Anyone under the age of 18 years old
Non users of social media
Education, Mental & Behavioral Health, Language & Linguistics
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Site for A RANDOMIZED PHASE III DOUBLE BLINDED PLACEBO CONTROLLED TRIAL OF ASPIRIN AS ADJUVANT THERAPY FOR HER2 NEGATIVE BREAST CANCER: THE ABC TRIAL.

This is a drug study with a primary outcome of testing aspirin as therapy versus a placebo pill for patients for breast cancer.
Lea Russell at lmay1@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02927249
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Inclusion Criteria:
Histologic documentation of women or men with HER2 negative breast carcinoma and free of recurrence.
Prior adjuvant treatment with chemotherapy and/or endocrine therapy, as determined by the treating physician, is allowed.
Age > 18 and < 70 years of age.
ECOG performance status 0-2.
Patients with a prior history of gastric/duodenal ulcers documented on endoscopy can be enrolled as long as the ulcers did not cause bleeding requiring a blood transfusion/major intervention.
Exclusion Criteria:
No history of GI bleeding requiring a blood transfusion, endoscopic or operative intervention.
No history of any prior stroke (hemorrhagic or ischemic).
No concurrent anticoagulation with warfarin, heparin/heparin analogues, clopidogrel, direct thrombin inhibitors, or direct factor XA inhibitors.
No history of atrial fibrillation or myocardial infarction.
No history of grade 4 hypertension, defined as hypertension resulting in lifethreatening consequences
Cancer
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Hershey, PA

Coparenting, Infant Sleep, and Infant Development: An Intervention Study

This application proposes a randomized clinical trial (RCT) to evaluate the effects of a sleep-enhanced adaptation of an evidence-based transition-to-parenting coparenting intervention program [Family Foundations - FF). The study has three arms. In one arm, families will experience FF as originally formulated; in the second, families will receive an adapted FF that emphasizes coparenting in infant sleep contexts; the third arm will serve as controls. Assessments of coparenting and parenting in infant sleep contexts, parental adjustment to infant sleep behavior, choices about sleep arrangements, infant and parent sleep quality, and infant socio-emotional functioning, will serve as outcomes.
Morgan Loeffler at FF@psu.edu or 717-695-7050
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03187561
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Inclusion Criteria:
Parents must live together
Parents must be expecting their first baby together
We must start working with the couple before the baby is born
Parents must be 18 years or older
Families who can speak and understand English
Exclusion Criteria:
Single-parent families
Families with more than one-child
Familes who cannot speak or understand English
Families in which one parent is under the age of 18
Pregnancy & Infertility, Sleep Management, Women's Health
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Carlisle, PA
Harrisburg, PA
Hershey, PA

Walking through the forests of the future: Using data-driven iVR to visualize forests under climate change

We used a combination of ecological modeling, procedural modeling, and virtual reality to provide an embodied experience of “walking through the forests of the future”. This study will provide empirical evidence of the effectiveness of this immersive experience based on users’ feedbacks on different kinds of tools we developed.
Jiawei Huang at jzh87@psu.edu or 734-355-5327
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
forestry or climate science related majors (include but not limited to agricultural sciences, environmental resources management, forest ecosystem management, plant science, ecology, biology, meteorology and atmospheric science)
undergraduate or graduate students at Penn State University who are older than 18.
participants should be healthy (without contagious disease)
Exclusion Criteria:
people under 18
people who are cognitively impaired
people who have contagious disease
Education, Language & Linguistics
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Study Locations

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State College, PA

"Alexa, I’m in pain! "A Real-Time Mindfulness Intervention to Control Pain: Delivery Through a Conversational Agent

We are interested in learning about people’s experiences with using the Amazon Alexa for delivery of a real-time mindfulness intervention to help with chronic pain management. Participation will include a free day-long introductory mindfulness training followed by daily use of mindfulness practices using the Amazon Alexa to establish a habit of use. The participants will use our developed Amazon Alexa app ("skill") and provide assessments. We will ask participants to complete short daily surveys and a follow-up interview.
Sebrina Doyle at sld40@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Individuals who had some experience with chronic pain over the last 6 months
Living in homes with internet access
Willing to use a smart-home device (Amazon Alexa)
Have access to a smart phone
Read, write, and speak English
Exclusion Criteria:
Under 18 years old
Major mental health issue that is not currently under advisement of a doctor/therapist
Actively struggling with addiction to substances or newly in recovery
Participants who currently report using mindfulness practices more than 1x a month
Pain Management
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State College, PA

Describing your voice: Viewpoints from pre-professional voice users

The purpose of this study is to conduct semi-structured interviews with students at Penn State who are working towards degrees in fields that require a high vocal demand (e.g. teachers, lawyers, singers, actors, etc). The purpose is to learn more about what students think about their voice, what they know about protecting their voice, and what they would do if they had a voice disorder. This information can be used to design interventions and preventative outreach programs for these students.
Nicole Etter at oppal@psu.edu or 814-863-2021
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18 years and older
Working towards a degree in a field requiring high vocal demand (e.g. future teachers, lawyers, voice performers including singers and actors)
Exclusion Criteria:
Currently being treated for a voice disorder
Prevention, Education, Language & Linguistics
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Randomized trial of low nicotine cigarettes plus electronic cigarettes in smokers

This study will examine the health effects of lowering the nicotine content in cigarettes while having access to an electronic cigarette.
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04058717
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Inclusion Criteria:
Ages 21-70
Smoke 5 or more cigarettes per day
Must be willing to both switch to a different type of cigarette and try an electronic cigarette
No serious quit attempt or use of smoking cessation medication in the past 30 days
Meet diagnostic criteria for current or lifetime mental health condition
Exclusion Criteria:
Women who are pregnant, nursing, or trying to become pregnant
Any known allergy to propylene glycol or vegetable glycerin
History of difficulty providing blood samples
Other member of the household currently participating in the study
Unstable or significant medical condition in the past 3 months
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Mental & Behavioral Health
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Hershey, PA

Site for A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety and Efficacy of Risankizumab in Adult Subjects with Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa: Phase 2 Subject and Investigator Blinded, 68 week study with phone call 20 weeks after last dose. Hidradenitis Suppurativa (HS) is a chronic recurrent and debilitating skin condition that typically presents with deep and painful lesions. The most common areas affected are the armpits, the groin, and the anus and genitals area. The purpose of the study is to find out if risankizumab is beneficial and well tolerated in patients with HS. Each subject will be assigned to 1 of 3 treatment groups, reassigned to a different treatment at week 16, and then receive risankizumab at week 20.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03926169
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Inclusion Criteria:
Moderate to Severe HS for at least 1 year
HS lesions in at least 2 affected areas
Willing to follow all study instructions
Exclusion Criteria:
Certain treatments for HS are not allowed; coordinator will discuss specific treatments
unable or unwilling to return to the study site for all study visits and tests.
Known Hepatitis B, Hepatitis C, or HIV infections
Skin Conditions
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Hershey, PA

Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities

We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year
Exclusion Criteria:
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate-to-Severe Crohn's Disease

This study is for patients with moderate to severely active Crohn's disease to measure how effective and safe an experimental medication is in treating this condition.
Laurie Peiffer at lpeiffer@pennstatehealth.psu.edu or 717-531-5226
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03599622
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Inclusion Criteria:
moderate to severe crohn's disease, 3 months
failed prior treatment
Exclusion Criteria:
severe or fulminant colitis requiring surgery
presence of stoma, gastric pouch
prior bowel resection, 6 months
bleeding disorders
cancer < 5 years
Digestive Systems & Liver Disease
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Hershey, PA

Assessing cognitive and psychosocial mechanisms of Useful Field of View cognitive training using ecological momentary assessment

We are interested in how brain games impact everyday life in healthy older adults. Participants will play 20 hours of brain games on a study-provided laptop, and we will examine how the brain games impact everyday life. This study will be performed remotely in participants homes using study-provided laptops. Some participants may also participate in 2 optional visits with brain MRI scans at Penn State University and at home sleep monitoring.
Michelle Huerbin at mlh5955@psu.edu or 814-865-4773
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT00000000
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Inclusion Criteria:
65 or older
no diagnosis of dementia
available for 6 months
Exclusion Criteria:
64 or younger
dementia or motor movement disorder diagnosis
cognitive training within past 2 years
Mental & Behavioral Health
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Cardio-metabolic effects of diets including pecans

The purpose of the study is to examine how the inclusion of 2 oz./day of pecans into a typical American diet and a healthy diet affect risk factors for heart disease and diabetes.
Philip Sapp at pzs5199@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 25-70 years
BMI 25-40 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Not willing to consume all meals and snacks provided for the study
Food & Nutrition
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State College, PA

A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 2-Arm, Efficacy, and Safety Study in Prurigo Nodularis with Nalbuphine ER Tables for Pruritus Relief Through Itch Scratch Modulation (PRISM Study)

Prurigo Nodularis: Phase 2b/3 Subject and Investigator Blinded, 56 Week study. Oral medication taken twice daily, Males/Females 18 years and older with Prurigo Nodularis Prurigo Nodularis (PN) is a skin disease that causes hard, itchy lumps (nodules) to form on the skin. The itching (pruritus) can be intense, cause people to scratch themselves to the point of bleeding or pain. The goal of this study is to evaluate the change of itch with using Nalbuphine ER.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03497975
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Inclusion Criteria:
PN involving 2 affected areas
Willing to follow all study directions and attend appointments
Exclusion Criteria:
PN affecting only 1 part of the body
Certain diagnosis associated with PN are not allowed, coordinator will discuss specifics
Skin Conditions
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Hershey, PA

Understanding the effect of drivers’ profile information on riders’ feedback in ride-sharing context

This study aims to understand ways to affect how riders perceive and provide feedback to drivers through technology intervention. Particularly, we investigate how presenting drivers’ personal profile under different trip conditions may lead to differences in the ways riders may provide feedback. We hypothesize that riders will provide positive feedback when provided drivers’ personal information when the trip goes well, and that riders will provide less negative feedback when provided drivers’ personal information when the trip goes bad due to uncontrollable reasons.
Ning Ma at nzm37@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Taken at least 10 Uber/Lyft ride in the last 12 months.
You are willing to share several of your past Uber/Lyft trip records in the app with us.
Exclusion Criteria:
You are a current or past employee with one of the ride-sharing corporations (Uber/Lyft)
Education
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State College, PA

A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System Kit in Subjects with Hypertension

The purpose of this study is to evaluate the safety and effectiveness of renal denervation while still on blood pressure medications. Renal denervation is the destruction of nerve fibers that run along the kidney blood vessels. This causes an interruption of nerve signals that may cause high blood pressure. Therefore, the effectiveness of the study catheter and the alcohol (Peregrine Kit) will be assessed by how well the treatment reduces blood pressure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02910414
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Inclusion Criteria:
age 18-80
Have high blood pressure despite taking blood pressure medicine
You have not donated a kidney
Exclusion Criteria:
You have had removal of a kidney or kidney transplant
You have type 1 diabetes or severe type 2
Have severe untreated obstructive sleep apnea
Bleeding disorder
Heart & Vascular
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Hershey, PA

The Daily Reflections Study

This 14-day daily diary study is being conducted to better understand how young adults' thoughts and feelings about their bodies influence their health behaviors, and how their daily experiences and characteristics contribute to their health behaviors. Participants will be asked to complete a 10-20 minute baseline survey and a brief (5-8 minutes) daily survey each day for 14 consecutive days. Surveys will include questions about participants' mental and physical health, emotions, relationships, health behaviors, thoughts, and experiences.
Anna Hochgraf at akh7@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 18-25 years
Enrolled in undergraduate degree program at Penn State's University Park Campus
Access to internet between 8:00 AM and 2:00 PM
Proficient in English language
Living in University Park or State College this semester
Exclusion Criteria:
Not between ages 18-25 years
Not enrolled in undergraduate degree program at Penn State's University Park campus
No access to internet between 8:00 AM and 2:00 PM
Not proficient in English language
Not living in University Park or State College this semester
Smoking, Vaping, Nicotine and Tobacco, Mental & Behavioral Health, Women's Health
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EXALT: EXercise Attenuates Liver Tumors Trial

Our goal is to better understand how exercise impacts patients with liver cancer in order to identify treatments that can improve outcomes and access to liver transplantation.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03979547
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Inclusion Criteria:
Adults age >=18 or <70 years
Liver cancer diagnosis (HCC)
absence of all detectable cancer after your treatment
Exclusion Criteria:
active heart problems
BMI <18 or >45 kg/m2
Severe medical or mental illness
Cancer
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Hershey, PA

Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.
Amanda Miller at aross1@pennstatehealth.psu.edu or 717-531-7676
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04137757
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Inclusion Criteria:
Men and women of all races
18- 60 years old
Previously Diagnosed with POTS or healthy people without chronic illness
Capable of giving informed consent
Exclusion Criteria:
Age <18 years or >60 years
Pregnant or breastfeeding women
Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration)
Taking stimulant medications within the past 3 months as these may alter cognition
Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal)
Heart & Vascular, Neurology
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Hershey, PA

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Ravulizumab in Complement-Inhibitor-Naïve Adult Patients With Generalized Myasthenia Gravis

The primary purpose of this phase 3 clinical trial is to evaluate the safety and efficacy of ravulizumab for the treatment of participants with generalized myasthenia gravis (gMG).
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03920293
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Inclusion Criteria:
Diagnosed with myasthenia gravis for at least 6 months
Myasthenia Gravis Foundation of America (MGFA) classification: Class II to IV
Weigh at least 40 kg (about 88 lbs)
Exclusion Criteria:
History of thymectomy (removal of the thymus gland) within 12 months
Active or untreated thymoma (tumor of the thymus gland)
History of meningococcal infection
HIV infection
Pregnancy
Neurology
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Hershey, PA

Collaborative Research: Measuring and Enhancing Scientific Creative Thinking for STEM Education and Research: Classroom-Aligned Assessment and Network Neuroscience-Based Mechanisms

The project is interested in understanding how the brain supports creative thinking in the context of solving scientific problems. During functional magnetic resonance imaging (fMRI) and behavioral experiments, participants will be presented with open-ended scientific questions and asked to produce responses.
Brendan Baker at brendan.baker@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Over 18 in age
English is first language
Right-handed
No history of neurological injury or disease
Under 300 lbs in weight
Exclusion Criteria:
Claustrophobic
Taking medication that affects brain or blood flow
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Study Locations

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State College, PA