A clinical diagnosis of acute ischemic stroke in the MCA territory within 10 hours of symptom onset
Aged 18 to 85 years old, inclusive, at the time of informed consent
Screening NIHSS ≥10
In the judgment of the Investigator, the subject is likely to have supportive care withdrawn in the first day
Commitment to decompressive craniectomy (DC) prior to enrollment
Evidence (clinical or imaging) of concurrent infarction in the contralateral hemisphere deemed by the Investigator to be sufficiently serious so as to affect functional outcome
Clinical signs of herniation and/or loss of other brain stem reflexes, attributable to edema or herniation according to the Investigator’s judgment
Brain hemorrhage (other than small petechial/punctate hemorrhages) on NCCT/MRI

Normal or corrected-to-normal vision
English-speaking
Under age 18

18 years or older
They must consent to participate in research

Native English Speakers
Cannot be non-native English speakers

Be at least 18 years old
Experiencing significant social anxiety
Able to read, write, and understand English
Not struggling with ongoing ongoing alcohol or substance use
Not actively suicidal
Not interested in engaging in mental health treatment
Not socially anxious

18 years of age or greater
Diagnosis of heart failure
English speaking
Unable to provide informed consent

Age ≥ 18 years
Histologically confirmed diagnosis of prostate cancer (adenocarcinoma of the prostate).
Previous chemotherapy with at least 3 cycles of docetaxel for hormone-sensitive metastatic prostate cancer.
Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (CT/MRI of abdomen/pelvis, bone scintigraphy or NaF PET/CT).
Ability to swallow abiraterone acetate tablets as a whole.
Any prior chemotherapy or AR-directed therapy for CRPC, (e.g. docetaxel, cabazitaxel, mitoxantrone, abiraterone
Pure small cell or other variant (non-adenocarcinoma) prostate cancer histology for which treatment with abiraterone would not be considered appropriate.
Patients may not be receiving other therapeutic investigational agents or be receiving concurrent anticancer therapy other than standard androgen deprivation therapy.
Any medical condition for which prednisone (corticosteroid) is contraindicated.
Active infection requiring treatment with antibiotics.

Currently enrolled as a college student
18 years of age or older
Capable of providing informed consent
Diagnosis of a disability
Able to understand written English
Adults unable to provide legal consent
Individuals who are not yet legal adults
Pregnant women
Prisoners

18 years of age and older
English speaking individuals
under 18 years old
non english-speaking individuals

Patient with histologically confirmed unilateral primary invasive adenocarcinoma of the breast with a date of initial cytologic or histologic diagnosis within 18 months prior to randomization
Patient has breast cancer that is positive for ER and/or PgR
Patient has HER2-negative breast cancer defined as a negative
Patient has available archival tumor tissue from the surgical specimen, for submission to a central laboratory.
If indicated, patient has completed adjuvant and/or neoadjuvant chemotherapy according to the institutional guidelines
Patient has received any CDK4/6 inhibitor
Patient has received prior treatment with tamoxifen, raloxifene or AIs
Patient has received prior treatment with anthracyclines at cumulative doses of 450 mg/m² or more for doxorubicin, or 900 mg/m² or more for epirubicin.
h a known hypersensitivity to any of the excipients of ribociclib and/or ET (
Patient with distant metastases of breast cancer beyond regional lymph nodes

Diagnosis of CLL according to the NCI/IWCLL criteria or SLL according to the WHO criteria
Negative FISH analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy
Age ≥ 18 years and < 70.
ECOG performance status between 0-2.
Life expectancy of ≥ 12 months.
No deletion of 17p13 on cytogenetic analysis by FISH
No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment.
No current use of corticosteroids.
No previous autoimmune complications
No other active primary malignancy

User of the Story feature on Snapchat or Instagram
At least 18 years old
Anyone under the age of 18 years old
Non users of social media

Histologic documentation of women or men with HER2 negative breast carcinoma and free of recurrence.
Prior adjuvant treatment with chemotherapy and/or endocrine therapy, as determined by the treating physician, is allowed.
Age > 18 and < 70 years of age.
ECOG performance status 0-2.
Patients with a prior history of gastric/duodenal ulcers documented on endoscopy can be enrolled as long as the ulcers did not cause bleeding requiring a blood transfusion/major intervention.
No history of GI bleeding requiring a blood transfusion, endoscopic or operative intervention.
No history of any prior stroke (hemorrhagic or ischemic).
No concurrent anticoagulation with warfarin, heparin/heparin analogues, clopidogrel, direct thrombin inhibitors, or direct factor XA inhibitors.
No history of atrial fibrillation or myocardial infarction.
No history of grade 4 hypertension, defined as hypertension resulting in lifethreatening consequences

Parents must live together
Parents must be expecting their first baby together
We must start working with the couple before the baby is born
Parents must be 18 years or older
Families who can speak and understand English
Single-parent families
Families with more than one-child
Familes who cannot speak or understand English
Families in which one parent is under the age of 18

forestry or climate science related majors (include but not limited to agricultural sciences, environmental resources management, forest ecosystem management, plant science, ecology, biology, meteorology and atmospheric science)
undergraduate or graduate students at Penn State University who are older than 18.
participants should be healthy (without contagious disease)
people under 18
people who are cognitively impaired
people who have contagious disease

Individuals who had some experience with chronic pain over the last 6 months
Living in homes with internet access
Willing to use a smart-home device (Amazon Alexa)
Have access to a smart phone
Read, write, and speak English
Under 18 years old
Major mental health issue that is not currently under advisement of a doctor/therapist
Actively struggling with addiction to substances or newly in recovery
Participants who currently report using mindfulness practices more than 1x a month

18 years and older
Working towards a degree in a field requiring high vocal demand (e.g. future teachers, lawyers, voice performers including singers and actors)
Currently being treated for a voice disorder

Ages 21-70
Smoke 5 or more cigarettes per day
Must be willing to both switch to a different type of cigarette and try an electronic cigarette
No serious quit attempt or use of smoking cessation medication in the past 30 days
Meet diagnostic criteria for current or lifetime mental health condition
Women who are pregnant, nursing, or trying to become pregnant
Any known allergy to propylene glycol or vegetable glycerin
History of difficulty providing blood samples
Other member of the household currently participating in the study
Unstable or significant medical condition in the past 3 months

Moderate to Severe HS for at least 1 year
HS lesions in at least 2 affected areas
Willing to follow all study instructions
Certain treatments for HS are not allowed; coordinator will discuss specific treatments
unable or unwilling to return to the study site for all study visits and tests.
Known Hepatitis B, Hepatitis C, or HIV infections

At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year

moderate to severe crohn's disease, 3 months
failed prior treatment
severe or fulminant colitis requiring surgery
presence of stoma, gastric pouch
prior bowel resection, 6 months
bleeding disorders
cancer < 5 years

65 or older
no diagnosis of dementia
available for 6 months
64 or younger
dementia or motor movement disorder diagnosis
cognitive training within past 2 years

Age 25-70 years
BMI 25-40 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Not willing to consume all meals and snacks provided for the study

PN involving 2 affected areas
Willing to follow all study directions and attend appointments
PN affecting only 1 part of the body
Certain diagnosis associated with PN are not allowed, coordinator will discuss specifics

Taken at least 10 Uber/Lyft ride in the last 12 months.
You are willing to share several of your past Uber/Lyft trip records in the app with us.
You are a current or past employee with one of the ride-sharing corporations (Uber/Lyft)

age 18-80
Have high blood pressure despite taking blood pressure medicine
You have not donated a kidney
You have had removal of a kidney or kidney transplant
You have type 1 diabetes or severe type 2
Have severe untreated obstructive sleep apnea
Bleeding disorder

Age 18-25 years
Enrolled in undergraduate degree program at Penn State's University Park Campus
Access to internet between 8:00 AM and 2:00 PM
Proficient in English language
Living in University Park or State College this semester
Not between ages 18-25 years
Not enrolled in undergraduate degree program at Penn State's University Park campus
No access to internet between 8:00 AM and 2:00 PM
Not proficient in English language
Not living in University Park or State College this semester

Adults age >=18 or <70 years
Liver cancer diagnosis (HCC)
absence of all detectable cancer after your treatment
active heart problems
BMI <18 or >45 kg/m2
Severe medical or mental illness

Men and women of all races
18- 60 years old
Previously Diagnosed with POTS or healthy people without chronic illness
Capable of giving informed consent
Age <18 years or >60 years
Pregnant or breastfeeding women
Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration)
Taking stimulant medications within the past 3 months as these may alter cognition
Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal)

Diagnosed with myasthenia gravis for at least 6 months
Myasthenia Gravis Foundation of America (MGFA) classification: Class II to IV
Weigh at least 40 kg (about 88 lbs)
History of thymectomy (removal of the thymus gland) within 12 months
Active or untreated thymoma (tumor of the thymus gland)
History of meningococcal infection
HIV infection
Pregnancy

Over 18 in age
English is first language
Right-handed
No history of neurological injury or disease
Under 300 lbs in weight
Claustrophobic
Taking medication that affects brain or blood flow